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arXiv 2603.19331cs.LGstat.ML
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FalconBC:用于潜伏条件生理边界条件的近似推断流匹配

FalconBC: Flow matching for Amortized inference of Latent-CONditioned physiologic Boundary Conditions

Department of Mechanical Engineering, Stanford University(斯坦福大学机械工程系);Institute for Computational and Mathematical Engineering, Stanford University(斯坦福大学计算与数学工程研究所);Bioengineering, Stanford University(斯坦福大学生物工程系);Pediatric Cardiology, Stanford University(斯坦福大学儿科心脏病学);Department of Applied and Computational Mathematics and Statistics, University of Notre Dame(诺丁汉大学应用与计算数学与统计学系)

Chloe H. Choi, Alison L. Marsden, Daniele E. Schiavazzi

AI总结:

本文提出FalconBC框架,通过概率流方法实现对患者特定生理边界条件的近似推断,解决了开放环路模型和血管病变解剖结构中边界条件无法孤立调节的问题。

摘要:

边界条件调节是患者特异性心血管建模中的关键步骤。尽管离线训练成本增加,数据驱动的变分推断最近方法能够高效估计边界条件的联合后验分布,并通过临床目标的训练努力进行近似。然而,即使是最现代的方法在两个重要场景中也存在不足:开放环路模型中已知的平均流量和假设波形形状,以及受血管病变影响的解剖结构,其中分割影响压力或流量分割目标的可达性。在两种情况下,边界条件无法孤立调节。我们介绍了一个基于概率流的通用近似推断框架,将临床目标、流入特征和患者特定解剖结构的点云嵌入视为条件变量或需要联合估计的量。我们在两个患者特定模型上展示了该方法:一个具有变化狭窄位置和严重程度的腹主动脉-髂动脉分叉,以及一个冠状动脉树。

英文摘要:

Boundary condition tuning is a fundamental step in patient-specific cardiovascular modeling. Despite an increase in offline training cost, recent methods in data-driven variational inference can efficiently estimate the joint posterior distribution of boundary conditions, with amortization of training efforts over clinical targets. However, even the most modern approaches fall short in two important scenarios: open-loop models with known mean flow and assumed waveform shapes, and anatomies affected by vascular lesions where segmentation influences the reachability of pressure or flow split targets. In both cases, boundary conditions cannot be tuned in isolation. We introduce a general amortized inference framework based on probabilistic flow that treats clinical targets, inflow features, and point cloud embeddings of patient-specific anatomies as either conditioning variables or quantities to be jointly estimated. We demonstrate the approach on two patient-specific models: an aorto-iliac bifurcation with varying stenosis locations and severity, and a coronary arterial tree.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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