Early Alzheimer's Disease Detection from Retinal OCT Images: A UK Biobank Study
Department of Computer Engineering Isik University Istanbul, Turkey（计算机工程系伊斯肯大学）；Department of Artificial Intelligence and Data Engineering（人工智能与数据工程系）；Data Engineering Istanbul Technical University Istanbul, Turkey（数据工程系伊斯坦布尔技术大学）
Yasemin Turkan, F. Boray Tek, M. Serdar Nazlı, Öykü Eren
Alterations in retinal layer thickness, measurable using Optical Coherence Tomography (OCT), have been associated with neurodegenerative diseases such as Alzheimer's disease (AD). While previous studies have mainly focused on segmented layer thickness measurements, this study explored the direct classification of OCT B-scan images for the early detection of AD. To our knowledge, this is the first application of deep learning to raw OCT B-scans for AD prediction in the literature. Unlike conventional medical image classification tasks, early detection is more challenging than diagnosis because imaging precedes clinical diagnosis by several years. We fine-tuned and evaluated multiple pretrained models, including ImageNet-based networks and the OCT-specific RETFound transformer, using subject-level cross-validation datasets matched for age, sex, and imaging instances from the UK Biobank cohort. To reduce overfitting in this small, high-dimensional dataset, both standard and OCT-specific augmentation techniques were applied, along with a year-weighted loss function that prioritized cases diagnosed within four years of imaging. ResNet-34 produced the most stable results, achieving an AUC of 0.62 in the 4-year cohort. Although below the threshold for clinical application, our explainability analyses confirmed localized structural differences in the central macular subfield between the AD and control groups. These findings provide a baseline for OCT-based AD prediction, highlight the challenges of detecting subtle retinal biomarkers years before AD diagnosis, and point to the need for larger datasets and multimodal approaches.
Prediction of Alzheimer's Disease Risk Factors from Retinal Images via Deep Learning: Development and Validation of Biologically Relevant Morphological Associations in the UK Biobank
J. Crayton Pruitt Family Dept. of Biomedical Engineering, University of Florida（朱·克雷顿·普瑞特生物医学工程系，佛罗里达大学）；University of Florida Research Computing（佛罗里达大学研究计算中心）；Meta AI (FAIR)（Meta AI（FAIR））；School of Behavioral and Brain Sciences, University of Texas at Dallas（德克萨斯大学达拉斯分校行为与脑科学学院）；Dept. of Electrical and Computer Engineering, University of Florida（佛罗里达大学电气与计算机工程系）；Dept. of Computer and Information Science and Engineering, University of Florida（佛罗里达大学计算机与信息科学与工程系）；Center for Cognitive Aging and Memory, University of Florida（佛罗里达大学认知衰老与记忆中心）
Google Research（谷歌研究院）；Google DeepMind（谷歌DeepMind）；NIHR Biomedical Research Centre for Ophthalmology（NIHR眼科生物医学研究中心）；Moorfields Eye Hospital NHS Foundation Trust（摩尔菲尔德眼科医院NHS基金会信托）；UCL Institute of Ophthalmology（伦敦大学学院眼科研究所）
Refractive error, one of the leading cause of visual impairment, can be corrected by simple interventions like prescribing eyeglasses. We trained a deep learning algorithm to predict refractive error from the fundus photographs from participants in the UK Biobank cohort, which were 45 degree field of view images and the AREDS clinical trial, which contained 30 degree field of view images. Our model use the "attention" method to identify features that are correlated with refractive error. Mean absolute error (MAE) of the algorithm's prediction compared to the refractive error obtained in the AR…
University of Bern（伯尔尼大学）；University Hospital of Bern（伯尔尼大学医院）
Optical Coherence Tomography (OCT) is the primary imaging modality for detecting pathological biomarkers associated to retinal diseases such as Age-Related Macular Degeneration. In practice, clinical diagnosis and treatment strategies are closely linked to biomarkers visible in OCT volumes and the ability to identify these plays an important role in the development of ophthalmic pharmaceutical products. In this context, we present a method that automatically predicts the presence of biomarkers in OCT cross-sections by incorporating information from the entire volume. We do so by adding a bidir…
OCTDL: Optical Coherence Tomography Dataset for Image-Based Deep Learning Methods
Friedrich-Alexander-Universität Erlangen-Nürnberg（弗里德里希-亚历山大-埃尔朗根-纽伦堡大学）；Ural Federal University Named after the First President of Russia B. N. Yeltsin（俄罗斯首任总统B.N.叶利钦命名的乌拉尔联邦大学）；Ophthalmosurgery Clinic "Professorskaya Plus"（“Professorskaya Plus”眼科诊所）；Ural State Medical University（乌拉尔国立医科大学）
Retinal Optical Coherence Tomography (OCT), a noninvasive cross-sectional scan of the eye with qualitative 3D visualization of the retinal anatomy is use to study the retinal structure and the presence of pathogens. The advent of the retinal OCT has transformed ophthalmology and it is currently paramount for the diagnosis, monitoring and treatment of many eye pathogens including Macular Edema which impairs vision severely or Glaucoma that can cause irreversible blindness. However the quality of retinal OCT images varies among device manufacturers. Deep Learning methods have had their success i…
University of Nottingham（诺丁汉大学）；Shenzhen University（深圳大学）；Wuhan University of Technology（武汉理工大学）；University of Leicester（莱斯特大学）
In this paper, we propose a novel retinal layer boundary model for segmentation of optical coherence tomography (OCT) images. The retinal layer boundary model consists of 9 open parametric contours representing the 9 retinal layers in OCT images. An intensity-based Mumford-Shah (MS) variational functional is first defined to evolve the retinal layer boundary model to segment the 9 layers simultaneously. By making use of the normals of open parametric contours, we construct equal sized adjacent narrowbands that are divided by each contour. Regional information in each narrowband can thus be int…
University of Oxford（牛津大学）；Big Data Institute, University of Oxford（牛津大学大数据研究所）；School of Engineering, Newcastle University（纽卡斯尔大学工程学院）；Neura Health Group；Newcastle Eye Centre, Royal Victoria Infirmary（纽卡斯尔皇家维多利亚医院纽卡斯尔眼科中心）；Newcastle University（纽卡斯尔大学）；Newcastle Upon Tyne, UK（泰恩河畔纽卡斯尔（英国））
Optical coherence tomography (OCT) is a commonly-used method of extracting high resolution retinal information. Moreover there is an increasing demand for the automated retinal layer segmentation which facilitates the retinal disease diagnosis. In this paper, we propose a novel multiprediction guided attention network (MPG-Net) for automated retinal layer segmentation in OCT images. The proposed method consists of two major steps to strengthen the discriminative power of a U-shape Fully convolutional network (FCN) for reliable automated segmentation. Firstly, the feature refinement module whic…
Casey Eye Institute, Oregon Health & Science University（俄勒冈健康与科学大学凯西眼科研究所）；School of Physics and Optoelectronic Engineering, Foshan University（佛山大学物理与光电工程学院）；Department of Biomedical Engineering, Oregon Health & Science University（俄勒冈健康与科学大学生物医学工程系）
Purpose: We proposed a deep convolutional neural network (CNN), named Retinal Fluid Segmentation Network (ReF-Net) to segment volumetric retinal fluid on optical coherence tomography (OCT) volume. Methods: 3 x 3-mm OCT scans were acquired on one eye by a 70-kHz OCT commercial AngioVue system (RTVue-XR; Optovue, Inc.) from 51 participants in a clinical diabetic retinopathy (DR) study (45 with retinal edema and 6 healthy controls). A CNN with U-Net-like architecture was constructed to detect and segment the retinal fluid. Cross-sectional OCT and angiography (OCTA) scans were used for training an…
We analyze a dataset of retinal images using linear probes: linear regression models trained on some "target" task, using embeddings from a deep convolutional (CNN) model trained on some "source" task as input. We use this method across all possible pairings of 93 tasks in the UK Biobank dataset of retinal images, leading to ~164k different models. We analyze the performance of these linear probes by source and target task and by layer depth. We observe that representations from the middle layers of the network are more generalizable. We find that some target tasks are easily predicted irrespe…
Khulna University of Engineering and Technology（库尔纳工程技术大学）
In medical science, the use of computer science in disease detection and diagnosis is gaining popularity. Previously, the detection of disease used to take a significant amount of time and was less reliable. Machine learning (ML) techniques employed in recent biomedical researches are making revolutionary changes by gaining higher accuracy with more concise timing. At present, it is even possible to automatically detect diseases from the scanned images with the help of ML. In this research, we have taken such an attempt to detect retinal diseases from optical coherence tomography (OCT) X-ray i…
3D imaging modalities are becoming increasingly popular and relevant in retinal imaging owing to their effectiveness in highlighting structures in sub-retinal layers. OCT is one such modality which has great importance in the context of analysis of cystoid structures in subretinal layers. Signal to noise ratio(SNR) of the images obtained from OCT is less and hence automated and accurate determination of cystoid structures from OCT is a challenging task. We propose an automated method for detecting/segmenting cysts in 3D OCT volumes. The proposed method is biologically inspired and fast aided b…
Recent contrastive learning methods achieved state-of-the-art in low label regimes. However, the training requires large batch sizes and heavy augmentations to create multiple views of an image. With non-contrastive methods, the negatives are implicitly incorporated in the loss, allowing different images and modalities as pairs. Although the meta-information (i.e., age, sex) in medical imaging is abundant, the annotations are noisy and prone to class imbalance. In this work, we exploited already existing temporal information (different visits from a patient) in a longitudinal optical coherence…
Optical Coherence Tomography (OCT) is an emerging technique in the field of biomedical imaging, with applications in ophthalmology, dermatology, coronary imaging etc. Due to the underlying physics, OCT images usually suffer from a granular pattern, called speckle noise, which restricts the process of interpretation. Here, a sparse and low rank decomposition based method is used for speckle reduction in retinal OCT images. This technique works on input data that consists of several B-scans of the same location. The next step is the batch alignment of the images using a sparse and low-rank decom…
University of Bern（伯尔尼大学）；RetinAI Medical GmbH（RetinAI Medical 公司）；Bern University Hospital（伯尔尼大学医院）
The automatic segmentation of retinal layer structures enables clinically-relevant quantification and monitoring of eye disorders over time in OCT imaging. Eyes with late-stage diseases are particularly challenging to segment, as their shape is highly warped due to pathological biomarkers. In this context, we propose a novel fully Convolutional Neural Network (CNN) architecture which combines dilated residual blocks in an asymmetric U-shape configuration, and can segment multiple layers of highly pathological eyes in one shot. We validate our approach on a dataset of late-stage AMD patients an…
The identification and quantification of markers in medical images is critical for diagnosis, prognosis, and disease management. Supervised machine learning enables the detection and exploitation of findings that are known a priori after annotation of training examples by experts. However, supervision does not scale well, due to the amount of necessary training examples, and the limitation of the marker vocabulary to known entities. In this proof-of-concept study, we propose unsupervised identification of anomalies as candidates for markers in retinal Optical Coherence Tomography (OCT) imaging…
FaraAI Company（法拉人工智能公司）；University of Tehran（德黑兰大学）
Optical coherence tomography (OCT) imaging is a well-known technology for visualizing retinal layers and helps ophthalmologists to detect possible diseases. Accurate and early diagnosis of common retinal diseases can prevent the patients from suffering critical damages to their vision. Computer-aided diagnosis (CAD) systems can significantly assist ophthalmologists in improving their examinations. This paper presents a new enhanced deep ensemble convolutional neural network for detecting retinal diseases from OCT images. Our model generates rich and multi-resolution features by employing the l…
OCTCube-M: A 3D multimodal optical coherence tomography foundation model for retinal and systemic diseases with cross-cohort and cross-device validation
According to the World Health Organization, 285 million people worldwide live with visual impairment. The most commonly used imaging technique for diagnosis in ophthalmology is optical coherence tomography (OCT). However, analysis of retinal OCT requires trained ophthalmologists and time, making a comprehensive early diagnosis unlikely. A recent study established a diagnostic tool based on convolutional neural networks (CNN), which was trained on a large database of retinal OCT images. The performance of the tool in classifying retinal conditions was on par to that of trained medical experts. …
The Pingry School（平格里学校）；Chinle Comprehensive Health Care Facility（钦利综合医疗中心）；University of Maryland, College Park（马里兰大学帕克分校）；NVIDIA（英伟达）
30 million Optical Coherence Tomography (OCT) imaging tests are issued annually to diagnose various retinal diseases, but accurate diagnosis of OCT scans requires trained eye care professionals who are still prone to making errors. With better systems for diagnosis, many cases of vision loss caused by retinal disease could be entirely avoided. In this work, we present ReLaX, a novel deep learning framework for explainable, accurate classification of retinal pathologies which achieves state-of-the-art accuracy. Furthermore, we emphasize producing both qualitative and quantitative explanations o…
Optical coherence tomography (OCT) is a prevalent non-invasive imaging method which provides high resolution volumetric visualization of retina. However, its inherent defect, the speckle noise, can seriously deteriorate the tissue visibility in OCT. Deep learning based approaches have been widely used for image restoration, but most of these require a noise-free reference image for supervision. In this study, we present a diffusion probabilistic model that is fully unsupervised to learn from noise instead of signal. A diffusion process is defined by adding a sequence of Gaussian noise to self-…
Optical Coherence Tomography (OCT) is an emerging technique in the field of biomedical imaging, with applications in ophthalmology, dermatology, coronary imaging etc. OCT images usually suffer from a granular pattern, called speckle noise, which restricts the process of interpretation. Therefore the need for speckle noise reduction techniques is of high importance. To the best of our knowledge, use of Independent Component Analysis (ICA) techniques has never been explored for speckle reduction of OCT images. Here, a comparative study of several ICA techniques (InfoMax, JADE, FastICA and SOBI) …
Nanjing University of Science and Technology（南京理工大学）
Optical coherence tomography angiography (OCTA) is a novel imaging modality that has been widely utilized in ophthalmology and neuroscience studies to observe retinal vessels and microvascular systems. However, publicly available OCTA datasets remain scarce. In this paper, we introduce the largest and most comprehensive OCTA dataset dubbed OCTA-500, which contains OCTA imaging under two fields of view (FOVs) from 500 subjects. The dataset provides rich images and annotations including two modalities (OCT/OCTA volumes), six types of projections, four types of text labels (age / gender / eye / d…
In medical imaging, there are clinically relevant segmentation tasks where the output mask is a projection to a subset of input image dimensions. In this work, we propose a novel convolutional neural network architecture that can effectively learn to produce a lower-dimensional segmentation mask than the input image. The network restores encoded representation only in a subset of input spatial dimensions and keeps the representation unchanged in the others. The newly proposed projective skip-connections allow linking the encoder and decoder in a UNet-like structure. We evaluated the proposed m…
Cixi Institute of Biomedical Engineering, Ningbo Institute of Industrial Technology, Chinese Academy of Sciences（中国科学院宁波工业技术研究院慈溪生物医学工程研究所）；Inception Institute of Artificial Intelligence（起源人工智能研究院）；Keck School of Medicine, University of Southern California（南加州大学凯克医学院）；First Affiliated Hospital of Wenzhou Medical University（温州医科大学附属第一医院）；Southern University of Science and Technology（南方科技大学）；University of Liverpool（利物浦大学）
Optical Coherence Tomography Angiography (OCT-A) is a non-invasive imaging technique, and has been increasingly used to image the retinal vasculature at capillary level resolution. However, automated segmentation of retinal vessels in OCT-A has been under-studied due to various challenges such as low capillary visibility and high vessel complexity, despite its significance in understanding many eye-related diseases. In addition, there is no publicly available OCT-A dataset with manually graded vessels for training and validation. To address these issues, for the first time in the field of reti…
Optical coherence tomography (OCT) scanning is useful in detecting various retinal diseases. However, there are not enough ophthalmologists who can diagnose retinal OCT images in much of the world. To provide OCT screening inexpensively and extensively, an automated diagnosis system is indispensable. Although many machine learning techniques have been presented for assisting ophthalmologists in diagnosing retinal OCT images, there is no technique that can diagnose independently without relying on an ophthalmologist, i.e., there is no technique that does not overlook any anomaly, including unle…
Medical University of Vienna（维也纳医科大学）；Medical University Vienna（维也纳医科大学）
Optical coherence tomography (OCT) has become the most important imaging modality in ophthalmology. A substantial amount of research has recently been devoted to the development of machine learning (ML) models for the identification and quantification of pathological features in OCT images. Among the several sources of variability the ML models have to deal with, a major factor is the acquisition device, which can limit the ML model's generalizability. In this paper, we propose to reduce the image variability across different OCT devices (Spectralis and Cirrus) by using CycleGAN, an unsupervis…
University of Isfahan（伊斯法罕大学）；Duke University（杜克大学）；Duke University Medical Center（杜克大学医学中心）
Optical coherence tomography (OCT) helps ophthalmologists assess macular edema, accumulation of fluids, and lesions at microscopic resolution. Quantification of retinal fluids is necessary for OCT-guided treatment management, which relies on a precise image segmentation step. As manual analysis of retinal fluids is a time-consuming, subjective, and error-prone task, there is increasing demand for fast and robust automatic solutions. In this study, a new convolutional neural architecture named RetiFluidNet is proposed for multi-class retinal fluid segmentation. The model benefits from hierarchi…
Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡大学）；Massachusetts Institute of Technology（麻省理工学院）
Optical coherence tomography (OCT) enables high-resolution and non-invasive 3D imaging of the human retina but is inherently impaired by speckle noise. This paper introduces a spatio-temporal denoising algorithm for OCT data on a B-scan level using a novel quantile sparse image (QuaSI) prior. To remove speckle noise while preserving image structures of diagnostic relevance, we implement our QuaSI prior via median filter regularization coupled with a Huber data fidelity model in a variational approach. For efficient energy minimization, we develop an alternating direction method of multipliers …
Optical coherence tomography (OCT) is a non-invasive imaging modality which is widely used in clinical ophthalmology. OCT images are capable of visualizing deep retinal layers which is crucial for early diagnosis of retinal diseases. In this paper, we describe a comprehensive open-access database containing more than 500 highresolution images categorized into different pathological conditions. The image classes include Normal (NO), Macular Hole (MH), Age-related Macular Degeneration (AMD), Central Serous Retinopathy (CSR), and Diabetic Retinopathy (DR). The images were obtained from a raster s…
Medical University Vienna（维也纳医科大学）；Department of Biomedical Imaging and Image-guided Therapy, Computational Imaging Research Lab, Medical University Vienna, Austria（维也纳医科大学生物医学成像与影像引导治疗系计算成像研究实验室）；Christian Doppler Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University Vienna, Austria（维也纳医科大学眼科与视光学系眼科图像分析基督教多普勒实验室）；Department of Ophthalmology and Optometry, Medical University Vienna, Austria（维也纳医科大学眼科与视光学系）
The automatic detection of disease related entities in retinal imaging data is relevant for disease- and treatment monitoring. It enables the quantitative assessment of large amounts of data and the corresponding study of disease characteristics. The presence of hyperreflective foci (HRF) is related to disease progression in various retinal diseases. Manual identification of HRF in spectral-domain optical coherence tomography (SD-OCT) scans is error-prone and tedious. We present a fully automated machine learning approach for segmenting HRF in SD-OCT scans. Evaluation on annotated OCT images o…
This paper presents a novel automated system that segments six sub-retinal layers from optical coherence tomography (OCT) image stacks of healthy patients and patients with diabetic macular edema (DME). First, each image in the OCT stack is denoised using a Wiener deconvolution algorithm that estimates the additive speckle noise variance using a novel Fourier-domain based structural error. This denoising method enhances the image SNR by an average of 12dB. Next, the denoised images are subjected to an iterative multi-resolution high-pass filtering algorithm that detects seven sub-retinal surfa…
Pretrained Deep 2.5D Models for Efficient Predictive Modeling from Retinal OCT
University of Basel（巴塞尔大学）；Technical University Munich（慕尼黑工业大学）；Medical University of Vienna（维也纳医科大学）；Moorfields Eye Hospital NHS Foundation Trust（摩尔菲尔斯眼科医院NHS基金会信托）；Imperial College London（帝国理工学院）；Institute of Molecular and Clinical Ophthalmology Basel（巴塞尔分子与临床眼科研究所）；University of Southampton（南安普顿大学）
Simultaneous column-based deep learning progression analysis of atrophy associated with AMD in longitudinal OCT studies
School of Computer Science and Engineering, The Hebrew University of Jerusalem（耶路撒冷希伯来大学计算机科学与工程学院）；The Alexander Grass Center for Bioengineering, The Hebrew University of Jerusalem（耶路撒冷希伯来大学亚历山大·格拉斯生物工程中心）；Hadassah Medical Center（哈达萨医疗中心）
With the introduction of spectral-domain optical coherence tomography (SDOCT), much larger image datasets are routinely acquired compared to what was possible using the previous generation of time-domain OCT. Thus, there is a critical need for the development of 3D segmentation methods for processing these data. We present here a novel 3D automatic segmentation method for retinal OCT volume data. Briefly, to segment a boundary surface, two OCT volume datasets are obtained by using a 3D smoothing filter and a 3D differential filter. Their linear combination is then calculated to generate new vo…
University of Heidelberg（海德堡大学）；Heidelberg Engineering GmbH（海德堡工程有限公司）
With the introduction of spectral-domain optical coherence tomography (OCT), resulting in a significant increase in acquisition speed, the fast and accurate segmentation of 3-D OCT scans has become evermore important. This paper presents a novel probabilistic approach, that models the appearance of retinal layers as well as the global shape variations of layer boundaries. Given an OCT scan, the full posterior distribution over segmentations is approximately inferred using a variational method enabling efficient probabilistic inference in terms of computationally tractable model components: Seg…
Segmentation of retinal layers from Optical Coherence Tomography (OCT) volumes is a fundamental problem for any computer aided diagnostic algorithm development. This requires preprocessing steps such as denoising, region of interest extraction, flattening and edge detection all of which involve separate parameter tuning. In this paper, we explore deep learning techniques to automate all these steps and handle the presence/absence of pathologies. A model is proposed consisting of a combination of Convolutional Neural Network (CNN) and Long Short Term Memory (LSTM). The CNN is used to extract la…
LUMOS: Universal Semi-Supervised OCT Retinal Layer Segmentation with Hierarchical Reliable Mutual Learning
Southern University of Science and Technology（南方科技大学）；Shenzhen Loop Area Institute（深圳河套学院）；Jiaxing Research Institute, Southern University of Science and Technology（南方科技大学嘉兴研究院）
Fundus-Enhanced Disease-Aware Distillation Model for Retinal Disease Classification from OCT Images
The Hong Kong University of Science and Technology（香港科技大学）；Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine（广东省中西医结合医院）；Guangdong Weiren Meditech Co., Ltd（广东唯仁医疗科技有限公司）
Predicting risk of cardiovascular disease using retinal OCT imaging
University of Leeds（利兹大学）；Research Institute for Signals, Systems and Computational Intelligence（信号、系统与计算智能研究所）；CONICET-UNL（阿根廷科学技术研究委员会-国立洛马大学）；University of Manchester（曼彻斯特大学）；Manchester University NHS Foundation Trust（曼彻斯特大学NHS基金会信托基金）；European Molecular Biology Laboratory（欧洲分子生物学实验室）；European Bioinformatics Institute (EMBL-EBI)（欧洲生物信息研究所）；NIHR Manchester Biomedical Research Centre（NIHR曼彻斯特生物医学研究中心）；Manchester Academic Health Science Centre（曼彻斯特学术健康科学中心）
提出基于 VAE 与随机森林的视网膜 OCT 自监督方法，结合临床数据预测心肌梗死或卒中风险，性能优于 QRISK3，并揭示脉络膜层为关键特征。
Despite its high prevalence, anemia is often undetected due to the invasiveness and cost of screening and diagnostic tests. Though some non-invasive approaches have been developed, they are less accurate than invasive methods, resulting in an unmet need for more accurate non-invasive methods. Here, we show that deep learning-based algorithms can detect anemia and quantify several related blood measurements using retinal fundus images both in isolation and in combination with basic metadata such as patient demographics. On a validation dataset of 11,388 patients from the UK Biobank, our algorit…
SD-RetinaNet: Topologically Constrained Semi-Supervised Retinal Lesion and Layer Segmentation in OCT
Christian Doppler Laboratory for Artificial Intelligence in Retina（基督教多普勒人工智能视网膜实验室）；Institute of Artificial Intelligence（人工智能研究所）；Center for Medical Data Science（医学数据科学中心）；Medical University of Vienna（维也纳医学大学）；Computational Imaging Research Lab（计算成像研究实验室）；Department of Biomedical Imaging and Image-Guided Therapy（生物医学成像与影像引导治疗部门）；Department of Ophthalmology and Optometry（眼科与视光学部门）
Simultaneous Alignment and Surface Regression Using Hybrid 2D-3D Networks for 3D Coherent Layer Segmentation of Retinal OCT Images with Full and Sparse Annotations
Xiamen University（厦门大学）；National Institute for Data Science in Health and Medicine, Xiamen University（厦门大学健康医疗大数据国家研究院）；Tencent YouTu Lab（腾讯优图实验室）；Southern University of Science and Technology（南方科技大学）
Optical coherence tomography (OCT) is commonly used to analyze retinal layers for assessment of ocular diseases. In this paper, we propose a method for retinal layer segmentation and quantification of uncertainty based on Bayesian deep learning. Our method not only performs end-to-end segmentation of retinal layers, but also gives the pixel wise uncertainty measure of the segmentation output. The generated uncertainty map can be used to identify erroneously segmented image regions which is useful in downstream analysis. We have validated our method on a dataset of 1487 images obtained from 15 …
Optical Coherence Tomography (OCT) is one of the most emerging imaging modalities that has been used widely in the field of biomedical imaging. From its emergence in 1990's, plenty of hardware and software improvements have been made. Its applications range from ophthalmology to dermatology to coronary imaging etc. Here, the focus is on applications of OCT in ophthalmology and retinal imaging. OCT is able to non-invasively produce cross-sectional volume images of the tissues which are further used for analysis of the tissue structure and its properties. Due to the underlying physics, OCT image…
As a non-invasive imaging modality, optical coherence tomography (OCT) can provide micrometer-resolution 3D images of retinal structures. Therefore it is commonly used in the diagnosis of retinal diseases associated with edema in and under the retinal layers. In this paper, a new framework is proposed for the task of fluid segmentation and detection in retinal OCT images. Based on the raw images and layers segmented by a graph-cut algorithm, a fully convolutional neural network was trained to recognize and label the fluid pixels. Random forest classification was performed on the segmented flui…
With the introduction of spectral-domain optical coherence tomography (OCT), much larger image datasets are routinely acquired compared to what was possible using the previous generation of time-domain OCT. Thus, the need for 3-D segmentation methods for processing such data is becoming increasingly important. We present a new 3D segmentation method for retinal OCT volume data, which generates an enhanced volume data by using pixel intensity, boundary position information, intensity changes on both sides of the border simultaneously, and preliminary discrete boundary points are found from all …
At the present time Optical Coherence Tomography (OCT) is among the most commonly used non-invasive imaging methods for the acquisition of large volumetric scans of human retinal tissues and vasculature. To resolve decisive information from extracted OCT volumes and to make it applicable for further diagnostic analysis, the exact identification of retinal layer thicknesses serves as an essential task be done for each patient separately. However, the manual examination of multiple OCT scans in a row is a demanding and time consuming task, which results in a lengthy qualification process and is …
