信号网络细胞内运输控制的运输坐标描述
Trafficking Coordinate Description of Intracellular Transport Control of Signaling Networks
摘要：
许多细胞网络依赖于其组分的调节转运，以将细胞外信息转化为精确的细胞内信号。这些网络的动力学通常用划分的化学反应来描述。然而，在许多重要的情况下，隔室的性质以一种自然无法用化学反应描述的方式不断变化。在这里，我们开发了一种基于沿着运输坐标的运输的方法来精确描述这些过程，并将其明确应用于TGF-β信号转导网络，该网络在许多疾病和细胞过程中起着重要作用。这种新引入的方法的结果首次准确地捕获了具有和不具有癌症背景的细胞的不同TGF-β信号传导动力学，并提供了一种以密切概括观察到的细胞行为的方式预测化学扰动的影响的途径。
英文摘要：
Many cellular networks rely on the regulated transport of their components to transduce extracellular information into precise intracellular signals. The dynamics of these networks is typically described in terms of compartmentalized chemical reactions. There are many important situations, however, in which the properties of the compartments change continuously in a way that cannot naturally be described by chemical reactions. Here, we develop an approach based on transport along a trafficking coordinate to precisely describe these processes and we apply it explicitly to the TGF-β signal transduction network, which plays a fundamental role in many diseases and cellular processes. The results of this newly introduced approach accurately capture for the first time the distinct TGF-β signaling dynamics of cells with and without cancerous backgrounds and provide an avenue to predict the effects of chemical perturbations in a way that closely recapitulates the observed cellular behavior.
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