多层磷脂双层膜形成巨囊泡的水化过程
Hydration process of multi-stacked phospholipid bilayers to form giant vesicles
摘要：
用时间分辨小角X射线散射研究了多层磷脂双层膜形成巨囊泡的水化过程。在液晶相中的脂质的水合被发现进行在两个阶段。在早期阶段，直到水合后约100 s，固体基质上的脂质双层溶胀约12 $\rmÅ$，并达到准稳定状态。在后期，几百秒后，脂质双层逐渐从堆叠中剥离。另一方面，在凝胶相中的脂质的情况下，仅观察到早期阶段。这些行为对应于取决于脂质相的巨囊泡形成的能力。根据Kramers公式讨论了剥离过程的动力学。
英文摘要：
The hydration process of multi-stacked phospholipid bilayers to form giant vesicles was investigated by time-resolved small angle X-ray scattering. The hydration of lipids in the liquid-crystalline phase was found to proceed in two stages. In the early stage, until about 100 s after hydration, lipid bilayers on a solid substrate swell about 12 $\rmÅ$ and reach a quasi-stable state. In the late stage, after several hundreds of seconds, lipid bilayers gradually peel off from the stack. On the other hand, in the case of a lipid in the gel phase, only the early stage is observed. These behaviors correspond to the capacity for the giant vesicle formation depending on the lipid phases. The kinetics of the peeling-off process is discussed in terms of Kramers' formulas.
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