EVA: Generating Longitudinal Electronic Health Records Using Conditional Variational Autoencoders
Georgia Institute of Technology（佐治亚理工学院）；IBM Research（IBM研究院）；Vanderbilt University（范德堡大学）；Sutter Health（萨特健康）；University of Illinois Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）
Siddharth Biswal, Soumya Ghosh, Jon Duke, Bradley Malin, Walter Stewart, Jimeng Sun
Researchers require timely access to real-world longitudinal electronic health records (EHR) to develop, test, validate, and implement machine learning solutions that improve the quality and efficiency of healthcare. In contrast, health systems value deeply patient privacy and data security. De-identified EHRs do not adequately address the needs of health systems, as de-identified data are susceptible to re-identification and its volume is also limited. Synthetic EHRs offer a potential solution. In this paper, we propose EHR Variational Autoencoder (EVA) for synthesizing sequences of discrete EHR encounters (e.g., clinical visits) and encounter features (e.g., diagnoses, medications, procedures). We illustrate that EVA can produce realistic EHR sequences, account for individual differences among patients, and can be conditioned on specific disease conditions, thus enabling disease-specific studies. We design efficient, accurate inference algorithms by combining stochastic gradient Markov Chain Monte Carlo with amortized variational inference. We assess the utility of the methods on large real-world EHR repositories containing over 250, 000 patients. Our experiments, which include user studies with knowledgeable clinicians, indicate the generated EHR sequences are realistic. We confirmed the performance of predictive models trained on the synthetic data are similar with those trained on real EHRs. Additionally, our findings indicate that augmenting real data with synthetic EHRs results in the best predictive performance - improving the best baseline by as much as 8% in top-20 recall.
This paper demonstrates that a simple modification of the variational autoencoder (VAE) formalism enables the method to identify and classify rotated and distorted digits. In particular, the conventional objective (cost) function employed during the training process of a VAE both quantifies the agreement between the input and output data records and ensures that the latent space representation of the input data record is statistically generated with an appropriate mean and standard deviation. After training, simulated data realizations are generated by decoding appropriate latent space points.…
Synthetic data generation is increasingly important due to privacy concerns. While Autoencoder-based approaches have been widely used for this purpose, sampling from their latent spaces can be challenging. Mixture models are currently the most efficient way to sample from these spaces. In this work, we propose a new approach that models the latent space of an Autoencoder as a simplex, allowing for a novel heuristic for determining the number of components in the mixture model. This heuristic is independent of the number of classes and produces comparable results. We also introduce a sampling m…
Medical data sets are usually corrupted by noise and missing data. These missing patterns are commonly assumed to be completely random, but in medical scenarios, the reality is that these patterns occur in bursts due to sensors that are off for some time or data collected in a misaligned uneven fashion, among other causes. This paper proposes to model medical data records with heterogeneous data types and bursty missing data using sequential variational autoencoders (VAEs). In particular, we propose a new methodology, the Shi-VAE, which extends the capabilities of VAEs to sequential streams of…
Northeastern University（东北大学）；Mitsubishi Electric Research Laboratories（三菱电机研究实验室）
We introduce adversarial neural networks for representation learning as a novel approach to transfer learning in brain-computer interfaces (BCIs). The proposed approach aims to learn subject-invariant representations by simultaneously training a conditional variational autoencoder (cVAE) and an adversarial network. We use shallow convolutional architectures to realize the cVAE, and the learned encoder is transferred to extract subject-invariant features from unseen BCI users' data for decoding. We demonstrate a proof-of-concept of our approach based on analyses of electroencephalographic (EEG)…
Imperial College London（帝国理工学院）；Bogazici University（海峡大学）
We present the development of a semi-supervised regression method using variational autoencoders (VAE), which is customized for use in soft sensing applications. We motivate the use of semi-supervised learning considering the fact that process quality variables are not collected at the same frequency as other process variables leading to many unlabelled records in operational datasets. These unlabelled records are not possible to use for training quality variable predictions based on supervised learning methods. Use of VAEs for unsupervised learning is well established and recently they were u…
Recently, variational autoencoders have been successfully used to learn a probabilistic prior over speech signals, which is then used to perform speech enhancement. However, variational autoencoders are trained on clean speech only, which results in a limited ability of extracting the speech signal from noisy speech compared to supervised approaches. In this paper, we propose to guide the variational autoencoder with a supervised classifier separately trained on noisy speech. The estimated label is a high-level categorical variable describing the speech signal (e.g. speech activity) allowing f…
In order to process efficiently ever-higher dimensional data such as images, sentences, or audio recordings, one needs to find a proper way to reduce the dimensionality of such data. In this regard, SVD-based methods including PCA and Isomap have been extensively used. Recently, a neural network alternative called autoencoder has been proposed and is often preferred for its higher flexibility. This work aims to show that PCA is still a relevant technique for dimensionality reduction in the context of classification. To this purpose, we evaluated the performance of PCA compared to Isomap, a dee…
The electroencephalogram (EEG) is a powerful method to understand how the brain processes speech. Linear models have recently been replaced for this purpose with deep neural networks and yield promising results. In related EEG classification fields, it is shown that explicitly modeling subject-invariant features improves generalization of models across subjects and benefits classification accuracy. In this work, we adapt factorized hierarchical variational autoencoders to exploit parallel EEG recordings of the same stimuli. We model EEG into two disentangled latent spaces. Subject accuracy rea…
Dr. Ing. h.c. F. Porsche AG（保时捷股份公司）；Ludwig Maximilian University（路德维希-马克西米利安大学）；University of Tübingen（蒂宾根大学）；Chemnitz University of Technology（开姆尼茨工业大学）；Silicon Austria Labs（奥地利硅谷实验室）
There is a growing need for sparse representational formats of human affective states that can be utilized in scenarios with limited computational memory resources. We explore whether representing neural data, in response to emotional stimuli, in a latent vector space can serve to both predict emotional states as well as generate synthetic EEG data that are participant- and/or emotion-specific. We propose a conditional variational autoencoder based framework, EEG2Vec, to learn generative-discriminative representations from EEG data. Experimental results on affective EEG recording datasets demo…
Artificial Intelligence in healthcare is a new and exciting frontier and the possibilities are endless. With deep learning approaches beating human performances in many areas, the logical next step is to attempt their application in the health space. For these and other Machine Learning approaches to produce good results and have their potential realized, the need for, and importance of, large amounts of accurate data is second to none. This is a challenge faced by many industries and more so in the healthcare space. We present an approach of using Variational Autoencoders (VAE's) as an approa…
University of Edinburgh（爱丁堡大学）；MIT–IBM Watson AI Lab（麻省理工-IBM沃森人工智能实验室）；University of Oslo（奥斯陆大学）
Determining the positions of neurons in an extracellular recording is useful for investigating functional properties of the underlying neural circuitry. In this work, we present a Bayesian modelling approach for localizing the source of individual spikes on high-density, microelectrode arrays. To allow for scalable inference, we implement our model as a variational autoencoder and perform amortized variational inference. We evaluate our method on both biophysically realistic simulated and real extracellular datasets, demonstrating that it is more accurate than and can improve spike sorting per…
We propose a training and evaluation approach for autoencoder Generative Adversarial Networks (GANs), specifically the Boundary Equilibrium Generative Adversarial Network (BEGAN), based on methods from the image quality assessment literature. Our approach explores a multidimensional evaluation criterion that utilizes three distance functions: an $l_1$ score, the Gradient Magnitude Similarity Mean (GMSM) score, and a chrominance score. We show that each of the different distance functions captures a slightly different set of properties in image space and, consequently, requires its own evaluati…
University of Cambridge（剑桥大学）；Disney Research（迪士尼研究院）
We present a VAE architecture for encoding and generating high dimensional sequential data, such as video or audio. Our deep generative model learns a latent representation of the data which is split into a static and dynamic part, allowing us to approximately disentangle latent time-dependent features (dynamics) from features which are preserved over time (content). This architecture gives us partial control over generating content and dynamics by conditioning on either one of these sets of features. In our experiments on artificially generated cartoon video clips and voice recordings, we sho…
University of Illinois at Chicago（伊利诺伊大学芝加哥分校）；Salesforce（赛富时）
Aiming at exploiting the rich information in user behaviour sequences, sequential recommendation has been widely adopted in real-world recommender systems. However, current methods suffer from the following issues: 1) sparsity of user-item interactions, 2) uncertainty of sequential records, 3) long-tail items. In this paper, we propose to incorporate contrastive learning into the framework of Variational AutoEncoders to address these challenges simultaneously. Firstly, we introduce ContrastELBO, a novel training objective that extends the conventional single-view ELBO to two-view case and theo…
Beijing University of Posts and Telecommunications（北京邮电大学）；Duke University（杜克大学）；Stanford University（斯坦福大学）；Weill Cornell Medical College（威尔康奈尔医学院）
Probabilistic generative models are attractive for scientific modeling because their inferred parameters can be used to generate hypotheses and design experiments. This requires that the learned model provide an accurate representation of the input data and yield a latent space that effectively predicts outcomes relevant to the scientific question. Supervised Variational Autoencoders (SVAEs) have previously been used for this purpose, where a carefully designed decoder can be used as an interpretable generative model while the supervised objective ensures a predictive latent representation. Un…
Stanford University（斯坦福大学）；Facebook AI Research（Facebook人工智能研究院）
Variational autoencoders (VAE) are directed generative models that learn factorial latent variables. As noted by Burda et al. (2015), these models exhibit the problem of factor over-pruning where a significant number of stochastic factors fail to learn anything and become inactive. This can limit their modeling power and their ability to learn diverse and meaningful latent representations. In this paper, we evaluate several methods to address this problem and propose a more effective model-based approach called the epitomic variational autoencoder (eVAE). The so-called epitomes of this model a…
Modern machine learning systems achieve great success when trained on large datasets. However, these datasets usually contain sensitive information (e.g. medical records, face images), leading to serious privacy concerns. Differentially private generative models (DPGMs) emerge as a solution to circumvent such privacy concerns by generating privatized sensitive data. Similar to other differentially private (DP) learners, the major challenge for DPGM is also how to achieve a subtle balance between utility and privacy. We propose DP$^2$-VAE, a novel training mechanism for variational autoencoders…
National University of Singapore（新加坡国立大学）；Trustwave（Trustwave（特鲁斯特威）公司）
This paper looks into the problem of detecting network anomalies by analyzing NetFlow records. While many previous works have used statistical models and machine learning techniques in a supervised way, such solutions have the limitations that they require large amount of labeled data for training and are unlikely to detect zero-day attacks. Existing anomaly detection solutions also do not provide an easy way to explain or identify attacks in the anomalous traffic. To address these limitations, we develop and present GEE, a framework for detecting and explaining anomalies in network traffic. G…
In this paper we address the problem of enhancing speech signals in noisy mixtures using a source separation approach. We explore the use of neural networks as an alternative to a popular speech variance model based on supervised non-negative matrix factorization (NMF). More precisely, we use a variational autoencoder as a speaker-independent supervised generative speech model, highlighting the conceptual similarities that this approach shares with its NMF-based counterpart. In order to be free of generalization issues regarding the noisy recording environments, we follow the approach of havin…
Physiological monitoring in intensive care units (ICU) generates data that can be used in clinical research. However, the recording conditions in clinical settings limit the automated extraction of relevant information from physiological signals due to noise and artifacts. Therefore, removing artifacts before clinical research is essential. Manual annotation by experienced researchers, which is the gold standard for removing artifacts, is time-consuming and costly due to the volume of the data generated in the ICU. In this study, we propose a hybrid artifact detection system that combines a Va…
Georgia Institute of Technology（佐治亚理工学院）；Vanderbilt University（范德堡大学）；Sutter Health（萨特健康）
Access to electronic health record (EHR) data has motivated computational advances in medical research. However, various concerns, particularly over privacy, can limit access to and collaborative use of EHR data. Sharing synthetic EHR data could mitigate risk. In this paper, we propose a new approach, medical Generative Adversarial Network (medGAN), to generate realistic synthetic patient records. Based on input real patient records, medGAN can generate high-dimensional discrete variables (e.g., binary and count features) via a combination of an autoencoder and generative adversarial networks.…
One of the main problems with biomedical signals is the limited amount of patient-specific data and the significant amount of time needed to record the sufficient number of samples needed for diagnostic and treatment purposes. In this study, we present a framework to simultaneously generate and classify biomedical time series based on a modified Adversarial Autoencoder (AAE) algorithm and one-dimensional convolutions. Our work is based on breathing time series, with specific motivation to capture breathing motion during radiotherapy lung cancer treatments. First, we explore the potential in us…
IBM Research AI（IBM研究院人工智能部）；Thomas J. Watson Research Center（托马斯·J·沃森研究中心）
Noun phrases and Relation phrases in open knowledge graphs are not canonicalized, leading to an explosion of redundant and ambiguous subject-relation-object triples. Existing approaches to solve this problem take a two-step approach. First, they generate embedding representations for both noun and relation phrases, then a clustering algorithm is used to group them using the embeddings as features. In this work, we propose Canonicalizing Using Variational Autoencoders (CUVA), a joint model to learn both embeddings and cluster assignments in an end-to-end approach, which leads to a better vector…
Variational autoencoders trained to minimize the reconstruction error are sensitive to the posterior collapse problem, that is the proposal posterior distribution is always equal to the prior. We propose a novel regularization method based on fraternal dropout to prevent posterior collapse. We evaluate our approach using several metrics and observe improvements in all the tested configurations.
Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University（罗蒙诺索夫莫斯科国立大学斯科别利岑核物理研究所）；Applied Physics Institute of Irkutsk State University（伊尔库茨克国立大学应用物理研究所）；Lomonosov Moscow State University（罗蒙诺索夫莫斯科国立大学）
High-energy particles hitting the upper atmosphere of the Earth produce extensive air showers that can be detected from the ground level using imaging atmospheric Cherenkov telescopes. The images recorded by Cherenkov telescopes can be analyzed to separate gamma-ray events from the background hadron events. Many of the methods of analysis require simulation of massive amounts of events and the corresponding images by the Monte Carlo method. However, Monte Carlo simulation is computationally expensive. The data simulated by the Monte Carlo method can be augmented by images generated using faste…
Seoul National University（首尔大学）；Samsung Electronics Co. Ltd.（三星电子株式会社）
In this paper, we propose Squeezed Convolutional Variational AutoEncoder (SCVAE) for anomaly detection in time series data for Edge Computing in Industrial Internet of Things (IIoT). The proposed model is applied to labeled time series data from UCI datasets for exact performance evaluation, and applied to real world data for indirect model performance comparison. In addition, by comparing the models before and after applying Fire Modules from SqueezeNet, we show that model size and inference times are reduced while similar levels of performance is maintained.
EURECOM（欧洲通信研究院）；University of California, Irvine（加州大学欧文分校）
Autoencoders and their variants are among the most widely used models in representation learning and generative modeling. However, autoencoder-based models usually assume that the learned representations are i.i.d. and fail to capture the correlations between the data samples. To address this issue, we propose a novel Sparse Gaussian Process Bayesian Autoencoder (SGPBAE) model in which we impose fully Bayesian sparse Gaussian Process priors on the latent space of a Bayesian Autoencoder. We perform posterior estimation for this model via stochastic gradient Hamiltonian Monte Carlo. We evaluate …
Karlsruhe Institute of Technology（卡尔斯鲁厄理工学院）；Nokia（诺基亚）
We evaluate the start-up of blind equalizers at critical working points, analyze the advantages and obstacles of commonly-used algorithms, and demonstrate how the recently-proposed variational autoencoder (VAE) based equalizers can improve bootstrapping.
Deep generative models have achieved great success in unsupervised learning with the ability to capture complex nonlinear relationships between latent generating factors and observations. Among them, a factorized hierarchical variational autoencoder (FHVAE) is a variational inference-based model that formulates a hierarchical generative process for sequential data. Specifically, an FHVAE model can learn disentangled and interpretable representations, which have been proven useful for numerous speech applications, such as speaker verification, robust speech recognition, and voice conversion. Ho…
University of Technology Sydney（悉尼科技大学）；The Children’s Hospital at Westmead（韦斯特米德儿童医院）；Queen’s University at Kingston（金斯顿女王大学）
Feature extraction becomes increasingly important as data grows high dimensional. Autoencoder as a neural network based feature extraction method achieves great success in generating abstract features of high dimensional data. However, it fails to consider the relationships of data samples which may affect experimental results of using original and new features. In this paper, we propose a Relation Autoencoder model considering both data features and their relationships. We also extend it to work with other major autoencoder models including Sparse Autoencoder, Denoising Autoencoder and Variat…
Generative Adversarial Networks (GANs) have been used in many different applications to generate realistic synthetic data. We introduce a novel GAN with Autoencoder (GAN-AE) architecture to generate synthetic samples for variable length, multi-feature sequence datasets. In this model, we develop a GAN architecture with an additional autoencoder component, where recurrent neural networks (RNNs) are used for each component of the model in order to generate synthetic data to improve classification accuracy for a highly imbalanced medical device dataset. In addition to the medical device dataset, …
Adversarial attacks are malicious inputs that derail machine-learning models. We propose a scheme to attack autoencoders, as well as a quantitative evaluation framework that correlates well with the qualitative assessment of the attacks. We assess --- with statistically validated experiments --- the resistance to attacks of three variational autoencoders (simple, convolutional, and DRAW) in three datasets (MNIST, SVHN, CelebA), showing that both DRAW's recurrence and attention mechanism lead to better resistance. As autoencoders are proposed for compressing data --- a scenario in which their s…
Virginia Polytechnic Institute and State University (Virginia Tech)（弗吉尼亚理工学院暨州立大学（弗吉尼亚理工））
Deep learning models have demonstrated high-quality performance in areas such as image classification and speech processing. However, creating a deep learning model using electronic health record (EHR) data, requires addressing particular privacy challenges that are unique to researchers in this domain. This matter focuses attention on generating realistic synthetic data while ensuring privacy. In this paper, we propose a novel framework called correlation-capturing Generative Adversarial Network (CorGAN), to generate synthetic healthcare records. In CorGAN we utilize Convolutional Neural Netw…
Samsung AI Center Moscow（三星莫斯科人工智能中心）；Samsung-HSE Laboratory（三星-高等经济学院实验室）
We propose a single neural probabilistic model based on variational autoencoder that can be conditioned on an arbitrary subset of observed features and then sample the remaining features in "one shot". The features may be both real-valued and categorical. Training of the model is performed by stochastic variational Bayes. The experimental evaluation on synthetic data, as well as feature imputation and image inpainting problems, shows the effectiveness of the proposed approach and diversity of the generated samples.
We present an approach to quantify and compare the privacy-accuracy trade-off for differentially private Variational Autoencoders. Our work complements previous work in two aspects. First, we evaluate the the strong reconstruction MI attack against Variational Autoencoders under differential privacy. Second, we address the data scientist's challenge of setting privacy parameter epsilon, which steers the differential privacy strength and thus also the privacy-accuracy trade-off. In our experimental study we consider image and time series data, and three local and central differential privacy me…
Recently, a generative variational autoencoder (VAE) has been proposed for speech enhancement to model speech statistics. However, this approach only uses clean speech in the training phase, making the estimation particularly sensitive to noise presence, especially in low signal-to-noise ratios (SNRs). To increase the robustness of the VAE, we propose to include noise information in the training phase by using a noise-aware encoder trained on noisy-clean speech pairs. We evaluate our approach on real recordings of different noisy environments and acoustic conditions using two different noise d…
Variational inference for latent variable models is prevalent in various machine learning problems, typically solved by maximizing the Evidence Lower Bound (ELBO) of the true data likelihood with respect to a variational distribution. However, freely enriching the family of variational distribution is challenging since the ELBO requires variational likelihood evaluations of the latent variables. In this paper, we propose a novel framework to enrich the variational family by incorporating auxiliary variables to the variational family. The resulting inference network doesn't require density eval…
Université Paris Est（巴黎东部大学）；École des Ponts ParisTech（巴黎高科桥路学校）
Deep learning on graphs has become a popular research topic with many applications. However, past work has concentrated on learning graph embedding tasks, which is in contrast with advances in generative models for images and text. Is it possible to transfer this progress to the domain of graphs? We propose to sidestep hurdles associated with linearization of such discrete structures by having a decoder output a probabilistic fully-connected graph of a predefined maximum size directly at once. Our method is formulated as a variational autoencoder. We evaluate on the challenging task of molecul…
Singapore University of Technology and Design（新加坡科技设计大学）；Institute of High Performance Computing, A*STAR（新加坡科技研究局高性能计算研究所）；Yong Siew Toh Conservatory of Music, National University of Singapore（新加坡大学杨秀桃音乐学院）
In this paper, we learn disentangled representations of timbre and pitch for musical instrument sounds. We adapt a framework based on variational autoencoders with Gaussian mixture latent distributions. Specifically, we use two separate encoders to learn distinct latent spaces for timbre and pitch, which form Gaussian mixture components representing instrument identity and pitch, respectively. For reconstruction, latent variables of timbre and pitch are sampled from corresponding mixture components, and are concatenated as the input to a decoder. We show the model efficacy by latent space visu…
Increasing volume of Electronic Health Records (EHR) in recent years provides great opportunities for data scientists to collaborate on different aspects of healthcare research by applying advanced analytics to these EHR clinical data. A key requirement however is obtaining meaningful insights from high dimensional, sparse and complex clinical data. Data science approaches typically address this challenge by performing feature learning in order to build more reliable and informative feature representations from clinical data followed by supervised learning. In this paper, we propose a predicti…
Increasing volume of Electronic Health Records (EHR) in recent years provides great opportunities for data scientists to collaborate on different aspects of healthcare research by applying advanced analytics to these EHR clinical data. A key requirement however is obtaining meaningful insights from high dimensional, sparse and complex clinical data. Data science approaches typically address this challenge by performing feature learning in order to build more reliable and informative feature representations from clinical data followed by supervised learning. In this paper, we propose a predicti…
Computing power, big data, and advancement of algorithms have led to a renewed interest in artificial intelligence (AI), especially in deep learning (DL). The success of DL largely lies on data representation because different representations can indicate to a degree the different explanatory factors of variation behind the data. In the last few year, the most successful story in DL is supervised learning. However, to apply supervised learning, one challenge is that data labels are expensive to get, noisy, or only partially available. With consideration that we human beings learn in an unsuper…
An adversarial autoencoder conditioned on known parameters of a physical modeling bowed string synthesizer is evaluated for use in parameter estimation and resynthesis tasks. Latent dimensions are provided to capture variance not explained by the conditional parameters. Results are compared with and without the adversarial training, and a system capable of "copying" a given parameter-signal bidirectional relationship is examined. A real-time synthesis system built on a generative, conditioned and regularized neural network is presented, allowing to construct engaging sound synthesizers based p…
University of Illinois at Chicago（伊利诺伊大学芝加哥分校）；Amazon（亚马逊）；Northwestern University（西北大学）
Distributed representations have been used to support downstream tasks in healthcare recently. Healthcare data (e.g., electronic health records) contain multiple modalities of data from heterogeneous sources that can provide complementary information, alongside an added dimension to learning personalized patient representations. To this end, in this paper we propose a novel unsupervised encoder-decoder model, namely Mixed Pooling Multi-View Attention Autoencoder (MPVAA), that generates patient representations encapsulating a holistic view of their medical profile. Specifically, by first learni…
Stacked denoising autoencoders (SDAs) have been successfully used to learn new representations for domain adaptation. Recently, they have attained record accuracy on standard benchmark tasks of sentiment analysis across different text domains. SDAs learn robust data representations by reconstruction, recovering original features from data that are artificially corrupted with noise. In this paper, we propose marginalized SDA (mSDA) that addresses two crucial limitations of SDAs: high computational cost and lack of scalability to high-dimensional features. In contrast to SDAs, our approach of mS…
Solvay Business School（索尔维商学院）；Vrije Universiteit Brussel（布鲁塞尔自由大学）；Antwerp Management School（安特卫普管理学院）；Universiteit Antwerpen（安特卫普大学）；Faculty of Business and Economics（商业与经济学院）；Katholieke Universiteit Leuven（鲁汶大学）
In the majority of executive domains, a notion of normality is involved in most strategic decisions. However, few data-driven tools that support strategic decision-making are available. We introduce and extend the use of autoencoders to provide strategically relevant granular feedback. A first experiment indicates that experts are inconsistent in their decision making, highlighting the need for strategic decision support. Furthermore, using two large industry-provided human resources datasets, the proposed solution is evaluated in terms of ranking accuracy, synergy with human experts, and dime…
Seoul National University（首尔国立大学）；Samsung Electronics Co. Ltd.（三星电子有限公司）；Seoul National University College of Medicine（首尔国立大学医学院）
Electronic health records (EHRs) have contributed to the computerization of patient records and can thus be used not only for efficient and systematic medical services, but also for research on biomedical data science. However, there are many missing values in EHRs when provided in matrix form, which is an important issue in many biomedical EHR applications. In this paper, we propose a two-stage framework that includes missing data imputation and disease prediction to address the missing data problem in EHRs. We compared the disease prediction performance of generative adversarial networks (GA…
