高尔基池从头生物发生的非平衡机制
Nonequilibrium mechanisms underlying de novo biogenesis of Golgi cisternae
摘要：
细胞生物学中的一个中心问题是细胞内运输途径中细胞器生物发生的物理化学基础，其最令人印象深刻的表现是高尔基池的生物发生。在一个基本的水平上，这种形态和化学上不同的隔室应该产生于分子运输和化学成熟之间的相互作用。在这里，我们制定了易于分析的，最低限度的模型，将这种相互作用之间的物理空间的运输和化学进展，并探讨不同的池从头生源的条件。我们提出了新的定量措施，可以区分各种模型的运输在一个定性的方式-这包括措施的动态稳定状态和动态响应的扰动的那种适合活细胞成像。
英文摘要：
A central issue in cell biology is the physico-chemical basis of organelle biogenesis in intracellular trafficking pathways, its most impressive manifestation being the biogenesis of Golgi cisternae. At a basic level, such morphologically and chemically distinct compartments should arise from an interplay between the molecular transport and chemical maturation. Here, we formulate analytically tractable, minimalist models, that incorporate this interplay between transport and chemical progression in physical space, and explore the conditions for de novo biogenesis of distinct cisternae. We propose new quantitative measures that can discriminate between the various models of transport in a qualitative manner- this includes measures of the dynamics in steady state and the dynamical response to perturbations of the kind amenable to live-cell imaging.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
