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arXiv 2405.01554cs.LGcs.AIq-bio.NC
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利用静息态功能MRI时间序列的混合量子-经典算法进行认知障碍早期检测

Early-stage detection of cognitive impairment by hybrid quantum-classical algorithm using resting-state functional MRI time-series

Yonsei University(延世大学);College of Medicine, Yonsei University(延世大学医学院)

Junggu Choi, Tak Hur, Daniel K. Park, Na-Young Shin, Seung-Koo Lee, Hakbae Lee, Sanghoon Han

AI总结:

本研究提出混合量子-经典算法,结合一维卷积层与量子卷积神经网络对静息态fMRI时间序列进行分类,实现早期认知障碍检测,并验证了九个关键脑区的神经科学有效性。

摘要:

随着量子机器学习技术的近期发展,文献中已报道了多种用于疾病检测的量子机器学习算法。本研究探索了一种混合量子-经典算法在早期认知障碍患者中的应用,该算法基于认知衰退对痴呆或衰老的重要性,对从静息态功能磁共振成像中获得的感兴趣区时间序列数据进行分类。在我们的混合算法中,经典一维卷积层与量子卷积神经网络结合使用。在经典模拟中,所提出的混合算法在相似训练条件下表现出比经典卷积神经网络更高的平衡准确率。此外,在116个脑区中,共有九个脑区(左侧中央前回、右侧颞上回、左侧罗兰迪克岛盖、右侧罗兰迪克岛盖、左侧海马旁回、右侧海马、左侧额内侧回、右侧小脑脚和蚓部)被发现在分类中具有相对较高的有效性,这是基于模型性能得出的。所选九个脑区与认知衰退的关联在先前研究中已有发现,并通过基于种子点的功能连接分析得到了进一步验证。我们确认了量子卷积神经网络带来的模型性能提升,以及来自混合量子-经典模型的脑区在神经科学上的有效性。

英文摘要:

Following the recent development of quantum machine learning techniques, the literature has reported several quantum machine learning algorithms for disease detection. This study explores the application of a hybrid quantum-classical algorithm for classifying region-of-interest time-series data obtained from resting-state functional magnetic resonance imaging in patients with early-stage cognitive impairment based on the importance of cognitive decline for dementia or aging. Classical one-dimensional convolutional layers are used together with quantum convolutional neural networks in our hybrid algorithm. In the classical simulation, the proposed hybrid algorithms showed higher balanced accuracies than classical convolutional neural networks under the similar training conditions. Moreover, a total of nine brain regions (left precentral gyrus, right superior temporal gyrus, left rolandic operculum, right rolandic operculum, left parahippocampus, right hippocampus, left medial frontal gyrus, right cerebellum crus, and cerebellar vermis) among 116 brain regions were found to be relatively effective brain regions for the classification based on the model performances. The associations of the selected nine regions with cognitive decline, as found in previous studies, were additionally validated through seed-based functional connectivity analysis. We confirmed both the improvement of model performance with the quantum convolutional neural network and neuroscientific validities of brain regions from our hybrid quantum-classical model.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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