微生物基因组的准复制和通用长度
Quasireplicas and universal lengths of microbial genomes
摘要：
对108个微生物全基因组中短词出现频率分布的统计分析表明，存在一组所有微生物基因组共有的通用“根序列长度”。这些长度和它们的普遍性为微生物基因组的生长方式提供了强有力的线索。我们发现，所观察到的基因组特性的基因组增长模型，其中原始基因组增长主要是由最大限度地随机复制的短片段从初始长度约200个核苷酸（nt）的长度约为100万nt的典型的微生物基因组。本研究的结果的相关性，同时随机增长和信息采集的基因组的性质，所谓的RNA世界中，生命进化之前的蛋白质和酶的崛起和其他几个主题进行了讨论。
英文摘要：
Statistical analysis of distributions of occurrence frequencies of short words in 108 microbial complete genomes reveals the existence of a set of universal "root-sequence lengths" shared by all microbial genomes. These lengths and their universality give powerful clues to the way microbial genomes are grown. We show that the observed genomic properties are explained by a model for genome growth in which primitive genomes grew mainly by maximally stochastic duplications of short segments from an initial length of about 200 nucleotides (nt) to a length of about one million nt typical of microbial genomes. The relevance of the result of this study to the nature of simultaneous random growth and information acquisition by genomes, to the so-called RNA world in which life evolved before the rise of proteins and enzymes and to several other topics are discussed.
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