运输通路中细胞内细胞器的主动形态动力学
Active morphodynamics of intracellular organelles in the trafficking pathway
AI总结：
本研究针对内膜系统细胞器形态与功能关联但形成维持物理原理不明的问题，从主动机械化学循环解析分裂融合事件，揭示其流体动力学尺度表现及与形态的耦合，阐明高尔基体样结构的自然形成机制。
摘要：
从高尔基体到内体，内膜系统中的细胞器呈现出复杂多样的形态，这些形态往往与其功能相关。由于较小运输囊泡的定向流动，这种膜结合细胞器远离平衡态；因此，控制这些结构形成和维持的物理原理仍然难以捉摸。通过从主动机械化学循环的角度理解单个分裂和融合事件，我们展示了这种运输如何在流体动力学尺度上表现出来，不仅导致物质（如膜面积和包裹体积）的流动，还产生驱动细胞器与其胞质环境之间动量传递的主动应力。由于边界膜的流体和可变形性质，这产生了新的物理学，将非平衡力与细胞器组成、形态和流体动力学流动耦合起来。我们证明了稳定的区室漂移和分枝的囊状形态（均让人联想到高尔基体潴泡）如何从分裂和融合的相同潜在非平衡动力学中自然产生。
英文摘要：
From the Golgi apparatus to endosomes, organelles in the endomembrane system exhibit complex and varied morphologies that are often related to their function. Such membrane-bound organelles operate far from equilibrium due to directed fluxes of smaller trafficking vesicles; the physical principles governing the emergence and maintenance of these structures have thus remained elusive. By understanding individual fission and fusion events in terms of active mechano-chemical cycles, we show how such trafficking manifests at the hydrodynamic scale, resulting not only in fluxes of material -- such as membrane area and encapsulated volume -- but also in active stresses that drive momentum transfer between an organelle and its cytosolic environment. Due to the fluid and deformable nature of the bounding membrane, this gives rise to novel physics, coupling nonequilibrium forces to organelle composition, morphology and hydrodynamic flows. We demonstrate how both stable compartment drift and ramified sac-like morphologies, each reminiscent of Golgi-cisternae, emerge naturally from the same underlying nonequilibrium dynamics of fission and fusion.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
