Breathing rate (BR), minute ventilation (VE), and other respiratory parameters are essential for real-time patient monitoring in many acute health conditions, such as asthma. The clinical standard for measuring respiration, namely Spirometry, is hardly suitable for continuous use. Wearables can track many physiological signals, like ECG and motion, yet not respiration. Deriving respiration from other modalities has become an area of active research. In this work, we infer respiratory parameters from wearable ECG and wrist motion signals. We propose a modular and generalizable classification-regression pipeline to utilize available context information, such as physical activity, in learning context-conditioned inference models. Morphological and power domain novel features from the wearable ECG are extracted to use with these models. Exploratory feature selection methods are incorporated in this pipeline to discover application-specific interpretable biomarkers. Using data from 15 subjects, we evaluate two implementations of the proposed pipeline: for inferring BR and VE. Each implementation compares generalized linear model, random forest, support vector machine, Gaussian process regression, and neighborhood component analysis as contextual regression models. Permutation, regularization, and relevance determination methods are used to rank the ECG features to identify robust ECG biomarkers across models and activities. This work demonstrates the potential of wearable sensors not only in continuous monitoring, but also in designing biomarker-driven preventive measures.
North South University（北南大学）；Qatar University（卡塔尔大学）
Respiratory ailments such as asthma, chronic obstructive pulmonary disease (COPD), pneumonia, and lung cancer are life-threatening. Respiration rate (RR) is a vital indicator of the wellness of a patient. Continuous monitoring of RR can provide early indication and thereby save lives. However, a real-time continuous RR monitoring facility is only available at the intensive care unit (ICU) due to the size and cost of the equipment. Recent researches have proposed Photoplethysmogram (PPG) and/ Electrocardiogram (ECG) signals for RR estimation however, the usage of ECG is limited due to the unava…
With the development of wearable technologies, a new kind of healthcare data has become valuable as medical information. These data provide meaningful information regarding an individual's physiological and psychological states, such as activity level, mood, stress, and cognitive health. These biomarkers are named digital since they are collected from digital devices integrated with various sensors. In this study, we explore digital biomarkers related to stress modality by examining data collected from mobile phones and smartwatches. We utilize machine learning techniques on the Tesserae datas…
A photoplethysmography (PPG) is an uncomplicated and inexpensive optical technique widely used in the healthcare domain to extract valuable health-related information, e.g., heart rate variability, blood pressure, and respiration rate. PPG signals can easily be collected continuously and remotely using portable wearable devices. However, these measuring devices are vulnerable to motion artifacts caused by daily life activities. The most common ways to eliminate motion artifacts use extra accelerometer sensors, which suffer from two limitations: i) high power consumption and ii) the need to int…
In this paper, we present a wireless ECG-derived Respiration Rate (RR) estimation using an autoencoder with a DCT Layer. The wireless wearable system records the ECG data of the subject and the respiration rate is determined from the variations in the baseline level of the ECG data. A straightforward Fourier analysis of the ECG data obtained using the wireless wearable system may lead to incorrect results due to uneven breathing. To improve the estimation precision, we propose a neural network that uses a novel Discrete Cosine Transform (DCT) layer to denoise and decorrelates the data. The DCT…
A low-power wearable wireless sensor measuring both molecular biomarkers and physiological signals is proposed, where the former are measured by a microfluidic biosensing system while the latter are measured electrically. The low-power consumption of the sensor is achieved by an all-analog circuit implementing Analog Joint Source-Channel Coding (AJSCC) compression. The sensor is applicable to a wide range of biomedical applications that require real-time concurrent molecular biomarker and physiological signal monitoring.
Massachusetts General Hospital（麻省总医院）；University of Zurich（苏黎世大学）；Washington University School of Medicine in St. Louis（圣路易斯华盛顿大学医学院）；MyAir Inc（MyAir公司）；Beth Israel Deaconess Medical Center（贝斯以色列女执事医疗中心）
Objective: Sleep related respiratory abnormalities are typically detected using polysomnography. There is a need in general medicine and critical care for a more convenient method to automatically detect sleep apnea from a simple, easy-to-wear device. The objective is to automatically detect abnormal respiration and estimate the Apnea-Hypopnea-Index (AHI) with a wearable respiratory device, compared to an SpO2 signal or polysomnography using a large (n = 412) dataset serving as ground truth. Methods: Simultaneously recorded polysomnographic (PSG) and wearable respiratory effort data were used …
Beijing University of Posts and Telecommunications（北京邮电大学）
As elderly population grows, social and health care begin to face validation challenges, in-home monitoring is becoming a focus for professionals in the field. Governments urgently need to improve the quality of healthcare services at lower costs while ensuring the comfort and independence of the elderly. This work presents an in-home monitoring approach based on off-the-shelf WiFi, which is low-costs, non-wearable and makes all-round daily healthcare information available to caregivers. The proposed approach can capture fine-grained human pose figures even through a wall and track detailed re…
Healthcare Technology and Innovation Center (HTIC)（医疗技术与创新中心）；Indian Institute of Technology (IITM)（印度理工学院）；Department of Electrical Engineering, Indian Institute of Technology, Madras (IITM)（印度理工学院马德拉斯分校电气工程系）
The exponential rise in wearable sensors has garnered significant interest in assessing the physiological parameters during day-to-day activities. Respiration rate is one of the vital parameters used in the performance assessment of lifestyle activities. However, obtrusive setup for measurement, motion artifacts, and other noises complicate the process. This paper presents a multitasking architecture based on Deep Learning (DL) for estimating instantaneous and average respiration rate from ECG and accelerometer signals, such that it performs efficiently under daily living activities like cycli…
Swiss Federal Institute of Technology Lausanne (EPFL)（洛桑联邦理工学院）
A person's passage of time perception (POTP) is strongly linked to their mental state and stress response, and can therefore provide an easily quantifiable means of continuous mental health monitoring. In this work, we develop a custom experiment and Machine Learning (ML) models for predicting POTP from biomarkers acquired from wearable biosensors. We first confirm that individuals experience time passing slower than usual during fear or sadness (p = 0.046) and faster than usual during cognitive tasks (p = 2 x 10^-5). Then, we group together the experimental segments associated with fast, slow…
Healthcare Technology Innovation Centre (HTIC), IITM（医疗技术创新中心（HTIC），印度理工学院马德拉斯分校）；Indian Institute of Technology Madras (IITM)（印度理工学院马德拉斯分校）
Respiratory ailments afflict a wide range of people and manifests itself through conditions like asthma and sleep apnea. Continuous monitoring of chronic respiratory ailments is seldom used outside the intensive care ward due to the large size and cost of the monitoring system. While Electrocardiogram (ECG) based respiration extraction is a validated approach, its adoption is limited by access to a suitable continuous ECG monitor. Recently, due to the widespread adoption of wearable smartwatches with in-built Photoplethysmogram (PPG) sensor, it is being considered as a viable candidate for con…
Nanyang Technological University（南洋理工大学）；China-Singapore International Joint Research Institute（中新国际联合研究院）
Crucial for healthcare and biomedical applications, respiration monitoring often employs wearable sensors in practice, causing inconvenience due to their direct contact with human bodies. Therefore, researchers have been constantly searching for contact-free alternatives. Nonetheless, existing contact-free designs mostly require human subjects to remain static, largely confining their adoptions in everyday environments where body movements are inevitable. Fortunately, radio-frequency (RF) enabled contact-free sensing, though suffering motion interference inseparable by conventional filtering, …
University of California Irvine（加州大学欧文分校）；University of California, Irvine（加州大学欧文分校）；Institute for Future Health, University of California, Irvine（加州大学欧文分校未来健康研究所）
Respiratory rate (RR) is a clinical sign representing ventilation. An abnormal change in RR is often the first sign of health deterioration as the body attempts to maintain oxygen delivery to its tissues. There has been a growing interest in remotely monitoring of RR in everyday settings which has made photoplethysmography (PPG) monitoring wearable devices an attractive choice. PPG signals are useful sources for RR extraction due to the presence of respiration-induced modulations in them. The existing PPG-based RR estimation methods mainly rely on hand-crafted rules and manual parameters tunin…
Khulna University of Engineering & Technology（库尔纳工程技术大学）；Islamic University of Technology（伊斯兰技术大学）；University of Toronto（多伦多大学）
Rest is essential for a high-level physiological and psychological performance. It is also necessary for the muscles to repair, rebuild, and strengthen. There is a significant correlation between the quality of rest and the resting posture. Therefore, identification of the resting position is of paramount importance to maintain a healthy life. Resting postures can be classified into four basic categories: Lying on the back (supine), facing of the left / right sides and free-fall position. The later position is already considered to be an unhealthy posture by researchers equivocally and hence c…
Pig vital sign monitoring (e.g., estimating the heart rate (HR) and respiratory rate (RR)) is essential to understand the stress level of the sow and detect the onset of parturition. It helps to maximize peri-natal survival and improve animal well-being in swine production. The existing approach mainly relies on manual measurement, which is labor-intensive and only provides a few points of information. Other sensing modalities such as wearables and cameras are developed to enable more continuous measurement, but are still limited due to animal discomfort, data transfer, and storage challenges.…
The advent of IoT has enabled the design of connected and integrated smart health monitoring systems. These smart health monitoring systems could be realized in a smart home context to render long-term care to the elderly population. In this paper, we present the design of a wearable health monitoring system suitable for older adults in a smart home context. The proposed system offers solutions to monitor the stress, blood pressure, and location of an individual within a smart home environment. The stress detection model proposed in this work uses Electrodermal Activity (EDA), Photoplethysmogr…
A Vector-Quantized Foundation Model for Patient Behavior Monitoring
Signal Theory and Communications Department University Carlos III of Madrid（信号理论与通讯系卡洛斯三世大学）；Instituto de Investigación Sanitaria Gregorio Marañón（Gregorio Marañón卫生研究院）；Center for Data Science New York University（数据科学中心纽约大学）；Evidence-Based Behavior（基于证据的行为）；CIBERSAM, ISCIII
Electrocardiography (ECG), an electrical measurement which captures cardiac activities, is the gold standard for diagnosing cardiovascular disease (CVD). However, ECG is infeasible for continuous cardiac monitoring due to its requirement for user participation. By contrast, photoplethysmography (PPG) provides easy-to-collect data, but its limited accuracy constrains its clinical usage. To combine the advantages of both signals, recent studies incorporate various deep learning techniques for the reconstruction of PPG signals to ECG; however, the lack of contextual information as well as the lim…
Smartwatch Photoplethysmography-Derived Heart Age via ECG-Guided Cross-Modal Pretraining as a Digital Biomarker of Vascular Aging
National Institute of Health Data Science, Peking University（北京大学健康医疗大数据科学国家研究院）；Institute of Medical Technology, Peking University Health Science Center（北京大学医学部医药技术学院）；OPPO Health Lab（OPPO健康实验室）；School of Intelligence Science and Technology, Peking University（北京大学智能科学学院）；Xidian University（西安电子科技大学）；Shenzhen Technology University（深圳职业技术大学）
National Institute of Health Data Science, Peking University（北京大学健康数据科学国家研究院）；Department of Cardiology, Peking University People’s Hospital（北京大学人民医院心内科）；Institute of Medical Technology, Peking University Health Science Center（北京大学医学部医学技术学院）；Tianjin Key Laboratory of lonic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University（天津医科大学第二医院心脏研究所心内科离子-分子心血管功能天津市重点实验室）
