应力松弛显微镜（STREM）：成像细胞中的机械力衰减
Stress relaxation microscopy (STREM): Imaging mechanical force decay in cells
摘要：
我们已经开发了一种新的扫描探针为基础的方法来研究细胞生物力学。在恒定的局部变形的扫描探针上的细胞表面施加的力的时间依赖性已被用来提取局部弛豫响应。广义麦克斯韦粘弹性模型，占多松弛充分描述了力学行为的细胞表面表现出双峰松弛。在测试的力（0.1-4 nN）的范围内的一个缓慢和快速的松弛与特征时间为0.1和1秒已被检测到，并分配到重排的细胞膜和细胞骨架皮质，分别。弛豫时间映射允许同时检测膜和细胞骨架机械行为的不均匀性，并且可以用作细胞类型和细胞疾病的识别和诊断工具。
英文摘要：
We have developed a novel scanning probe-based methodology to study cell biomechanics. The time dependence of the force exerted by the cell surface on a scanning probe at constant local deformation has been used to extract local relaxational responses. The generalized Maxwell viscoelastic model that accounts for multi relaxations fully describes the mechanical behaviour of the cell surface that exhibits a bimodal relaxation. Within the range of tested forces (0.1-4 nN) a slow and a fast relaxation with characteristic times of 0.1 and 1s have been detected and assigned to rearrangements in the cell membrane and cytoskeleton cortex, respectively. Relaxation time mapping allows to simultaneously detect non-uniformities in membrane and cytoskeletal mechanical behaviour and can be used as both identifying and diagnosing tools for cell type and cell disease.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
