Dementia is a progressive condition that impairs an individual's cognitive health and daily functioning, with mild cognitive impairment (MCI) often serving as its precursor. The prediction of MCI to dementia conversion has been well studied, but previous studies have almost always focused on traditional Machine Learning (ML) based methods that require sharing sensitive clinical information to train predictive models. This study proposes a privacy-enhancing solution using Federated Learning (FL) to train predictive models for MCI to dementia conversion without sharing sensitive data, leveraging socio demographic and cognitive measures. We simulated and compared two network architectures, Peer to Peer (P2P) and client-server, to enable collaborative learning. Our results demonstrated that FL had comparable predictive performance to centralized ML, and each clinical site showed similar performance without sharing local data. Moreover, the predictive performance of FL models was superior to site specific models trained without collaboration. This work highlights that FL can eliminate the need for data sharing without compromising model efficacy.
Massachusetts General Hospital（麻省总医院）；McCance Center for Brain Health（McCance脑健康中心）
Dementia is a neurodegenerative disorder that causes cognitive decline and affects more than 50 million people worldwide. Dementia is under-diagnosed by healthcare professionals - only one in four people who suffer from dementia are diagnosed. Even when a diagnosis is made, it may not be entered as a structured International Classification of Diseases (ICD) diagnosis code in a patient's charts. Information relevant to cognitive impairment (CI) is often found within electronic health records (EHR), but manual review of clinician notes by experts is both time consuming and often prone to errors.…
Early diagnosis of dementia, particularly in the prodromal stage (i.e., mild cognitive impairment, or MCI), has become a research and clinical priority but remains challenging. Automated analysis of the drawing process has been studied as a promising means for screening prodromal and clinical dementia, providing multifaceted information encompassing features, such as drawing speed, pen posture, writing pressure, and pauses. We examined the feasibility of using these features not only for detecting prodromal and clinical dementia but also for predicting the severity of cognitive impairments ass…
Queen Mary University of London（伦敦玛丽女王大学）；Jožef Stefan Institute（约热夫·斯特凡研究所）
This paper is a submission to the Alzheimer's Dementia Recognition through Spontaneous Speech (ADReSS) challenge, which aims to develop methods that can assist in the automated prediction of severity of Alzheimer's Disease from speech data. We focus on acoustic and natural language features for cognitive impairment detection in spontaneous speech in the context of Alzheimer's Disease Diagnosis and the mini-mental state examination (MMSE) score prediction. We proposed a model that obtains unimodal decisions from different LSTMs, one for each modality of text and audio, and then combines them us…
Winterlight Labs（Winterlight实验室）；University of Toronto（多伦多大学）；Vector Institute for Artificial Intelligence（Vector人工智能研究所）；Li Ka Shing Knowledge Institute（李嘉诚知识研究院）；St Michael’s Hospital（圣迈克尔医院）；Surgical Safety Technologies Inc.（手术安全技术公司）
A significant number of studies apply acoustic and linguistic characteristics of human speech as prominent markers of dementia and depression. However, studies on discriminating depression from dementia are rare. Co-morbid depression is frequent in dementia and these clinical conditions share many overlapping symptoms, but the ability to distinguish between depression and dementia is essential as depression is often curable. In this work, we investigate the ability of clustering approaches in distinguishing between depression and dementia from human speech. We introduce a novel aggregated data…
Linguistic and Audio Embedding-Based Machine Learning for Alzheimer's Dementia and Mild Cognitive Impairment Detection: Insights from the PROCESS Challenge
Singapore University of Technology and Design（新加坡科技设计大学）；Hochschule für Musik Detmold（音乐学院Detmold）
University of Vic – Central University of Catalonia（维克大学-加泰罗尼亚中央大学）
Dementia, and specially Alzheimer s disease (AD) and Mild Cognitive Impairment (MCI) are one of the most important diseases suffered by elderly population. Music therapy is one of the most widely used non-pharmacological treatment in the field of cognitive impairments, given that music influences their mood, behavior, the decrease of anxiety, as well as facilitating reminiscence, emotional expressions and movement. In this work we present HAIDA, a multi-platform support system for Musical Therapy oriented to cognitive impairment, which includes not only therapy tools but also non-invasive biom…
Predicting Mild Cognitive Impairment Using Naturalistic Driving and Trip Destination Modeling
Department of Mechanical Engineering, Iowa State University（爱荷华州立大学机械工程系）；Institute for Transportation, Iowa State University（爱荷华州立大学交通研究所）；Department of Neurological Sciences, University of Nebraska Medical Center（内布拉斯加医学院神经科学系）
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）；Faculty of Medicine Siriraj Hospital, Mahidol University（玛希隆大学诗里拉吉医学院）；Neurocognitive Disorders & Neural Computing Research Group（神经认知障碍与神经计算研究组）
In the status quo, dementia is yet to be cured. Precise diagnosis prior to the onset of the symptoms can prevent the rapid progression of the emerging cognitive impairment. Recent progress has shown that Electroencephalography (EEG) is the promising and cost-effective test to facilitate the detection of neurocognitive disorders. However, most of the existing works have been using only resting-state EEG. The efficiencies of EEG signals from various cognitive tasks, for dementia classification, have yet to be thoroughly investigated. In this study, we designed four cognitive tasks that engage di…
A comprehensive interpretable machine learning framework for Mild Cognitive Impairment and Alzheimer's disease diagnosis
Faculty of Electrical and Computer Engineering, National Technical University of Athens（雅典国立技术大学电气与计算机工程学院）；Center for Biomedical Image Computing and Analytics, University of Pennsylvania（宾夕法尼亚大学生物医学图像计算与分析中心）
Instituto Superior Técnico, Universidade de Lisboa（里斯本大学高等技术学院）
Most machine learning classifiers give predictions for new examples accurately, yet without indicating how trustworthy predictions are. In the medical domain, this hampers their integration in decision support systems, which could be useful in the clinical practice. We use a supervised learning approach that combines Ensemble learning with Conformal Predictors to predict conversion from Mild Cognitive Impairment to Alzheimer's Disease. Our goal is to enhance the classification performance (Ensemble learning) and complement each prediction with a measure of credibility (Conformal Predictors). O…
University of Bristol（布里斯托大学）；Cookpad Ltd（Cookpad有限公司）
There is a pressing need to automatically understand the state and progression of chronic neurological diseases such as dementia. The emergence of state-of-the-art sensing platforms offers unprecedented opportunities for indirect and automatic evaluation of disease state through the lens of behavioural monitoring. This paper specifically seeks to characterise behavioural signatures of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in the \textit{early} stages of the disease. We introduce bespoke behavioural models and analyses of key symptoms and deploy these on a novel dataset o…
Dementia in the elderly has recently become the most usual cause of cognitive decline. The proliferation of dementia cases in aging societies creates a remarkable economic as well as medical problems in many communities worldwide. A recently published report by The World Health Organization (WHO) estimates that about 47 million people are suffering from dementia-related neurocognitive declines worldwide. The number of dementia cases is predicted by 2050 to triple, which requires the creation of an AI-based technology application to support interventions with early screening for subsequent ment…
Tokyo Institute of Technology（东京工业大学）；Keio University School of Medicine（庆应义塾大学医学部）
We propose a non-invasive and cost-effective method to automatically detect dementia by utilizing solely speech audio data. We extract paralinguistic features for a short speech segment and use Gated Convolutional Neural Networks (GCNN) to classify it into dementia or healthy. We evaluate our method on the Pitt Corpus and on our own dataset, the PROMPT Database. Our method yields the accuracy of 73.1% on the Pitt Corpus using an average of 114 seconds of speech data. In the PROMPT Database, our method yields the accuracy of 74.7% using 4 seconds of speech data and it improves to 80.8% when we …
Washington University School of Medicine（华盛顿大学医学院）
Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of studies that applied machine learning (ML) methods to clinical data derived from electronic health records in order to model risk for progression of AD dementia. Materials and Methods: We searched for articles published between January 1, 2010, and May 31, 2020, in PubMed, Scopus, ScienceDirect, IEEE Explore Digital Library, Association for Computing Machinery…
Alzheimer's Disease (AD) is a neurodegenerative disease that affects subjects in a broad range of severity and is assessed in clinical trials with multiple cognitive and functional instruments. As clinical trials in AD increasingly focus on earlier stages of the disease, especially Mild Cognitive Impairment (MCI), the ability to model subject outcomes across the disease spectrum is extremely important. We use unsupervised machine learning models called Conditional Restricted Boltzmann Machines (CRBMs) to create Digital Twins of AD subjects. Digital Twins are simulated clinical records that sha…
DeepTokenEEG Enhancing Mild Cognitive Impairment and Alzheimers Classification via Tokenized EEG Features
Hanoi University of Science and Technology（河内科学与技术大学）；VNU University of Engineering and Technology（越南工程与技术大学）；Central Military Hospital 108（第108中心军医院）；University of California, Irvine（加州大学尔湾分校）
RIKEN Center for Advanced Intelligence Project (AIP)（理化学研究所先进智能项目中心（AIP））
Dementia and especially Alzheimer's disease (AD) are the most common causes of cognitive decline in elderly people. A spread of the above mentioned mental health problems in aging societies is causing a significant medical and economic burden in many countries around the world. According to a recent World Health Organization (WHO) report, it is approximated that currently, worldwide, about 47 million people live with a dementia spectrum of neurocognitive disorders. This number is expected to triple by 2050, which calls for possible application of AI-based technologies to support an early scree…
Center for Advanced Technology and Education（先进技术与教育中心）；Florida International University（佛罗里达国际大学）
Multiple modalities of biomarkers have been proved to be very sensitive in assessing the progression of Alzheimer's disease (AD), and using these modalities and machine learning algorithms, several approaches have been proposed to assist in the early diagnosis of AD. Among the recent investigated state-of-the-art approaches, Gaussian discriminant analysis (GDA)-based approaches have been demonstrated to be more effective and accurate in the classification of AD, especially for delineating its prodromal stage of mild cognitive impairment (MCI). Moreover, among those binary classification invest…
Predicting Deterioration in Mild Cognitive Impairment with Survival Transformers, Extreme Gradient Boosting and Cox Proportional Hazard Modelling
Goldsmiths, University of London（伦敦大学金史密斯学院）；School of Health Sciences, The University of Manchester（曼彻斯特大学健康科学学院）；Faculty of Computer Science and Engineering, Frankfurt University of Applied Sciences（法兰克福应用科学大学计算机科学与工程学院）；Institute of Psychiatry, Psychology and Neuroscience King’s College London（伦敦国王学院精神病学、心理学与神经科学研究所）
Michigan State University（密歇根州立大学）；University of Michigan（密歇根大学）；Oregon Health & Science University（俄勒冈健康与科学大学）
Mild cognitive impairment (MCI) is a prodromal phase in the progression from normal aging to dementia, especially Alzheimers disease. Even though there is mild cognitive decline in MCI patients, they have normal overall cognition and thus is challenging to distinguish from normal aging. Using transcribed data obtained from recorded conversational interactions between participants and trained interviewers, and applying supervised learning models to these data, a recent clinical trial has shown a promising result in differentiating MCI from normal aging. However, the substantial amount of intera…
Linguistic-Based Mild Cognitive Impairment Detection Using Informative Loss
Ritchie School of Engineering and Computer Science（工程与计算机科学里奇学院）；DreamFace Technologies LLC（DreamFace科技有限责任公司）；Massachusetts General Hospital（麻省总医院）；Prince Sattam Bin Abdulaziz University（萨塔姆·本·阿卜杜勒阿齐兹王子大学）
Collecting and accessing a large amount of medical data is very time-consuming and laborious, not only because it is difficult to find specific patients but also because it is required to resolve the confidentiality of a patient's medical records. On the other hand, there are deep learning models, trained on easily collectible, large scale datasets such as Youtube or Wikipedia, offering useful representations. It could therefore be very advantageous to utilize the features from these pre-trained networks for handling a small amount of data at hand. In this work, we exploit various multi-modal …
Deep Learning Approaches with Explainable AI for Differentiating Alzheimer Disease and Mild Cognitive Impairment
School of Mathematical and Natural Sciences（数学与自然科学学院）；Arizona State University（亚利桑那州立大学）；Department of Mathematics（数学系）；Florida Gulf Coast University（佛罗里达海岸大学）；Department of Public Health（公共卫生系）；Julia Jones Matthews School of Population and Public Health（朱莉亚·琼斯·马修斯人口与公共卫生学院）；Texas Tech University Health Sciences Center（德克萨斯农工大学健康科学中心）
A Machine Learning Approach for Identifying Anatomical Biomarkers of Early Mild Cognitive Impairment
Universiti Teknologi PETRONAS（国油科技大学）；Hospital Universiti Sains Malaysia（马来西亚理科大学医院）；Universiti Sains Malaysia（马来西亚理科大学）；Ulster University（阿尔斯特大学）；University of Calgary（卡尔加里大学）；University of Bath（巴斯大学）
Northwestern University（西北大学）；University of Florida（佛罗里达大学）；Weill Cornell Medicine（威尔康奈尔医学院）；Mayo Clinic（梅奥诊所）
Objective: We develop a deep learning framework based on the pre-trained Bidirectional Encoder Representations from Transformers (BERT) model using unstructured clinical notes from electronic health records (EHRs) to predict the risk of disease progression from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Materials and Methods: We identified 3657 patients diagnosed with MCI together with their progress notes from Northwestern Medicine Enterprise Data Warehouse (NMEDW) between 2000-2020. The progress notes no later than the first MCI diagnosis were used for the prediction. We fi…
Multi-Scale Graph Theoretical Analysis of Resting-State fMRI for Classification of Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls
University of Bojnord（博季努尔德大学）；Munster Technological University（芒斯特理工大学）
Wright State University（莱特州立大学）；New York University（纽约大学）
Dementia is a group of irreversible, chronic, and progressive neurodegenerative disorders resulting in impaired memory, communication, and thought processes. In recent years, clinical research advances in brain aging have focused on the earliest clinically detectable stage of incipient dementia, commonly known as mild cognitive impairment (MCI). Currently, these disorders are diagnosed using a manual analysis of neuropsychological examinations. We measure the feasibility of using the linguistic characteristics of verbal utterances elicited during neuropsychological exams of elderly subjects to…
Unveil Multi-Picture Descriptions for Multilingual Mild Cognitive Impairment Detection via Contrastive Learning
Computer Science, University of Massachusetts, Boston, MA, USA（马萨诸塞大学计算机科学系，波士顿分校）；Computer Science, University of Massachusetts, Lowell, MA, USA（马萨诸塞大学计算机科学系，洛厄尔分校）
An explainable framework for the relationship between dementia and glucose metabolism patterns
Department of Signal Processing and Biomedical Applications, University of Granada（信号处理与生物医学应用系，格拉纳达大学）；Department of Statistics and Operations Research, University of Valencia（统计与运筹学系，瓦伦西亚大学）；Department of Communication Engineering, University of Malaga（通信工程系，马拉加大学）
PROCESS-2: A Benchmark Speech Corpus for Early Cognitive Impairment Detection
School of Computer Science, University of Sheffield（谢菲尔德大学计算机科学学院）；Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield（谢菲尔德转化神经科学研究所）
Kharkevich Institute for Information Transmission Problems（哈尔克维奇信息传输问题研究所）；Skolkovo Institute of Science and Technology（斯科尔科沃科学技术研究所）
Nowadays, a lot of scientific efforts are concentrated on the diagnosis of Alzheimer's Disease (AD) applying deep learning methods to neuroimaging data. Even for 2017, there were published more than a hundred papers dedicated to AD diagnosis, whereas only a few works considered a problem of mild cognitive impairments (MCI) conversion to the AD. However, the conversion prediction is an important problem since approximately 15% of patients with MCI converges to the AD every year. In the current work, we are focusing on the conversion prediction using brain Magnetic Resonance Imaging and clinical…
Evaluating Spoken Language as a Biomarker for Automated Screening of Cognitive Impairment
Imperial College London（帝国理工学院）；UK Dementia Research Institute（英国痴呆症研究所）；Imperial College Healthcare NHS Trust（帝国理工学院医疗保健国民保健服务信托基金）；University of Surrey（萨里大学）；University of Southern California（南加州大学）
Simon Fraser University（西蒙弗雷泽大学）；Wake Forest University（维克森林大学）；University of British Columbia（不列颠哥伦比亚大学）；Ohio State University Wexner Medical Center（俄亥俄州立大学韦克斯纳医学中心）；University of Miami Miller School of Medicine（迈阿密大学米勒医学院）；University of Nottingham（诺丁汉大学）
Background: The increasing availability of databases containing both magnetic resonance imaging (MRI) and genetic data allows researchers to utilize multimodal data to better understand the characteristics of dementia of Alzheimer's type (DAT). Objective: The goal of this study was to develop and analyze novel biomarkers that can help predict the development and progression of DAT. Methods: We used feature selection and ensemble learning classifier to develop an image/genotype-based DAT score that represents a subject's likelihood of developing DAT in the future. Three feature types were used:…
National Tsing Hua University（国立清华大学）；MOST Joint Research Center for AI Technology and All Vista Healthcare（科技部人工智能技术与全视野医疗联合研究中心）；National Health Research Institutes（国家卫生研究院）
The ability to accurately detect onset of dementia is important in the treatment of the disease. Clinically, the diagnosis of Alzheimer Disease (AD) and Mild Cognitive Impairment (MCI) patients are based on an integrated assessment of psychological tests and brain imaging such as positron emission tomography (PET) and anatomical magnetic resonance imaging (MRI). In this work using two different datasets, we propose a behavior score-embedded encoder network (BSEN) that integrates regularly adminstrated psychological tests information into the encoding procedure of representing subject's resting…
Bias and Fairness in Self-Supervised Acoustic Representations for Cognitive Impairment Detection
Zentrum für Künstliche Intelligenz (KIZ), Technische Hochschule Nürnberg（人工智能中心（KIZ），图林根技术大学纽伦堡分校）；Pattern Recognition Lab, Friedrich-Alexander Universität Erlangen-Nürnberg（模式识别实验室，弗赖堡-艾尔兰根-纽伦堡大学）；GITA Lab, University of Antioquia（GITA实验室，安蒂奎亚大学）
