双稳到四稳：宿主-电路耦合下混合表型的出现及时空可塑性的增强
Bistability to Quad-stability: Emergence of Hybrid Phenotypes & Enhanced Spatio-temporal Plasticity in Presence of Host-Circuit Coupling
AI总结：
研究发现宿主-电路耦合下双稳态遗传电路在资源竞争和生长反馈作用下产生多种表型，并增强时空可塑性，为癌症转移和进展提供新见解。
摘要：
在由多稳态驱动的疾病，如癌症中，时空可塑性在实现表型变异的谱中起着重要作用。基因调控网络与环境因素，如资源竞争和空间扩散之间的相互作用在确定细胞行为和表型异质性中起着关键作用。尽管反应扩散框架已被广泛应用于发育生物学，但对资源竞争和生长反馈同时影响空间组织的效应关注较少。在本文中，我们观察到由于生长反馈导致的高资源竞争下双稳态遗传电路会产生多种涌现表型，如癌症系统中所观察到的。此外，我们还观察到空间扩散与内在非线性如何随时间驱动不同空间动态的出现。所观察到的时空可塑性也可以由固定点的相对稳定性、扩散性以及扩散的不对称性驱动。我们的发现强调了由生长引起的资源竞争与扩散结合，可以为转移和癌症进展提供更深入的见解。
英文摘要：
In the context of multistability driven diseases, like cancer, spatiotemporal plasticity plays a significant role to achieve a spectrum of phenotypic variations. The interplay between gene regulatory networks and environmental factors, such as resource competition and spatial diffusion, plays a crucial role in determining cellular behaviour and phenotypic heterogeneity. Though reaction diffusion frameworks have been widely applied in developmental biology, less attention has been paid to the simultaneous effects of resource competition and growth feedback on spatial organization. In this paper, we observed that a bistable genetic circuit under high resource competition due to growth feedback gives rise to multiple emergent phenotypes, as observed in cancer systems. Furthermore, we observed how spatial diffusion coupled with intrinsic nonlinearity can drive the emergence of distinct spatial dynamics over time. The observed spatiotemporal plasticity can also be driven by the comparative stability of the fixed points, diffusivity, and asymmetry of diffusion. Our findings highlight that growth-induced resource competition combined with diffusion can provide deeper insights into metastasis and cancer progression.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
