AC电场中磷脂巨囊泡的频率依赖性电变形
Frequency-dependent electrodeformation of giant phospholipid vesicles in AC electric field
摘要：
描述了囊泡电变形的模型，该模型通过使膜弯曲能和由于电场引起的能量的总和最小化来获得参数化囊泡形状。囊泡膜和囊泡内外的水性介质都被视为渗漏的囊泡，囊泡本身被建模为封闭在薄膜内的近似球形。它表明：（a）该模型实现了一个很好的定量协议与实验确定的长扁过渡频率在kHz范围内，和（b）该模型可以解释的相图的形状的巨大磷脂囊泡相对于两个参数：所施加的AC电场的频率和囊泡内部和外部的水性介质的电导率的比率，在最近的一篇论文中（S。Aranda等人，Biophys. J. 95：L19-L21，2008）。磷脂囊泡的频率依赖性的形状转变的微升样品的电导法中的一个可能的用途进行了讨论。
英文摘要：
A model of vesicle electrodeformation is described which obtains a parametrized vesicle shape by minimizing the sum of the membrane bending energy and the energy due to the electric field. Both the vesicle membrane and the aqueous media inside and outside the vesicle are treated as leaky dielectrics, and the vesicle itself is modelled as a nearly spherical shape enclosed within a thin membrane. It is demonstrated (a) that the model achieves a good quantitative agreement with the experimentally determined prolate-to-oblate transition frequencies in the kHz range, and (b) that the model can explain a phase diagram of shapes of giant phospholipid vesicles with respect to two parameters: the frequency of the applied AC electric field and the ratio of the electrical conductivities of the aqueous media inside and outside the vesicle, explored in a recent paper (S. Aranda et al., Biophys. J. 95:L19--L21, 2008). A possible use of the frequency-dependent shape transitions of phospholipid vesicles in conductometry of microliter samples is discussed.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
