IPIP：一种直接优化剂量学指标的HDR近距离放射治疗逆向计划新方法
IPIP: A New Approach to Inverse Planning for HDR Brachytherapy by Directly Optimizing Dosimetric Indices
摘要：
目的：高剂量率（HDR）近距离放射治疗计划的许多计划方法需要迭代方法。假设一组计算参数将给出符合剂量测定标准的剂量计划。使用这些参数计算剂量计划，并且如果不满足任何剂量学标准，则迭代该过程直到找到合适的剂量计划。本研究的目的是通过开发一种新的方法来改善HDR近距离放射治疗计划，该方法根据剂量测定标准直接优化剂量分布。方法：我们开发了用于计算HDR近距离放射治疗剂量计划的优化模型和快速启发式算法--对剂量测定进行了评价，并与剂量测定标准进行了比较。结果：IPIP计算的剂量计划在单次迭代后满足靶组织和健康组织的所有给定剂量学标准。平均目标覆盖率为95%。IPIP的平均计算时间是30.1秒，在英特尔（R）CoreTM 2双核CPU 1.67 GHz处理器与3 Gib RAM。结论：IPIP是一种直接结合剂量学标准的HDR近距离放射治疗计划系统。我们已经证明，IPIP在剂量测定和运行时间方面对于本研究中使用的前列腺病例和剂量测定标准具有临床可接受的性能。需要进一步的研究来确定IPIP是否适用于更一般的患者组和剂量测定标准，包括其他癌症部位，如妇科。
英文摘要：
Purpose: Many planning methods for high dose rate (HDR) brachytherapy treatment planning require an iterative approach. A set of computational parameters are hypothesized that will give a dose plan that meets dosimetric criteria. A dose plan is computed using these parameters, and if any dosimetric criteria are not met, the process is iterated until a suitable dose plan is found. In this way, the dose distribution is controlled by abstract parameters. The purpose of this study is to improve HDR brachytherapy planning by developing a new approach that directly optimizes the dose distribution based on dosimetric criteria. Method: We develop Inverse Planning by Integer Program (IPIP), an optimization model for computing HDR brachytherapy dose plans and a fast heuristic for it. We used our heuristic to compute dose plans for 20 anonymized prostate cancer patient image data sets from our clinic database. Dosimetry was evaluated and compared to dosimetric criteria. Results: Dose plans computed from IPIP satisfied all given dosimetric criteria for the target and healthy tissue after a single iteration. The average target coverage was 95%. The average computation time for IPIP was 30.1 seconds on a Intel(R) CoreTM2 Duo CPU 1.67 GHz processor with 3 Gib RAM. Conclusion: IPIP is an HDR brachytherapy planning system that directly incorporates dosimetric criteria. We have demonstrated that IPIP has clinically acceptable performance for the prostate cases and dosimetric criteria used in this study, both in terms of dosimetry and runtime. Further study is required to determine if IPIP performs well for a more general group of patients and dosimetric criteria, including other cancer sites such as GYN.
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