关于microRNA-mediated前馈回路的功能性质
On the functional properties of microRNA-mediated feed forward loops
摘要：
动机：最近的基因组规模的调控网络的研究表明，前馈回路（FFL）电路是许多这样的网络的关键组成部分。这导致了对不同FFL类型的功能特性的研究，其中调控元件是转录因子。结果：在这里，我们调查这些属性时，环的介导调控元件是一个microRNA。我们发现，许多的FFL属性在此设置中得到增强。然后，我们继续识别D中的所有此类FFL。黑腹菌调控网络。我们观察到，在植根于相同转录因子的FFL中，预测的转录因子和microRNA的结合位点的数量之间存在显著的相关性。结论：基于建模方法，我们认为这些相关性可能是转录因子偏好的FFL类型的结果。这可能有助于阐明TF赋予的调节类型。
英文摘要：
Motivation: Recent studies of genomic-scale regulatory networks suggested that a feed-forward loop (FFL) circuitry is a key component of many such networks. This led to a study of the functional properties of different FFL types, where the regulatory elements are transcription factors. Results: Here we investigate these properties when the mediating regulatory element of the loop is a microRNA. We find that many of the FFL properties are enhanced within this setup. We then proceed to identify all such FFLs in the D. Melanogaster regulatory network. We observe that in FFLs rooted at the same transcription factor there are significant correlations between the number of predicted binding sites for the transcription factor and for the microRNA. Conclusions: Based on a modeling approach we suggest that these correlations may be an outcome of the type of FFL preferred by the transcription factor. This may help elucidate the type of regulation the TF confers.
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