School of Biomedical Engineering, Shanghai Jiao Tong University（上海交通大学生物医学工程学院）；School of Information Science and Technology, ShanghaiTech University（上海交通大学信息科学与技术学院）；School of Biomedical Engineering and the National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERCAMRT), Shanghai Jiao Tong University（上海交通大学生物医学工程学院和先进磁共振诊断与治疗国家工程研究中心）
Quantitative magnetic resonance imaging (qMRI) provides tissue-specific parameters vital for clinical diagnosis. Although simultaneous multi-parametric qMRI (MP-qMRI) technologies enhance imaging efficiency, robustly reconstructing qMRI from highly undersampled, high-dimensional measurements remains a significant challenge. This difficulty arises primarily because current reconstruction methods that rely solely on a single prior or physics-informed model to solve the highly ill-posed inverse problem, which often leads to suboptimal results. To overcome this limitation, we propose LoREIN, a novel unsupervised and dual-prior-integrated framework for accelerated 3D MP-qMRI reconstruction. Technically, LoREIN incorporates both low-rank prior and continuity prior via low-rank representation (LRR) and implicit neural representation (INR), respectively, to enhance reconstruction fidelity. The powerful continuous representation of INR enables the estimation of optimal spatial bases within the low-rank subspace, facilitating high-fidelity reconstruction of weighted images. Simultaneously, the predicted multi-contrast weighted images provide essential structural and quantitative guidance, further enhancing the reconstruction accuracy of quantitative parameter maps. Furthermore, our work introduces a zero-shot learning paradigm with broad potential in complex spatiotemporal and high-dimensional image reconstruction tasks, further advancing the field of medical imaging.
Bilkent University（比尔肯特大学）；National Magnetic Resonance Research Center, Bilkent University（比尔肯特大学国家磁共振研究中心）
Supervised reconstruction models are characteristically trained on matched pairs of undersampled and fully-sampled data to capture an MRI prior, along with supervision regarding the imaging operator to enforce data consistency. To reduce supervision requirements, the recent deep image prior framework instead conjoins untrained MRI priors with the imaging operator during inference. Yet, canonical convolutional architectures are suboptimal in capturing long-range relationships, and priors based on randomly initialized networks may yield suboptimal performance. To address these limitations, here …
Parallel imaging is a widely-used technique to accelerate magnetic resonance imaging (MRI). However, current methods still perform poorly in reconstructing artifact-free MRI images from highly undersampled k-space data. Recently, implicit neural representation (INR) has emerged as a new deep learning paradigm for learning the internal continuity of an object. In this study, we adopted INR to parallel MRI reconstruction. The MRI image was modeled as a continuous function of spatial coordinates. This function was parameterized by a neural network and learned directly from the measured k-space it…
Automatic segmentation of brain abnormalities is challenging, as they vary considerably from one pathology to another. Current methods are supervised and require numerous annotated images for each pathology, a strenuous task. To tackle anatomical variability, Unsupervised Anomaly Detection (UAD) methods are proposed, detecting anomalies as outliers of a healthy model learned using a Variational Autoencoder (VAE). Previous work on UAD adopted a 2D approach, meaning that MRIs are processed as a collection of independent slices. Yet, it does not fully exploit the spatial information contained in …
TU Munich（慕尼黑工业大学）；Klinikum rechts der Isar（伊萨尔河右岸医院）；ETH Zurich（苏黎世联邦理工学院）；Johns Hopkins University（约翰斯·霍普金斯大学）
Brain pathologies can vary greatly in size and shape, ranging from few pixels (i.e. MS lesions) to large, space-occupying tumors. Recently proposed Autoencoder-based methods for unsupervised anomaly segmentation in brain MRI have shown promising performance, but face difficulties in modeling distributions with high fidelity, which is crucial for accurate delineation of particularly small lesions. Here, similar to these previous works, we model the distribution of healthy brain MRI to localize pathologies from erroneous reconstructions. However, to achieve improved reconstruction fidelity at hi…
Institute of Medical Technology and Intelligent Systems, Hamburg University of Technology（汉堡工业大学医学技术与智能系统研究所）；jung diagnostics GmbH（jung diagnostics 有限公司）
Purpose. Brain Magnetic Resonance Images (MRIs) are essential for the diagnosis of neurological diseases. Recently, deep learning methods for unsupervised anomaly detection (UAD) have been proposed for the analysis of brain MRI. These methods rely on healthy brain MRIs and eliminate the requirement of pixel-wise annotated data compared to supervised deep learning. While a wide range of methods for UAD have been proposed, these methods are mostly 2D and only learn from MRI slices, disregarding that brain lesions are inherently 3D and the spatial context of MRI volumes remains unexploited. Metho…
Medical Faculty Mannheim of Heidelberg University（海德堡大学曼海姆医学院）
Statistical analysis of magnetic resonance imaging (MRI) can help radiologists to detect pathologies that are otherwise likely to be missed. Deep learning (DL) has shown promise in modeling complex spatial data for brain anomaly detection. However, DL models have major deficiencies: they need large amounts of high-quality training data, are difficult to design and train and are sensitive to subtle changes in scanning protocols and hardware. Here, we show that also simple statistical methods such as voxel-wise (baseline and covariance) models and a linear projection method using spatial pattern…
Institute of Medical Technology and Intelligent Systems, Hamburg University of Technology（汉堡工业大学医疗技术与智能系统研究所）；jung diagnostics GmbH（jung diagnostics GmbH公司）；Hamburg University of Technology（汉堡工业大学）
Lesion detection in brain Magnetic Resonance Images (MRIs) remains a challenging task. MRIs are typically read and interpreted by domain experts, which is a tedious and time-consuming process. Recently, unsupervised anomaly detection (UAD) in brain MRI with deep learning has shown promising results to provide a quick, initial assessment. So far, these methods only rely on the visual appearance of healthy brain anatomy for anomaly detection. Another biomarker for abnormal brain development is the deviation between the brain age and the chronological age, which is unexplored in combination with …
Harvard Medical School（哈佛医学院）；Massachusetts General Hospital（麻省总医院）；California Institute of Technology（加州理工学院）；Massachusetts Institute of Technology（麻省理工学院）
In neuroimaging, MRI tissue properties characterize underlying neurobiology, provide quantitative biomarkers for neurological disease detection and analysis, and can be used to synthesize arbitrary MRI contrasts. Estimating tissue properties from a single scan session using a protocol available on all clinical scanners promises to reduce scan time and cost, enable quantitative analysis in routine clinical scans and provide scan-independent biomarkers of disease. However, existing tissue properties estimation methods - most often $\mathbf{T_1}$ relaxation, $\mathbf{T_2^*}$ relaxation, and proto…
Université Côte d’Azur（蔚蓝海岸大学）；Inria（法国国家信息与自动化研究所）；William Harvey Research Institute（威廉·哈维研究所）；Queen Mary University of London（伦敦玛丽女王大学）；Barts Health NHS Trust（巴茨健康国民保健信托基金）
We perform unsupervised analysis of image-derived shape and motion features extracted from 3822 cardiac 4D MRIs of the UK Biobank. First, with a feature extraction method previously published based on deep learning models, we extract from each case 9 feature values characterizing both the cardiac shape and motion. Second, a feature selection is performed to remove highly correlated feature pairs. Third, clustering is carried out using a Gaussian mixture model on the selected features. After analysis, we identify two small clusters which probably correspond to two pathological categories. Furth…
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School（哈佛医学院麻省总医院Martinos生物医学影像中心）；Massachusetts Institute of Technology（麻省理工学院）；Cornell University（康奈尔大学）；University College London（伦敦大学学院）
Probabilistic atlas priors have been commonly used to derive adaptive and robust brain MRI segmentation algorithms. Widely-used neuroimage analysis pipelines rely heavily on these techniques, which are often computationally expensive. In contrast, there has been a recent surge of approaches that leverage deep learning to implement segmentation tools that are computationally efficient at test time. However, most of these strategies rely on learning from manually annotated images. These supervised deep learning methods are therefore sensitive to the intensity profiles in the training dataset. To…
Memorial Sloan Kettering Cancer Center（纪念斯隆-凯特琳癌症中心）
Our contribution is a unified cross-modality feature disentagling approach for multi-domain image translation and multiple organ segmentation. Using CT as the labeled source domain, our approach learns to segment multi-modal (T1-weighted and T2-weighted) MRI having no labeled data. Our approach uses a variational auto-encoder (VAE) to disentangle the image content from style. The VAE constrains the style feature encoding to match a universal prior (Gaussian) that is assumed to span the styles of all the source and target modalities. The extracted image style is converted into a latent style sc…
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Johns Hopkins University（约翰斯·霍普金斯大学）；University of Maryland School of Dentistry（马里兰大学牙医学院）
Cycle reconstruction regularized adversarial training -- e.g., CycleGAN, DiscoGAN, and DualGAN -- has been widely used for image style transfer with unpaired training data. Several recent works, however, have shown that local distortions are frequent, and structural consistency cannot be guaranteed. Targeting this issue, prior works usually relied on additional segmentation or consistent feature extraction steps that are task-specific. To counter this, this work aims to learn a general add-on structural feature extractor, by explicitly enforcing the structural alignment between an input and it…
Accurate segmentation of breast lesions is a crucial step in evaluating the characteristics of tumors. However, this is a challenging task, since breast lesions have sophisticated shape, topological structure, and variation in the intensity distribution. In this paper, we evaluated the performance of three unsupervised algorithms for the task of breast Magnetic Resonance (MRI) lesion segmentation, namely, Gaussian Mixture Model clustering, K-means clustering and a marker-controlled Watershed transformation based method. All methods were applied on breast MRI slices following selection of regio…
Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院保罗·C·劳特伯生物医学成像研究中心）；Research Center for Medical AI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院医学人工智能研究中心）；Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences（中国科学院大学深圳先进技术学院）；The State University of New York, Buffalo（纽约州立大学布法罗分校）
Deep learning has achieved good success in cardiac magnetic resonance imaging (MRI) reconstruction, in which convolutional neural networks (CNNs) learn a mapping from the undersampled k-space to the fully sampled images. Although these deep learning methods can improve the reconstruction quality compared with iterative methods without requiring complex parameter selection or lengthy reconstruction time, the following issues still need to be addressed: 1) all these methods are based on big data and require a large amount of fully sampled MRI data, which is always difficult to obtain for cardiac…
Self-Supervised k-Space Regularization for Motion-Resolved Abdominal MRI Using Neural Implicit k-Space Representation
Helmholtz Center Munich（慕尼黑亥姆霍兹中心）；Technical University of Munich（慕尼黑工业大学）；Imperial College London（伦敦帝国学院）；Millenium Institute for Intelligent Healthcare Engineering（千禧智能医疗工程研究所）；Pontificia Universidad Católica de Chile（智利天主教大学）；King’s College London（伦敦国王学院）
Lesion detection in brain Magnetic Resonance Images (MRI) remains a challenging task. State-of-the-art approaches are mostly based on supervised learning making use of large annotated datasets. Human beings, on the other hand, even non-experts, can detect most abnormal lesions after seeing a handful of healthy brain images. Replicating this capability of using prior information on the appearance of healthy brain structure to detect lesions can help computers achieve human level abnormality detection, specifically reducing the need for numerous labeled examples and bettering generalization of p…
Primitive Representation Learning for Unsupervised Dynamic Contrast Enhanced MRI Reconstruction
Helmholtz Munich（亥姆霍兹慕尼黑）；Technical University of Munich（慕尼黑工业大学）；Boston Children’s Hospital（波士顿儿童医院）；Harvard Medical School（哈佛医学院）；Munich Center for Machine Learning（慕尼黑机器学习中心）；Imperial College London（伦敦帝国理工学院）；King’s College London（伦敦国王学院）
City, University of London（伦敦大学城市学院）；Imperial College（帝国理工学院）
We propose a novel unsupervised out-of-distribution detection method for medical images based on implicit fields image representations. In our approach, an auto-decoder feed-forward neural network learns the distribution of healthy images in the form of a mapping between spatial coordinates and probabilities over a proxy for tissue types. At inference time, the learnt distribution is used to retrieve, from a given test image, a restoration, i.e. an image maximally consistent with the input one but belonging to the healthy distribution. Anomalies are localized using the voxel-wise probability p…
Volumetrically Consistent Implicit Atlas Learning via Neural Diffeomorphic Flow for Placenta MRI
MIT Computer Science and Artificial Intelligence Laboratory（麻省理工学院计算机科学与人工智能实验室）；Massachusetts General Hospital, Harvard Medical School（哈佛医学院麻省总医院）；Boston Children’s Hospital, Harvard Medical School（哈佛医学院波士顿儿童医院）
University of Iceland（冰岛大学）；Landspitali - University Hospital（兰斯皮塔利大学医院）；The Icelandic Heart Association（冰岛心脏协会）；The Johns Hopkins University（约翰斯·霍普金斯大学）
Lesions that appear hyperintense in both Fluid Attenuated Inversion Recovery (FLAIR) and T2-weighted magnetic resonance images (MRIs) of the human brain are common in the brains of the elderly population and may be caused by ischemia or demyelination. Lesions are biomarkers for various neurodegenerative diseases, making accurate quantification of them important for both disease diagnosis and progression. Automatic lesion detection using supervised learning requires manually annotated images, which can often be impractical to acquire. Unsupervised lesion detection, on the other hand, does not r…
École polytechnique fédérale de Lausanne (EPFL)（洛桑联邦理工学院）；University Hospital (CHUV)（沃州大学医院）；University of Lausanne (UNIL)（洛桑大学）；Center for Biomedical Imaging (CIBM)（生物医学成像中心）
We propose a novel unsupervised deep-learning-based algorithm for dynamic magnetic resonance imaging (MRI) reconstruction. Dynamic MRI requires rapid data acquisition for the study of moving organs such as the heart. Existing reconstruction methods suffer from restrictions either in the model design or in the absence of ground-truth data, resulting in low image quality. We introduce a generalized version of the deep-image-prior approach, which optimizes the network weights to fit a sequence of sparsely acquired dynamic MRI measurements. Our method needs neither prior training nor additional da…
To deform or not: treatment-aware longitudinal registration for breast DCE-MRI during neoadjuvant chemotherapy via unsupervised keypoints detection
Radboud University Medical Centre（拉德堡德大学医学中心）；The Netherlands Cancer Institute（荷兰癌症研究所）；Macao Polytechnic University（澳门理工大学）；Maastricht University Medical Centre（马斯特里赫特大学医学中心）
Bias in Unsupervised Anomaly Detection in Brain MRI
Technical University of Munich（慕尼黑工业大学）；Helmholtz AI（亥姆霍兹人工智能研究所）；Helmholtz Center Munich（亥姆霍兹慕尼黑中心）；King’s College London（伦敦国王学院）；Klinikum Rechts der Isar（伊萨尔河畔临床教学中心）；Imperial College London（帝国理工学院）
Reutlingen University（罗伊特林根大学）；Menoufia University（梅努菲亚大学）；Karlsruhe Institute of Technology（卡尔斯鲁厄理工学院）
Reliable and accurate registration of patient-specific brain magnetic resonance imaging (MRI) scans containing pathologies is challenging due to tissue appearance changes. This paper describes our contribution to the Registration of the longitudinal brain MRI task of the Brain Tumor Sequence Registration Challenge 2022 (BraTS-Reg 2022). We developed an enhanced unsupervised learning-based method that extends the iRegNet. In particular, incorporating an unsupervised learning-based paradigm as well as several minor modifications to the network pipeline, allows the enhanced iRegNet method to achi…
Spatiotemporal implicit neural representation for unsupervised dynamic MRI reconstruction
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China（上海交通大学生物医学工程学院）；School of Information Science and Technology, ShanghaiTech University, Shanghai, China（上海科技大学信息科学与技术学院）；iHuman Institute, Shanghaitech University, Shanghai, China（上海科技大学iHuman研究所）
Otto von Guericke University Magdeburg（马格德堡奥托·冯·格里克大学）；Center for Behavioral Brain Sciences（行为脑科学研究中心）；German Center for Neurodegenerative Disease（德国神经退行性疾病研究中心）
Expert interpretation of anatomical images of the human brain is the central part of neuro-radiology. Several machine learning-based techniques have been proposed to assist in the analysis process. However, the ML models typically need to be trained to perform a specific task, e.g., brain tumour segmentation or classification. Not only do the corresponding training data require laborious manual annotations, but a wide variety of abnormalities can be present in a human brain MRI - even more than one simultaneously, which renders representation of all possible anomalies very challenging. Hence, …
Memorial Sloan Kettering Cancer Center（纪念斯隆-凯特琳癌症中心）；Indian Institute of Technology, Madras（印度理工学院马德拉斯分校）
Purpose: Lesion segmentation in medical imaging is key to evaluating treatment response. We have recently shown that reinforcement learning can be applied to radiological images for lesion localization. Furthermore, we demonstrated that reinforcement learning addresses important limitations of supervised deep learning; namely, it can eliminate the requirement for large amounts of annotated training data and can provide valuable intuition lacking in supervised approaches. However, we did not address the fundamental task of lesion/structure-of-interest segmentation. Here we introduce a method co…
Korea Advanced Institute of Science and Technology（韩国科学技术院）；Samsung Electronics（三星电子）
Anomaly detection in medical imaging is to distinguish the relevant biomarkers of diseases from those of normal tissues. Deep supervised learning methods have shown potentials in various detection tasks, but its performances would be limited in medical imaging fields where collecting annotated anomaly data is limited and labor-intensive. Therefore, unsupervised anomaly detection can be an effective tool for clinical practices, which uses only unlabeled normal images as training data. In this paper, we developed an unsupervised learning framework for pixel-wise anomaly detection in multi-contra…
Rutgers University（罗格斯大学）；New York University School of Medicine（纽约大学医学院）；NVIDIA（英伟达）；SenseBrain；Shanghai AI Laboratory（上海人工智能实验室）
Cardiac tagging magnetic resonance imaging (t-MRI) is the gold standard for regional myocardium deformation and cardiac strain estimation. However, this technique has not been widely used in clinical diagnosis, as a result of the difficulty of motion tracking encountered with t-MRI images. In this paper, we propose a novel deep learning-based fully unsupervised method for in vivo motion tracking on t-MRI images. We first estimate the motion field (INF) between any two consecutive t-MRI frames by a bi-directional generative diffeomorphic registration neural network. Using this result, we then e…
From Coarse to Continuous: Progressive Refinement Implicit Neural Representation for Motion-Robust Anisotropic MRI Reconstruction
Department of Bioengineering and Imperial-X, Imperial College London（生物工程系和Imperial-X，帝国理工学院伦敦分校）；Department of Bioengineering, Imperial College London（生物工程系，帝国理工学院伦敦分校）
Towards Label-Free Brain Tumor Segmentation: Unsupervised Learning with Multimodal MRI
Universitat Politècnica de Catalunya (UPC)（西班牙巴塞罗那理工大学）；University College Dublin (UCD)（都柏林大学）；Dublin City University (DCU)（都柏林城市大学）；Insight Research Ireland Center For Data Analytics（爱尔兰数据分析研究中心）
The Johns Hopkins University School of Medicine（约翰斯·霍普金斯大学医学院）；Sidney Kimmel Comprehensive Cancer Center（西德尼·金梅尔综合癌症中心）；The Johns Hopkins University（约翰斯·霍普金斯大学）
The evaluation and treatment of acute cerebral ischemia requires a technique that can determine the total area of tissue at risk for infarction using diagnostic magnetic resonance imaging (MRI) sequences. Typical MRI data sets consist of T1- and T2-weighted imaging (T1WI, T2WI) along with advanced MRI parameters of diffusion-weighted imaging (DWI) and perfusion weighted imaging (PWI) methods. Each of these parameters has distinct radiological-pathological meaning. For example, DWI interrogates the movement of water in the tissue and PWI gives an estimate of the blood flow, both are critical me…
Mild traumatic brain injury is a growing public health problem with an estimated incidence of over 1.7 million people annually in US. Diagnosis is based on clinical history and symptoms, and accurate, concrete measures of injury are lacking. This work aims to directly use diffusion MR images obtained within one month of trauma to detect injury, by incorporating deep learning techniques. To overcome the challenge due to limited training data, we describe each brain region using the bag of word representation, which specifies the distribution of representative patch patterns. We apply a convolut…
SGAM: Shared Gaussian Geometry with Implicit Amplitude Modeling for Scan-Specific 3D Multi-Contrast MRI Reconstruction
Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院劳特伯生物医学成像研究中心）
PISCO: Self-Supervised k-Space Regularization for Improved Neural Implicit k-Space Representations of Dynamic MRI
Helmholtz Munich（亥姆霍兹慕尼黑中心）；Technical University of Munich（慕尼黑工业大学）；Klinikum rechts der Isar（右岸医院（慕尼黑工业大学附属））；Imperial College London（帝国理工学院）；Pontificia Universidad Católica de Chile（智利天主教大学）；King’s College London（伦敦国王学院）
Enhancing Implicit Neural Representations with Image Feature Embedding for Unsupervised Cardiac Cine MRI Reconstruction
Division of Image Processing, Department of Radiology, Leiden University Medical Center（莱顿大学医学中心放射科图像处理部）；C.J. Gorter Center, Department of Radiology, Leiden University Medical Center（莱顿大学医学中心放射科C.J. 戈特中心）；Cardio Vascular Imaging Group, Department of Radiology, Leiden University Medical Center（莱顿大学医学中心放射科心血管成像组）；Philips Innovative Technologies（飞利浦创新技术公司）
Harmonizing Flows: Leveraging normalizing flows for unsupervised and source-free MRI harmonization
LIVIA；ÉTS；ILLS；McGill（麦吉尔大学）；Mila；CNRS（法国国家科学研究中心）；Université Paris-Saclay（巴黎萨克雷大学）；CentraleSupelec（中央理工学院）；CHU Sainte-Justine（圣贾斯汀大学医疗中心）；University of Montreal（蒙特利尔大学）；Murdoch Children’s Research Institute（默多克儿童研究所）；Monash University（莫纳什大学）；The University of Melbourne（墨尔本大学）；The Royal Women’s Hospital（皇家妇女医院）
Unsupervised Anomaly Detection in Brain MRI via Disentangled Anatomy Learning
School of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai, China.（自动化与智能感知学院，上海交通大学，中国）；School of Computer Science, The University of Sydney, Sydney, Australia.（计算机科学学院，悉尼大学，澳大利亚）；Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.（放射科，仁济医院，医学院，上海交通大学，中国）；Biomedical Engineering Department, Tulane University, New Orleans, USA.（生物医学工程系， Tulane 大学，美国新奥尔良）
Flow-Guided Implicit Neural Representation for Motion-Aware Dynamic MRI Reconstruction
School of Automation, Guangdong University of Technology（广东工业大学自动化学院）；Research Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究所医学人工智能研究中心）；Department of Computer Science and Engineering, The Hong Kong University of Science and Technology（香港科学与技术大学计算机科学与工程系）
Amsterdam University Medical Centers（阿姆斯特丹大学医学中心）；University of Amsterdam（阿姆斯特丹大学）；Amsterdam Cardiovascular Sciences（阿姆斯特丹心血管科学研究所）；Informatics Institute, University of Amsterdam（阿姆斯特丹大学信息学研究所）
High-resolution medical images are beneficial for analysis but their acquisition may not always be feasible. Alternatively, high-resolution images can be created from low-resolution acquisitions using conventional upsampling methods, but such methods cannot exploit high-level contextual information contained in the images. Recently, better performing deep-learning based super-resolution methods have been introduced. However, these methods are limited by their supervised character, i.e. they require high-resolution examples for training. Instead, we propose an unsupervised deep learning semanti…
University of Toronto（多伦多大学）；The Hospital for Sick Children（SickKids医院（多伦多儿童医院））；Vector Institute（向量研究所）
Modern deep unsupervised learning methods have shown great promise for detecting diseases across a variety of medical imaging modalities. While previous generative modeling approaches successfully perform anomaly detection by learning the distribution of healthy 2D image slices, they process such slices independently and ignore the fact that they are correlated, all being sampled from a 3D volume. We show that incorporating the 3D context and processing whole-body MRI volumes is beneficial to distinguishing anomalies from their benign counterparts. In our work, we introduce a multi-channel sli…
U2AD: Uncertainty-based Unsupervised Anomaly Detection Framework for Detecting T2 Hyperintensity in MRI Spinal Cord
School of Biomedical Engineering, Shanghai Jiao Tong University（上海交通大学生物医学工程学院）；Renji Hospital, School of Medicine, Shanghai Jiao Tong University（上海交通大学医学院附属仁济医院）；Ruijin Hospital, Shanghai Jiao Tong University School of Medicine（上海交通大学医学院附属瑞金医院）；National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT)（先进磁共振诊疗技术国家工程研究中心）；Med-X Research Institute, Shanghai Jiao Tong University（上海交通大学Med-X研究院）
École de Technologie Supérieure（高等技术学院）；CHU Sainte-Justine Research Center（圣茹斯特医院研究中心）；Polytechnique Montréal（蒙特利尔理工学院）
Vertebral bone segmentation from magnetic resonance (MR) images is a challenging task. Due to the inherent nature of the modality to emphasize soft tissues of the body, common thresholding algorithms are ineffective in detecting bones in MR images. On the other hand, it is relatively easier to segment bones from CT images because of the high contrast between bones and the surrounding regions. For this reason, we perform a cross-modality synthesis between MR and CT domains for simple thresholding-based segmentation of the vertebral bones. However, this implicitly assumes the availability of pai…
Amsterdam UMC（阿姆斯特丹大学医学中心）；University of Amsterdam（阿姆斯特丹大学）；MS Center Amsterdam（阿姆斯特丹多发性硬化中心）；Amsterdam Neuroscience（阿姆斯特丹神经科学研究所）；Vrije Universiteit Amsterdam（阿姆斯特丹自由大学）；Leiden University（莱顿大学）；Delft University of Technology（代尔夫特理工大学）
Machine Learning methods can learn how to reconstruct Magnetic Resonance Images and thereby accelerate acquisition, which is of paramount importance to the clinical workflow. Physics-informed networks incorporate the forward model of accelerated MRI reconstruction in the learning process. With increasing network complexity, robustness is not ensured when reconstructing data unseen during training. We aim to embed data consistency (DC) in deep networks while balancing the degree of network complexity. While doing so, we will assess whether either explicit or implicit enforcement of DC in varyin…
