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arXiv 0704.2114physics.gen-phphysics.bio-ph
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红鳍东方鲀基因组中DNA碱基CG频率分布的普适谱

Universal spectrum for DNA base CG frequency distribution in Takifugu rubripes (Puffer fish) genome

A. M. Selvam

摘要:

DNA碱基A、C、G、T的频率分布具有分形涨落,这在自然界动力学系统中是普遍存在的。分形涨落的功率谱表现出逆幂律形式,表明局部(小尺度)和全局(大尺度)扰动之间存在长程相关。作者在经典统计物理的基础上发展了分形涨落的一般系统理论,它预言了涡旋振幅的概率分布和分形涨落的方差(涡旋振幅的平方)谱遵循以黄金平均值为函数的普适玻尔兹曼逆幂律。模型预测的分布非常接近统计正态分布,波动范围在平均值的两个标准差内,并显示出一个胖长尾。本文证明了红鳍东方鲀基因组Release 4中DNA碱基CG频率分布呈现出与模型预测一致的普适逆幂律形式。观察到的DNA碱基的远程相关性意味着似乎是多余的非编码“垃圾”或“自私”DNA也可能有助于蛋白质编码DNA的有效功能,这一结果得到了最近研究的支持。

英文摘要:

The frequency distribution of DNA bases A, C, G, T exhibit fractal fluctuations ubiquitous to dynamical systems in nature. The power spectra of fractal fluctuations exhibit inverse power law form signifying long-range correlations between local (small-scale) and global (large-scale) perturbations. The author has developed a general systems theory based on classical statistical physics for fractal fluctuations which predicts that the probability distribution of eddy amplitudes and the variance (square of eddy amplitude)spectrum of fractal fluctuations follow the universal Boltzmann inverse power law expressed as a function of the golden mean. The model predicted distribution is very close to statistical normal distribution for fluctuations within two standard deviations from the mean and exhibits a fat long tail. In this paper it is shown that DNA base CG frequency distribution in Takifugu rubripes (Puffer fish) Genome Release 4 exhibit universal inverse power law form consistent with model prediction. The observed long-range correlations in the DNA bases implies that the non-coding 'junk' or 'selfish' DNA which appear to be redundant, may also contribute to the efficient functioning of the protein coding DNA, a result supported by recent studies.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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