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arXiv 2201.13081eess.IVcs.CV
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使用深度学习和多任务脑年龄预测在3D脑MRI中进行无监督异常检测

Unsupervised Anomaly Detection in 3D Brain MRI using Deep Learning with Multi-Task Brain Age Prediction

Institute of Medical Technology and Intelligent Systems, Hamburg University of Technology(汉堡工业大学医疗技术与智能系统研究所);jung diagnostics GmbH(jung diagnostics GmbH公司);Hamburg University of Technology(汉堡工业大学)

Marcel Bengs, Finn Behrendt, Max-Heinrich Laves, Julia Krüger, Roland Opfer, Alexander Schlaefer

摘要:

脑磁共振图像(MRI)中的病变检测仍然是一项具有挑战性的任务。MRI通常由领域专家读取和解释,这是一个繁琐且耗时的过程。最近,在大脑MRI中使用深度学习的无监督异常检测(UAD)已经显示出有希望的结果,可以提供快速的初步评估。到目前为止,这些方法仅依赖于健康大脑解剖结构的视觉外观进行异常检测。大脑发育异常的另一个生物标志物是大脑年龄与实际年龄之间的偏差,这与UAD的结合尚未探索。我们提出了在3D脑MRI中进行UAD的深度学习,并考虑了额外的年龄信息。我们分析了年龄信息在训练过程中的价值,作为一个额外的异常分数,并系统地研究了几个架构概念。基于我们的分析,我们提出了一种新的具有多任务年龄预测的UAD深度学习方法。我们使用1735名健康受试者的临床T1加权MRI和公开可用的BraTs 2019数据集进行研究。我们的新方法显著提高了UAD性能,AUC为92.60%,而使用以前的方法没有年龄信息的AUC分数为84.37%。

英文摘要:

Lesion detection in brain Magnetic Resonance Images (MRIs) remains a challenging task. MRIs are typically read and interpreted by domain experts, which is a tedious and time-consuming process. Recently, unsupervised anomaly detection (UAD) in brain MRI with deep learning has shown promising results to provide a quick, initial assessment. So far, these methods only rely on the visual appearance of healthy brain anatomy for anomaly detection. Another biomarker for abnormal brain development is the deviation between the brain age and the chronological age, which is unexplored in combination with UAD. We propose deep learning for UAD in 3D brain MRI considering additional age information. We analyze the value of age information during training, as an additional anomaly score, and systematically study several architecture concepts. Based on our analysis, we propose a novel deep learning approach for UAD with multi-task age prediction. We use clinical T1-weighted MRIs of 1735 healthy subjects and the publicly available BraTs 2019 data set for our study. Our novel approach significantly improves UAD performance with an AUC of 92.60% compared to an AUC-score of 84.37% using previous approaches without age information.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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