表型可塑性、遗传和表观遗传波动、鲁棒性和可进化性之间的关系;在爱因斯坦精神下重温沃丁顿的遗产
Relationship among Phenotypic Plasticity, Genetic and Epigenetic Fluctuations, Robustness, and Evolovability; Waddington's Legacy revisited under the Spirit of Einstein
摘要：
表型可塑性与可进化性、健壮性与进化之间可能存在的关系是进化-发育领域几十年来研究的热点问题。通过引入一个进化稳定性假设的分布表型和基因型，我们建立了可塑性，表型波动和可进化性的定量关系。推导出可塑性作为表型对环境变化的反应，遗传和发育起源的表型波动的方差，以及进化速度之间的比例关系。确认的关系给出了一个基因表达动力学模型与不断发展的转录网络的数值实验，而实验室进化实验的验证也进行了讨论。这些结果提供了渠道化和遗传同化的定量公式，在基因表达水平的波动。
英文摘要：
Questions on possible relationship between phenotypic plasticity and evolvability, as well as that between robustness and evolution have been addressed over decades in the field of evolution-development. By introducing an evolutionary stability assumption on the distribution of phenotype and genotype, we establish quantitative relationships on plasticity, phenotypic fluctuations, and evolvability. Derived are proportionality among plasticity as a responsiveness of phenotype against environmental change, variances of phenotype fluctuations of genetic and developmental origins, and evolution speed. Confirmation of the relationships is given by numerical experiments of a gene expression dynamics model with an evolving transcription network, whereas verifications by laboratory evolution experiments are also discussed. These results provide quantitative formulation on canalization and genetic assimilation, in terms of fluctuations of gene expression levels.
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