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arXiv 2606.31997cond-mat.stat-mechphysics.bio-ph
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Hi-C 图谱中的多重分形标度

Multifractal Scaling in Hi-C Maps

Umeå University(于默奥大学);Sungkyunkwan University(成均馆大学);University of Vienna(维也纳大学)

Seong-Gyu Yang, Lucas Hedström, Jan Smrek, Ludvig Lizana

AI总结:

本文证明 Hi-C 图谱的多重分形结构直接源于幂律接触概率 P(s),并解析推导了质量指数 τ(q),揭示了其与聚合物接触统计的普适联系。

摘要:

染色体的三维组织展现出丰富的尺度依赖结构,这一点已通过染色体接触图谱(如 Hi-C 图谱)和显微镜测量的染色质密度所揭示。近期研究在这些数据中报告了多重分形标度。然而,这种标度行为的起源仍不清楚:现有工作通过假设模型对其进行描述。这里,我们表明 Hi-C 图谱的多重分形结构是幂律接触概率 $P(s)$ 的直接结果,而 $P(s)$ 本身是从 Hi-C 图谱中测量的经验可观测量。从具有单一指数 $\gamma$ 的 $P(s)$ 出发,我们解析推导了质量指数 $\tau(q)$,它表征了接触密度的 $q$ 阶矩如何随用于粗粒化基因组坐标的盒子大小 $l$ 标度。这种多重分形行为反映了片段内和片段间接触的几何竞争。我们发现,当 $\gamma < 1$ 时,$\tau(q)$ 在大 $q$ 处的斜率为 $2 - \gamma$;当 $\gamma \geq 1$ 时,斜率为 $1$。我们进一步表明,这种行为对噪声具有鲁棒性,并在不同生物体中一致,表明它是染色质组织的普遍特征。我们将分析扩展到双指数 $P(s)$,并展示了多重分形行为中的 $l$ 依赖性。综合这些结果,我们为多重分形标度提供了物理解释,并建立了 Hi-C 图谱中的多重分形性与聚合物接触统计之间的直接联系,其中 $\tau(q)$ 在大 $q$ 处的斜率映射到已知的聚合物接触指数。

英文摘要:

The three-dimensional organization of the genome exhibits rich, scale-dependent structure, as revealed by both chromosome contact maps (e.g., Hi-C maps) and chromatin density measured by microscopy. Recent studies have reported multifractal scaling in these data. Yet, the origin of this scaling behavior remains unclear: existing efforts describe it through postulated models. Here, we show that the multifractal structure of Hi-C maps is a direct consequence of the power-law contact probability $P(s)$, which is itself an empirical observable measured from Hi-C maps. Starting from $P(s)$ with a single exponent $γ$, we analytically derive the mass exponent $τ(q)$, which characterizes how the $q$-th moment of contact density scales with box size $l$ used to coarse-grain the genomic coordinate. This multifractal behavior reflects the geometric competition between intra- and inter-segment contacts. We find that the slope of $τ(q)$ at large $q$ is given by $2 -γ$ when $γ<1$, and by $1$ when $γ\geq 1$. We further show that this behavior is robust to noise and consistent across diverse organisms, indicating that it is a universal feature of chromatin organization. We extend our analysis into double-exponent $P(s)$, and show the $l$ dependence in multifractal behavior. Taken together, these results provide a physical explanation for multifractal scaling and establish a direct link between the multifractality in Hi-C maps and polymer contact statistics, with the large-$q$ slope of $τ(q)$ mapping onto a known polymer contact exponent.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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