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基于扩散增强的任务引导时空网络用于基于EEG的痴呆症诊断和MMSE预测

Task-guided Spatiotemporal Network with Diffusion Augmentation for EEG-based Dementia Diagnosis and MMSE Prediction

Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University(湖南生物信息省重点实验室,计算机科学与工程学院,中南大学);Xinjiang Engineering Research Center of Big Data and Intelligent Software, School of Software, Xinjiang University(新疆大数据与智能软件工程研究中心,软件学院,新疆大学);School of Science and Engineering, University of Dundee(科学与工程学院,邓迪大学);Department of Neurology, Xiangya Hospital, Central South University(神经内科,湘雅医院,中南大学)

Xiaoyu Zheng, Xu Tian, Bin Jiao, Kunbo Cui, Hanhe Lin, Lu Shen, Jin Liu

AI总结:

本文提出任务引导时空网络,通过多频段特征融合模块和扩散增强模块,提升EEG数据中痴呆症诊断和MMSE预测的准确性与鲁棒性。

摘要:

痴呆症患者通常表现出认知障碍,这通常通过迷你心理状态检查(MMSE)进行评估。同时,其潜在的神经生理异常反映在脑电图(EEG)中,为联合建模提供了基础。然而,传统多任务方法面临特征纠缠问题,导致在处理异构目标时产生任务干扰。为解决这一挑战,我们提出了一种任务引导时空网络(TGSN)和扩散增强模块,用于EEG基于的痴呆症诊断和MMSE预测。具体而言,TGSN集成了多频段特征融合模块,以捕捉EEG中的互补频谱信息。同时,引入了使用扩散过程的预训练数据增强模块,以增加样本多样性。为了建模EEG的复杂时空模式,我们提出了一个门控时空注意力模块,以捕捉长距离空间依赖性和时间动态。此外,我们设计了一个任务引导查询模块,以实现任务特定的特征提取,从而减轻任务干扰。TGSN在XY02数据集上进行了有效性评估。实验结果表明,所提出的网络优于几种最先进的方法,实现了阿尔茨海默病(AD)/前额叶痴呆(FTD)的分类准确率为97.78%,以及AD/FTD/血管性认知障碍(VCI)的分类准确率为83.93%,分别超过了最佳基线16.39%和8.28%。同时,它将MMSE预测的RMSE降低到1.93和2.38,分别比最佳基线减少了1.44和1.43。此外,对DS004504数据集的验证表明具有强大的跨数据集泛化能力...

英文摘要:

Patients with dementia typically exhibit cognitive impairment, which is routinely assessed using the Mini-Mental State Examination (MMSE). Concurrently, their underlying neurophysiological abnormalities are reflected in Electroencephalography (EEG), providing a basis for joint modeling. However, traditional multi-task approaches suffer from feature entanglement, which leads to inter-task interference when handling heterogeneous objectives.To address this challenge, we propose a task-guided spatiotemporal network (TGSN) with diffusion augmentation for EEG-based dementia diagnosis and MMSE prediction. Specifically, TGSN integrates a multi-band feature fusion module to capture complementary spectral information from EEG. Meanwhile, a pre-trained data augmentation module utilizing a diffusion process is introduced toincrease sample diversity. To model the complex spatiotemporal patterns of EEG, we propose a gated spatiotemporal attention module that captures long-range spatial dependencies and temporal dynamics. Moreover, we design a task-guided query module to achieve task-specific feature extraction, thereby mitigating task interference. The effectiveness of TGSN is evaluated on the XY02 dataset. Experimental results demonstrate that the proposed network outperforms several state-of-the-art methods, achieving classification accuracies of 97.78\% for Alzheimer's Disease (AD)/Frontotemporal Dementia (FTD) and 83.93\% for AD/FTD/Vascular Cognitive Impairment (VCI), which exceed the best baselines by 16.39\% and 8.28\%, respectively. In parallel, it reduces the RMSE for MMSE prediction to 1.93 and 2.38, achieving significant error reductions of 1.44 and 1.43 compared to the best baselines. Additionally, validation on the DS004504 dataset demonstrates strong cross-dataset generalization...

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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