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arXiv 2602.12883eess.IVcs.CV
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双相跨模态对比学习用于CMR引导的ECG表示以评估心血管疾病

Dual-Phase Cross-Modal Contrastive Learning for CMR-Guided ECG Representations for Cardiovascular Disease Assessment

Amsterdam University Medical Center(阿姆斯特丹大学医学中心);University of Amsterdam(阿姆斯特丹大学);ETH Zurich(苏黎世联邦理工学院);Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center(放射医学与核医学系,阿姆斯特丹大学医学中心);Department of Radiology, Mayo Clinic, Rochester(放射医学系,梅奥诊所,罗切斯特)
Laura Alvarez-Florez, Angel Bujalance-Gomez, Femke Raijmakers, Samuel Ruiperez-Campillo, Maarten Z. H. Kolk, Jesse Wiers, Julia Vogt, Erik J. Bekkers, Ivana Išg… 展开作者

Laura Alvarez-Florez, Angel Bujalance-Gomez, Femke Raijmakers, Samuel Ruiperez-Campillo, Maarten Z. H. Kolk, Jesse Wiers, Julia Vogt, Erik J. Bekkers, Ivana Išgum, Fleur V. Y. Tjong

AI总结:

本文提出双相跨模态对比学习方法,通过结合ECG和CMR数据提升心血管疾病评估的ECG表示能力。

摘要:

心脏磁共振成像(CMR)提供了对心脏结构和功能的详细评估,但其有限的可及性限制了其在特定患者群体中的使用。相比之下,心电图(ECG)是普遍且经济的,提供了关于心脏电信号和节律的丰富信息,但对心脏结构和机械功能的深入理解有限。为此,我们引入了一种对比学习框架,通过学习配对的ECG-CMR数据来提高从ECG中提取临床相关心脏表型的能力。我们的方法在舒张末期(ED)和收缩末期(ES)将ECG表示与3D CMR体积对齐,并采用双相对比损失将每个ECG与两个心脏阶段在共享潜在空间中锚定。与以往仅限于2D CMR表示(带或不带时间成分)的方法不同,我们的框架将ED和ES阶段的3D解剖结构建模为不同的潜在表示,从而能够灵活地解耦结构性和功能性的心脏属性。使用超过34,000对UK Biobank的ECG-CMR数据,我们展示了从ECG中改进提取图像派生表型的能力,特别是功能参数(上升9.2%),而临床结果预测的改进则保持适度(上升0.7%)。这种策略可能能够实现大规模且经济高效的从ECG中提取图像派生特征。本研究的代码已公开可用。

英文摘要:

Cardiac magnetic resonance imaging (CMR) offers detailed evaluation of cardiac structure and function, but its limited accessibility restricts use to selected patient populations. In contrast, the electrocardiogram (ECG) is ubiquitous and inexpensive, and provides rich information on cardiac electrical activity and rhythm, yet offers limited insight into underlying cardiac structure and mechanical function. To address this, we introduce a contrastive learning framework that improves the extraction of clinically relevant cardiac phenotypes from ECG by learning from paired ECG-CMR data. Our approach aligns ECG representations with 3D CMR volumes at end-diastole (ED) and end-systole (ES), with a dual-phase contrastive loss to anchor each ECG jointly with both cardiac phases in a shared latent space. Unlike prior methods limited to 2D CMR representations with or without a temporal component, our framework models 3D anatomy at both ED and ES phases as distinct latent representations, enabling flexible disentanglement of structural and functional cardiac properties. Using over 34,000 ECG-CMR pairs from the UK Biobank, we demonstrate improved extraction of image-derived phenotypes from ECG, particularly for functional parameters ($\uparrow$ 9.2\%), while improvements in clinical outcome prediction remained modest ($\uparrow$ 0.7\%). This strategy could enable scalable and cost-effective extraction of image-derived traits from ECG. The code for this research is publicly available.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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