细胞中的microRNA-mediated噪声处理：战斗还是游戏？
microRNA-mediated noise processing in cells: a fight or a game?
摘要：
在过去的几十年里，microRNA（miRNA）因其参与转录后调控和相关疾病的发生而引起了生命科学和理论科学界的广泛关注。由于实验技术的不断完善，miRNA作为“噪音处理单元”的作用得到了进一步阐明，理论和实验研究的结合出现了两种主要的miRNA噪音控制方式。一方面，人们认为miRNA可以缓冲基因表达噪音，但最近有人提出，miRNA也可以增加其靶点的细胞间变异性。在这篇迷你评论中，我们专注于miRNA在噪声处理中的作用以及相关理论模型定义的参数的推断。
英文摘要：
In the past decades microRNAs (miRNA) have much attracted the attention of researchers at the interface between life and theoretical sciences for their involvement in post-transcriptional regulation and related diseases. Thanks to the always more sophisticated experimental techniques, the role of miRNAs as "noise processing units" has been further elucidated and two main ways of miRNA noise-control have emerged by combinations of theoretical and experimental studies. While on one side miRNA were thought to buffer gene expression noise, it has recently been suggested that miRNA could also increase the cell-to-cell variability of their targets. In this Mini Review, we focus on the miRNA role in noise processing and on the inference of the parameters defined by the related theoretical modelling.
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