相互作用核糖体的运输：单机机械化学对蛋白质合成的影响
Traffic of interacting ribosomes: effects of single-machine mechano-chemistry on protein synthesis
摘要：
许多核糖体同时在同一信使RNA（mRNA）上移动，每个核糖体分别合成由mRNA编码的蛋白质。早期的核糖体运输模型用一个“自推进粒子”来表示每个核糖体，并通过完全不对称简单排除过程（TASEP）的扩展来捕获动力学。相比之下，在这里，我们开发了一个理论模型，不仅包括相互作用的核糖体的相互排斥，但也明确描述了这些单独的循环机器在蛋白质合成过程中的机械化学。利用非平衡统计力学的分析和数值技术，我们分析了这个模型，并说明其权力，通过实验测试的预测蛋白质合成的速度在实时和密度分布的核糖体上的一些mRNA在大肠杆菌。
英文摘要：
Many ribosomes simultaneously move on the same messenger RNA (mRNA), each separately synthesizing the protein coded by the mRNA. Earlier models of ribosome traffic represent each ribosome by a ``self-propelled particle'' and capture the dynamics by an extension of the totally asymmetric simple exclusion process (TASEP). In contrast, here we develope a theoretical model that not only incorporates the mutual exclusions of the interacting ribosomes, but also describes explicitly the mechano-chemistry of each of these individual cyclic machines during protein synthesis. Using analytical and numerical techniques of non-equilibrium statistical mechanics, we analyze this model and illustrate its power by making experimentally testable predictions on the rate of protein synthesis in real time and the density profile of the ribosomes on some mRNAs in E-Coli.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
