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arXiv 2510.03336cs.SDcs.AIcs.LG
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基于语言和音频嵌入的阿尔茨海默病痴呆与轻度认知障碍检测机器学习方法:来自PROCESS挑战赛的洞见

Linguistic and Audio Embedding-Based Machine Learning for Alzheimer's Dementia and Mild Cognitive Impairment Detection: Insights from the PROCESS Challenge

Singapore University of Technology and Design(新加坡科技设计大学);Hochschule für Musik Detmold(音乐学院Detmold)
Adharsha Sam Edwin Sam Devahi, Sohail Singh Sangha, Prachee Priyadarshinee, Jithin Thilakan, Ivan Fu Xing Tan, Christopher Johann Clarke, Sou Ka Lon, Balamurali… 展开作者

Adharsha Sam Edwin Sam Devahi, Sohail Singh Sangha, Prachee Priyadarshinee, Jithin Thilakan, Ivan Fu Xing Tan, Christopher Johann Clarke, Sou Ka Lon, Balamurali B T, Yow Wei Quin, Chen Jer-Ming

AI总结:

本研究针对AD和MCI早期检测的侵入性问题,提出融合语音音频嵌入与语言特征的机器学习框架,在PROCESS挑战赛回归任务中表现优异,验证了多模态语音方法用于非侵入性认知评估的潜力。

摘要:

阿尔茨海默病痴呆(AD)和轻度认知障碍(MCI)的早期检测对于及时干预至关重要,但当前的诊断方法仍然资源消耗大且具有侵入性。兼具声学和语言维度的语音为认知衰退提供了一种有前景的非侵入性生物标志物。本研究中,我们为PROCESS挑战赛提出了一种机器学习框架,该框架利用从自发言语录音中提取的音频嵌入和语言特征。我们使用Whisper嵌入从“偷饼干”(Cookie Theft)描述任务中提取音频表征,而语言特征——涵盖代词使用、句法复杂度、填充词和从句结构——则从语义流畅性、音位流畅性和“偷饼干”图片描述任务的转录文本中获取。分类模型旨在区分健康对照(HC)、MCI和AD参与者,回归模型则预测简易精神状态检查(MMSE)分数。结果表明,基于拼接语言特征训练的投票集成模型取得了最佳分类性能(F1=0.497),而基于Whisper嵌入的集成回归器实现了最低的MMSE预测误差(RMSE=2.843)。在PROCESS挑战赛内的对比评估中,我们的模型在回归任务中位列顶级提交成果,在分类任务中处于中等水平,凸显了语言和音频嵌入的互补优势。这些发现强化了基于多模态语音的方法用于可扩展、非侵入性认知评估的潜力,并强调了在痴呆检测中整合任务特异性语言和声学标志物的重要性。

英文摘要:

Early detection of Alzheimer's Dementia (AD) and Mild Cognitive Impairment (MCI) is critical for timely intervention, yet current diagnostic approaches remain resource-intensive and invasive. Speech, encompassing both acoustic and linguistic dimensions, offers a promising non-invasive biomarker for cognitive decline. In this study, we present a machine learning framework for the PROCESS Challenge, leveraging both audio embeddings and linguistic features derived from spontaneous speech recordings. Audio representations were extracted using Whisper embeddings from the Cookie Theft description task, while linguistic features-spanning pronoun usage, syntactic complexity, filler words, and clause structure-were obtained from transcriptions across Semantic Fluency, Phonemic Fluency, and Cookie Theft picture description. Classification models aimed to distinguish between Healthy Controls (HC), MCI, and AD participants, while regression models predicted Mini-Mental State Examination (MMSE) scores. Results demonstrated that voted ensemble models trained on concatenated linguistic features achieved the best classification performance (F1 = 0.497), while Whisper embedding-based ensemble regressors yielded the lowest MMSE prediction error (RMSE = 2.843). Comparative evaluation within the PROCESS Challenge placed our models among the top submissions in regression task, and mid-range for classification, highlighting the complementary strengths of linguistic and audio embeddings. These findings reinforce the potential of multimodal speech-based approaches for scalable, non-invasive cognitive assessment and underline the importance of integrating task-specific linguistic and acoustic markers in dementia detection.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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