细胞内钙信号的简化模型中的多模式编码
Multimodal encoding in a simplified model of intracellular calcium signaling
摘要：
许多细胞使用钙信号将信息从质膜的细胞外侧传递到其内部的靶点。由于几乎所有的细胞都采用了一个网络的生化反应的Ca2+信号，许多努力已经致力于了解的功能作用的Ca2+反应，并破译其复杂的动力学是如何调节的生化网络的Ca2+相关的信号转导途径。实验观察表明，响应于外部刺激的Ca 2+信号通过频率调制或可选地通过幅度调制来编码信息。虽然最小模型可以单独捕获两种类型的动态，但它们未能表现出不同的和更高级的编码模式。通过分歧理论的论证，我们提出在某些生物物理条件下，更复杂的信息编码模式也可以由最小模型来表现。我们认为最小模型的Li和Rinzel和信息编码可以发生的振幅调制（AM）的Ca2+振荡，频率调制（FM）或两种模式（AFM）。我们的工作是由星形胶质细胞中的钙信号传导激发的，星形胶质细胞是皮质神经胶质细胞的主要类型，现在被认为在神经元活动和大脑信息处理的调节中起着至关重要的作用。我们解释说，我们的研究结果可以是至关重要的，更好地了解突触信息传递。此外，我们的研究结果也可能是重要的，更好地了解其他例子的生理过程调节的钙离子信号。
英文摘要：
Many cells use calcium signalling to carry information from the extracellular side of the plasma membrane to targets in their interior. Since virtually all cells employ a network of biochemical reactions for Ca2+ signalling, much effort has been devoted to understand the functional role of Ca2+ responses and to decipher how their complex dynamics is regulated by the biochemical network of Ca2+-related signal transduction pathways. Experimental observations show that Ca2+ signals in response to external stimuli encode information via frequency modulation or alternatively via amplitude modulation. Although minimal models can capture separately both types of dynamics, they fail to exhibit different and more advanced encoding modes. By arguments of bifurcation theory, we propose instead that under some biophysical conditions more complex modes of information encoding can also be manifested by minimal models. We consider the minimal model of Li and Rinzel and show that information encoding can occur by amplitude modulation (AM) of Ca2+ oscillations, by frequency modulation (FM) or by both modes (AFM). Our work is motivated by calcium signalling in astrocytes, the predominant type of cortical glial cells that is nowadays recognized to play a crucial role in the regulation of neuronal activity and information processing of the brain. We explain that our results can be crucial for a better understanding of synaptic information transfer. Furthermore, our results might also be important for better insight on other examples of physiological processes regulated by Ca2+ signalling.
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