肿瘤、间质和免疫系统之间的动态相互作用可以驱动或阻止肿瘤进展
Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression
摘要：
在肿瘤微环境中，癌细胞直接与免疫系统和基质相互作用。免疫系统在历史上被认为是身体防御肿瘤进展的主要部分，它可以被肿瘤细胞重新编程为无效，失活，甚至获得肿瘤促进表型。同样，基质细胞和细胞外基质也可以具有促肿瘤和抗肿瘤特性。然而，有强有力的证据表明，基质和免疫系统也直接相互作用，因此在癌细胞、免疫细胞和肿瘤基质之间产生了三方相互作用。这种相互作用有助于维持具有促肿瘤发生免疫表型的慢性炎症肿瘤微环境，并促进转移性播散。因此，需要在免疫系统和肿瘤间质的动态相互作用的背景下全面了解癌症，以真正了解恶性肿瘤的进展和过去。
英文摘要：
In the tumour microenvironment, cancer cells directly interact with both the immune system and the stroma. It is firmly established that the immune system, historically believed to be a major part of the body's defence against tumour progression, can be reprogrammed by tumour cells to be ineffective, inactivated, or even acquire tumour promoting phenotypes. Likewise, stromal cells and extracellular matrix can also have pro-and anti-tumour properties. However, there is strong evidence that the stroma and immune system also directly interact, therefore creating a tripartite interaction that exists between cancer cells, immune cells and tumour stroma. This interaction contributes to the maintenance of a chronically inflamed tumour microenvironment with pro-tumorigenic immune phenotypes and facilitated metastatic dissemination. A comprehensive understanding of cancer in the context of dynamical interactions of the immune system and the tumour stroma is therefore required to truly understand the progression toward and past malignancy.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
