The COVID-19 pandemic has profoundly impacted billions globally. It challenges public health and healthcare systems due to its rapid spread and severe respiratory effects. An effective strategy to mitigate the COVID-19 pandemic involves integrating testing to identify infected individuals. While RT-PCR is considered the gold standard for diagnosing COVID-19, it has some limitations such as the risk of false negatives. To address this problem, this paper introduces a novel Deep Learning Diagnosis System that integrates pre-trained Deep Convolutional Neural Networks (DCNNs) within an ensemble learning framework to achieve precise identification of COVID-19 cases from Chest X-ray (CXR) images. We combine feature vectors from the final hidden layers of pre-trained DCNNs using the Choquet integral to capture interactions between different DCNNs that a linear approach cannot. We employed Sugeno-$λ$ measure theory to derive fuzzy measures for subsets of networks to enable aggregation. We utilized Differential Evolution to estimate fuzzy densities. We developed a TensorFlow-based layer for Choquet operation to facilitate efficient aggregation, due to the intricacies involved in aggregating feature vectors. Experimental results on the COVIDx dataset show that our ensemble model achieved 98\% accuracy in three-class classification and 99.50\% in binary classification, outperforming its components-DenseNet-201 (97\% for three-class, 98.75\% for binary), Inception-v3 (96.25\% for three-class, 98.50\% for binary), and Xception (94.50\% for three-class, 98\% for binary)-and surpassing many previous methods.
University of Waterloo（滑铁卢大学）；Waterloo Artificial Intelligence Institute（滑铁卢人工智能研究所）；DarwinAI Corp.（DarwinAI公司）；McMaster University（麦克马斯特大学）；Thunder Bay Regional Health Sciences Centre（桑德贝地区健康科学中心）；Northern Ontario School of Medicine（北安大略医学院）
As the COVID-19 pandemic continues to devastate globally, the use of chest X-ray (CXR) imaging as a complimentary screening strategy to RT-PCR testing continues to grow given its routine clinical use for respiratory complaint. As part of the COVID-Net open source initiative, we introduce COVID-Net CXR-2, an enhanced deep convolutional neural network design for COVID-19 detection from CXR images built using a greater quantity and diversity of patients than the original COVID-Net. To facilitate this, we also introduce a new benchmark dataset composed of 19,203 CXR images from a multinational coh…
As of June 2021, the World Health Organization (WHO) has reported 171.7 million confirmed cases including 3,698,621 deaths from COVID-19. Detecting COVID-19 and other lung diseases from Chest X-Ray (CXR) images can be very effective for emergency diagnosis and treatment as CXR is fast and cheap. The objective of this study is to develop a system capable of detecting COVID-19 along with 14 other lung diseases from CXRs in a fair and unbiased manner. The proposed system consists of a CXR image selection technique and a deep learning based model to classify 15 diseases including COVID-19. The pro…
University of Waterloo（滑铁卢大学）；Waterloo AI Institute（滑铁卢人工智能研究院）；DarwinAI Corp.（达尔文人工智能公司）
After more than two years since the beginning of the COVID-19 pandemic, the pressure of this crisis continues to devastate globally. The use of chest X-ray (CXR) imaging as a complementary screening strategy to RT-PCR testing is not only prevailing but has greatly increased due to its routine clinical use for respiratory complaints. Thus far, many visual perception models have been proposed for COVID-19 screening based on CXR imaging. Nevertheless, the accuracy and the generalization capacity of these models are very much dependent on the diversity and the size of the dataset they were trained…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）
Under the global pandemic of COVID-19, the use of artificial intelligence to analyze chest X-ray (CXR) image for COVID-19 diagnosis and patient triage is becoming important. Unfortunately, due to the emergent nature of the COVID-19 pandemic, a systematic collection of the CXR data set for deep neural network training is difficult. To address this problem, here we propose a patch-based convolutional neural network approach with a relatively small number of trainable parameters for COVID-19 diagnosis. The proposed method is inspired by our statistical analysis of the potential imaging biomarkers…
University of Michigan（密歇根大学）；Henry Ford Health System（亨利·福特医疗系统）；Molecular Medicine Institute（分子医学研究所）
CXR-Net is a two-module Artificial Intelligence pipeline for the quick detection of SARS-CoV-2 from chest X-rays (CXRs). Module 1 was trained on a public dataset of 6395 CXRs with radiologist annotated lung contours to generate masks of the lungs that overlap the heart and large vasa. Module 2 is a hybrid convnet in which the first convolutional layer with learned coefficients is replaced by a layer with fixed coefficients provided by the Wavelet Scattering Transform (WST). Module 2 takes as inputs the patients CXRs and corresponding lung masks calculated by Module 1, and produces as outputs a…
National Center for Biotechnology Information (NCBI)（美国国家生物技术信息中心）；National Library of Medicine (NLM)（美国国家医学图书馆）；National Institutes of Health (NIH)（美国国立卫生研究院）；Weill Cornell Medicine（威尔康奈尔医学院）；University of Texas at Arlington（德克萨斯大学阿灵顿分校）
The latest threat to global health is the COVID-19 outbreak. Although there exist large datasets of chest X-rays (CXR) and computed tomography (CT) scans, few COVID-19 image collections are currently available due to patient privacy. At the same time, there is a rapid growth of COVID-19-relevant articles in the biomedical literature. Here, we present COVID-19-CT-CXR, a public database of COVID-19 CXR and CT images, which are automatically extracted from COVID-19-relevant articles from the PubMed Central Open Access (PMC-OA) Subset. We extracted figures, associated captions, and relevant figure…
Manchester Metropolitan University（曼彻斯特城市大学）；Brunel University（布鲁内尔大学）；Whiston Hospital（惠斯顿医院）；St Helens and Knowsley Teaching Hospitals NHS Trust（圣海伦斯和诺斯利教学医院国民保健服务信托）；University of Sheffield（谢菲尔德大学）
Accurate and rapid detection of COVID-19 pneumonia is crucial for optimal patient treatment. Chest X-Ray (CXR) is the first line imaging test for COVID-19 pneumonia diagnosis as it is fast, cheap and easily accessible. Inspired by the success of deep learning (DL) in computer vision, many DL-models have been proposed to detect COVID-19 pneumonia using CXR images. Unfortunately, these deep classifiers lack the transparency in interpreting findings, which may limit their applications in clinical practice. The existing commonly used visual explanation methods are either too noisy or imprecise, wi…
University of Waterloo（滑铁卢大学）；DarwinAI Corp.（DarwinAI公司）；Niagara Health（尼亚加拉医疗）；McMaster University（麦克马斯特大学）；Thunder Bay Regional Health Sciences Centre（桑德贝地区健康科学中心）；Northern Ontario School of Medicine（北部安大略医学院）
The world is still struggling in controlling and containing the spread of the COVID-19 pandemic caused by the SARS-CoV-2 virus. The medical conditions associated with SARS-CoV-2 infections have resulted in a surge in the number of patients at clinics and hospitals, leading to a significantly increased strain on healthcare resources. As such, an important part of managing and handling patients with SARS-CoV-2 infections within the clinical workflow is severity assessment, which is often conducted with the use of chest x-ray (CXR) images. In this work, we introduce COVID-Net CXR-S, a convolution…
Korea Advanced Institute of Science and Technology（韩国科学技术院）；Asan Medical Center（峨山医院）；University of Ulsan College of Medicine（蔚山大学医学院）；College of Medicine, Yeungnam University（岭南大学医学院）；School of Medicine, Kyungpook National University（庆北国立大学医学院）
Under the global COVID-19 crisis, developing robust diagnosis algorithm for COVID-19 using CXR is hampered by the lack of the well-curated COVID-19 data set, although CXR data with other disease are abundant. This situation is suitable for vision transformer architecture that can exploit the abundant unlabeled data using pre-training. However, the direct use of existing vision transformer that uses the corpus generated by the ResNet is not optimal for correct feature embedding. To mitigate this problem, we propose a novel vision Transformer by using the low-level CXR feature corpus that are ob…
University of Turin（都灵大学）；Azienda Ospedaliera Città della Salute e della Scienza（健康与科学城医院）
The possibility to use widespread and simple chest X-ray (CXR) imaging for early screening of COVID-19 patients is attracting much interest from both the clinical and the AI community. In this study we provide insights and also raise warnings on what is reasonable to expect by applying deep-learning to COVID classification of CXR images. We provide a methodological guide and critical reading of an extensive set of statistical results that can be obtained using currently available datasets. In particular, we take the challenge posed by current small size COVID data and show how significant can …
Qatar University（卡塔尔大学）；Universiti Kebangsaan Malaysia（马来西亚国民大学）
Novel Coronavirus disease (COVID-19) is an extremely contagious and quickly spreading Coronavirus infestation. Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), which outbreak in 2002 and 2011, and the current COVID-19 pandemic are all from the same family of coronavirus. This work aims to classify COVID-19, SARS, and MERS chest X-ray (CXR) images using deep Convolutional Neural Networks (CNNs). A unique database was created, so-called QU-COVID-family, consisting of 423 COVID-19, 144 MERS, and 134 SARS CXR images. Besides, a robust COVID-19 recognition syste…
In this work, we estimate the severity of pneumonia in COVID-19 patients and conduct a longitudinal study of disease progression. To achieve this goal, we developed a deep learning model for simultaneous detection and segmentation of pneumonia in chest Xray (CXR) images and generalized to COVID-19 pneumonia. The segmentations were utilized to calculate a "Pneumonia Ratio" which indicates the disease severity. The measurement of disease severity enables to build a disease extent profile over time for hospitalized patients. To validate the model relevance to the patient monitoring task, we devel…
Rutgers University（罗格斯大学）；Rutgers Cancer Institute of New Jersey（新泽西罗格斯癌症研究所）；The University of British Columbia（不列颠哥伦比亚大学）
The role of chest X-ray (CXR) imaging, due to being more cost-effective, widely available, and having a faster acquisition time compared to CT, has evolved during the COVID-19 pandemic. To improve the diagnostic performance of CXR imaging a growing number of studies have investigated whether supervised deep learning methods can provide additional support. However, supervised methods rely on a large number of labeled radiology images, which is a time-consuming and complex procedure requiring expert clinician input. Due to the relative scarcity of COVID-19 patient data and the costly labeling pr…
Shiraz University（设拉子大学）；Lancaster University（兰卡斯特大学）；Tehran University of Medical Sciences（德黑兰医科大学）；Bushehr University of Medical Sciences（布什尔医科大学）
The rapid outbreak of COVID-19 threatens humans life all around the world. Due to insufficient diagnostic infrastructures, developing an accurate, efficient, inexpensive, and quick diagnostic tool is of great importance. As chest radiography, such as chest X-ray (CXR) and CT computed tomography (CT), is a possible way for screening COVID-19, developing an automatic image classification tool is immensely helpful for detecting the patients with COVID-19. To date, researchers have proposed several different screening methods; however, none of them could achieve a reliable and highly sensitive per…
Indian Institute of Information Technology, Sri City, Chittoor（印度信息技术学院，斯里城，奇图尔）；Indian Institute of Information Technology, Allahabad（印度信息技术学院，阿拉哈巴德）
Covid-19 global pandemic continues to devastate health care systems across the world. At present, the Covid-19 testing is costly and time-consuming. Chest X-Ray (CXR) testing can be a fast, scalable, and non-invasive method. The existing methods suffer due to the limited CXR samples available from Covid-19. Thus, inspired by the limitations of the open-source work in this field, we propose attention guided contrastive CNN architecture (AC-CovidNet) for Covid-19 detection in CXR images. The proposed method learns the robust and discriminative features with the help of contrastive loss. Moreover…
University College London（伦敦大学学院）；King’s College London（伦敦国王学院）；Royal Free London NHS Foundation Trust（伦敦皇家自由NHS基金会信托）
During the COVID-19 pandemic, the sheer volume of imaging performed in an emergency setting for COVID-19 diagnosis has resulted in a wide variability of clinical CXR acquisitions. This variation is seen in the CXR projections used, image annotations added and in the inspiratory effort and degree of rotation of clinical images. The image analysis community has attempted to ease the burden on overstretched radiology departments during the pandemic by developing automated COVID-19 diagnostic algorithms, the input for which has been CXR imaging. Large publicly available CXR datasets have been leve…
Technische Hochschule Ulm - Ulm University of Applied Sciences（乌尔姆应用技术大学）；Universitätsklinikum Ulm - Ulm University Medical Center（乌尔姆大学医学中心）
Since the beginning of the COVID-19 pandemic, researchers have developed deep learning models to classify COVID-19 induced pneumonia. As with many medical imaging tasks, the quality and quantity of the available data is often limited. In this work we train a deep learning model on publicly available COVID-19 image data and evaluate the model on local hospital chest X-ray data. The data has been reviewed and labeled by two radiologists to ensure a high quality estimation of the generalization capabilities of the model. Furthermore, we are using a Generative Adversarial Network to generate synth…
During the COVID-19 pandemic, there has been an emerging need for rapid, dedicated, and point-of-care COVID-19 patient disposition techniques to optimize resource utilization and clinical workflow. In view of this need, we present COVID-MobileXpert: a lightweight deep neural network (DNN) based mobile app that can use chest X-ray (CXR) for COVID-19 case screening and radiological trajectory prediction. We design and implement a novel three-player knowledge transfer and distillation (KTD) framework including a pre-trained attending physician (AP) network that extracts CXR imaging features from …
University of New South Wales（新南威尔士大学）；The Commonwealth Scientific and Industrial Research Organisation (CSIRO)（联邦科学与工业研究组织（CSIRO））
Coronavirus Disease 2019 (COVID-19) has spread globally and become a health crisis faced by humanity since first reported. Radiology imaging technologies such as computer tomography (CT) and chest X-ray imaging (CXR) are effective tools for diagnosing COVID-19. However, in CT and CXR images, the infected area occupies only a small part of the image. Some common deep learning methods that integrate large-scale receptive fields may cause the loss of image detail, resulting in the omission of the region of interest (ROI) in COVID-19 images and are therefore not suitable for further processing. To…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）；Kim Jaechul Graduate School of AI（金在彻人工智能研究生院）
Federated learning, which shares the weights of the neural network across clients, is gaining attention in the healthcare sector as it enables training on a large corpus of decentralized data while maintaining data privacy. For example, this enables neural network training for COVID-19 diagnosis on chest X-ray (CXR) images without collecting patient CXR data across multiple hospitals. Unfortunately, the exchange of the weights quickly consumes the network bandwidth if highly expressive network architecture is employed. So-called split learning partially solves this problem by dividing a neural…
Qatar University（卡塔尔大学）；North South University（北南大学）；University of South Carolina（南卡罗来纳大学）；Hamad General Hospital（哈马德综合医院）；AFG College with the University of Aberdeen（阿伯丁大学AFG学院）
Fast and accurate detection of the disease can significantly help in reducing the strain on the healthcare facility of any country to reduce the mortality during any pandemic. The goal of this work is to create a multimodal system using a novel machine learning framework that uses both Chest X-ray (CXR) images and clinical data to predict severity in COVID-19 patients. In addition, the study presents a nomogram-based scoring technique for predicting the likelihood of death in high-risk patients. This study uses 25 biomarkers and CXR images in predicting the risk in 930 COVID-19 patients admitt…
Perelman School of Medicine, University of Pennsylvania（宾夕法尼亚大学佩雷尔曼医学院）；Siemens Healthineers（西门子医疗）
Purpose: To leverage volumetric quantification of airspace disease (AD) derived from a superior modality (CT) serving as ground truth, projected onto digitally reconstructed radiographs (DRRs) to: 1) train a convolutional neural network to quantify airspace disease on paired CXRs; and 2) compare the DRR-trained CNN to expert human readers in the CXR evaluation of patients with confirmed COVID-19. Materials and Methods: We retrospectively selected a cohort of 86 COVID-19 patients (with positive RT-PCR), from March-May 2020 at a tertiary hospital in the northeastern USA, who underwent chest CT a…
School of Computing and Information Technology, University of Wollongong（卧龙岗大学计算与信息技术学院）
The Coronavirus Disease 2019 (COVID-19) is affecting increasingly large number of people worldwide, posing significant stress to the health care systems. Early and accurate diagnosis of COVID-19 is critical in screening of infected patients and breaking the person-to-person transmission. Chest X-ray (CXR) based computer-aided diagnosis of COVID-19 using deep learning becomes a promising solution to this end. However, the diverse and various radiographic features of COVID-19 make it challenging, especially when considering each CXR scan typically only generates one single image. Data scarcity i…
University of Waterloo（滑铁卢大学）；Waterloo Artificial Intelligence Institute（滑铁卢人工智能研究所）；DarwinAI Corp.（达尔文人工智能公司）
The COVID-19 pandemic continues to have a devastating effect on the health and well-being of the global population. A critical step in the fight against COVID-19 is effective screening of infected patients, with one of the key screening approaches being radiology examination using chest radiography. Motivated by this and inspired by the open source efforts of the research community, in this study we introduce COVID-Net, a deep convolutional neural network design tailored for the detection of COVID-19 cases from chest X-ray (CXR) images that is open source and available to the general public. T…
Problem: Detecting COVID-19 from chest X-Ray (CXR) images has become one of the fastest and easiest methods for detecting COVID-19. However, the existing methods usually use supervised transfer learning from natural images as a pretraining process. These methods do not consider the unique features of COVID-19 and the similar features between COVID-19 and other pneumonia. Aim: In this paper, we want to design a novel high-accuracy COVID-19 detection method that uses CXR images, which can consider the unique features of COVID-19 and the similar features between COVID-19 and other pneumonia. Meth…
OSegNet: Operational Segmentation Network for COVID-19 Detection using Chest X-ray Images
Faculty of Information Technology and Communication Sciences, Tampere University（坦佩雷大学信息技术与传播科学学院）；Department of Electrical Engineering, Qatar University（卡塔尔大学电气工程学院）
COVID-19 Infection Map Generation and Detection from Chest X-Ray Images
Tampere University（坦佩雷大学）；Qatar University（卡塔尔大学）；Reem Medical Center（里姆医疗中心）；Hamad Medical Corporation Hospital（哈马德医疗公司医院）；Weill Cornell Medicine - Qatar（威尔康奈尔医学院卡塔尔分校）
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）；Asan Medical Center, University of Ulsan College of Medicine（蔚山大学医学院峨山医学中心）；College of Medicine, Yeungnam University（岭南大学医学院）；School of Medicine, Kyungpook National University（庆北国立大学医学院）
Developing a robust algorithm to diagnose and quantify the severity of COVID-19 using Chest X-ray (CXR) requires a large number of well-curated COVID-19 datasets, which is difficult to collect under the global COVID-19 pandemic. On the other hand, CXR data with other findings are abundant. This situation is ideally suited for the Vision Transformer (ViT) architecture, where a lot of unlabeled data can be used through structural modeling by the self-attention mechanism. However, the use of existing ViT is not optimal, since feature embedding through direct patch flattening or ResNet backbone in…
Hangzhou Dianzi University（杭州电子科技大学）；Communication University of Zhejiang（浙江传媒学院）；University of North Carolina at Chapel Hill（北卡罗来纳大学教堂山分校）；Shanghai Jiao Tong University（上海交通大学）
Coronavirus disease 2019 (COVID-19) is one of the most destructive pandemic after millennium, forcing the world to tackle a health crisis. Automated lung infections classification using chest X-ray (CXR) images could strengthen diagnostic capability when handling COVID-19. However, classifying COVID-19 from pneumonia cases using CXR image is a difficult task because of shared spatial characteristics, high feature variation and contrast diversity between cases. Moreover, massive data collection is impractical for a newly emerged disease, which limited the performance of data thirsty deep learni…
Fraunhofer FIT（弗劳恩霍夫应用信息技术研究所）；RWTH Aachen University（亚琛工业大学）；German National Library of Medicine（德国国家医学图书馆）；University of Cologne（科隆大学）；Vrije Universiteit Amsterdam（阿姆斯特丹自由大学）
Amid the coronavirus disease(COVID-19) pandemic, humanity experiences a rapid increase in infection numbers across the world. Challenge hospitals are faced with, in the fight against the virus, is the effective screening of incoming patients. One methodology is the assessment of chest radiography(CXR) images, which usually requires expert radiologist's knowledge. In this paper, we propose an explainable deep neural networks(DNN)-based method for automatic detection of COVID-19 symptoms from CXR images, which we call DeepCOVIDExplainer. We used 15,959 CXR images of 15,854 patients, covering nor…
Purpose: Considering several patients screened due to COVID-19 pandemic, computer-aided detection has strong potential in assisting clinical workflow efficiency and reducing the incidence of infections among radiologists and healthcare providers. Since many confirmed COVID-19 cases present radiological findings of pneumonia, radiologic examinations can be useful for fast detection. Therefore, chest radiography can be used to fast screen COVID-19 during the patient triage, thereby determining the priority of patient's care to help saturated medical facilities in a pandemic situation. Methods: I…
Universidade Estadual de Maringá（马里兰州立大学）；Instituto Federal do Paraná（巴拉那联邦学院）；Universidade Tecnológica Federal do Paraná（巴拉那联邦理工大学）；Universidade Federal do Paraná（巴拉那联邦大学）；Università Degli Studi di Padova（帕多瓦大学）；Universidade Federal de Pernambuco（伯南布哥联邦大学）
COVID-19 frequently provokes pneumonia, which can be diagnosed using imaging exams. Chest X-ray (CXR) is often useful because it is cheap, fast, widespread, and uses less radiation. Here, we demonstrate the impact of lung segmentation in COVID-19 identification using CXR images and evaluate which contents of the image influenced the most. Semantic segmentation was performed using a U-Net CNN architecture, and the classification using three CNN architectures (VGG, ResNet, and Inception). Explainable Artificial Intelligence techniques were employed to estimate the impact of segmentation. A three…
Taiwan AI Labs（台湾人工智能实验室）；National Taiwan University Hospital（国立台湾大学医学院附设医院）；Taipei Medical University Hospital（台北医学大学附设医院）；National Health Insurance Administration, Ministry of Health and Welfare（卫生福利部中央健康保险署）；Centers for Disease Control, Ministry of Health and Welfare（卫生福利部疾病管制署）；Taiwan Executive Yuan（台湾行政院）；National Taiwan University College of Medicine（国立台湾大学医学院）
We introduce a comprehensive screening platform for the COVID-19 (a.k.a., SARS-CoV-2) pneumonia. The proposed AI-based system works on chest x-ray (CXR) images to predict whether a patient is infected with the COVID-19 disease. Although the recent international joint effort on making the availability of all sorts of open data, the public collection of CXR images is still relatively small for reliably training a deep neural network (DNN) to carry out COVID-19 prediction. To better address such inefficiency, we design a cascaded learning strategy to improve both the sensitivity and the specifici…
Kobe University Graduate School of Medicine（神户大学医学院）；Kyoto University Graduate School of Medicine（京都大学医学院）
Purpose: This study aimed to develop and validate computer-aided diagnosis (CXDx) system for classification between COVID-19 pneumonia, non-COVID-19 pneumonia, and the healthy on chest X-ray (CXR) images. Materials and Methods: From two public datasets, 1248 CXR images were obtained, which included 215, 533, and 500 CXR images of COVID-19 pneumonia patients, non-COVID-19 pneumonia patients, and the healthy samples. The proposed CADx system utilized VGG16 as a pre-trained model and combination of conventional method and mixup as data augmentation methods. Other types of pre-trained models were …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Imaging tests such as chest X-ray (CXR) and computed tomography (CT) can provide useful information to clinical staff for facilitating a diagnosis of COVID-19 in a more efficient and comprehensive manner. As a breakthrough of artificial intelligence (AI), deep learning has been applied to perform COVID-19 infection region segmentation and disease classification by analyzing CXR and CT data. However, prediction uncertainty of deep learning models for these tasks, which is very important to s…
São Paulo State University (UNESP)（圣保罗州立大学（UNESP））
COVID-19 quickly became a global pandemic after only four months of its first detection. It is crucial to detect this disease as soon as possible to decrease its spread. The use of chest X-ray (CXR) images became an effective screening strategy, complementary to the reverse transcription-polymerase chain reaction (RT-PCR). Convolutional neural networks (CNNs) are often used for automatic image classification and they can be very useful in CXR diagnostics. In this paper, 21 different CNN architectures are tested and compared in the task of identifying COVID-19 in CXR images. They were applied t…
Korea Advanced Institute of Science and Technology（韩国科学技术院）；Asan Medical Center（峨山医院）；University of Ulsan College of Medicine（蔚山大学医学院）；College of Medicine, Chungnam National Univerity（忠南国立大学医学院）；College of Medicine, Yeungnam University（岭南大学医学院）；School of Medicine, Kyungpook National University（庆北国立大学医学院）
Under the global pandemic of COVID-19, building an automated framework that quantifies the severity of COVID-19 and localizes the relevant lesion on chest X-ray images has become increasingly important. Although pixel-level lesion severity labels, e.g. lesion segmentation, can be the most excellent target to build a robust model, collecting enough data with such labels is difficult due to time and labor-intensive annotation tasks. Instead, array-based severity labeling that assigns integer scores on six subdivisions of lungs can be an alternative choice enabling the quick labeling. Several gro…
Rutgers University（罗格斯大学）；Rutgers New Jersey Medical School（罗格斯新泽西医学院）；Rutgers Cancer Institute of New Jersey（罗格斯新泽西癌症研究所）；Rutgers Robert Wood Johnson Medical School（罗格斯罗伯特·伍德·约翰逊医学院）
Recently, the outbreak of the novel Coronavirus disease 2019 (COVID-19) pandemic has seriously endangered human health and life. Due to limited availability of test kits, the need for auxiliary diagnostic approach has increased. Recent research has shown radiography of COVID-19 patient, such as CT and X-ray, contains salient information about the COVID-19 virus and could be used as an alternative diagnosis method. Chest X-ray (CXR) due to its faster imaging time, wide availability, low cost and portability gains much attention and becomes very promising. Computational methods with high accurac…
Beijing University of Posts and Telecommunications（北京邮电大学）
The COVID-19 epidemic has become a major safety and health threat worldwide. Imaging diagnosis is one of the most effective ways to screen COVID-19. This project utilizes several open-source or public datasets to present an open-source dataset of COVID-19 CXRs, named COVID-19-CXR-Dataset, and introduces a deep convolutional neural network model. The model validates on 740 test images and achieves 87.3% accuracy, 89.67 % precision, and 84.46% recall, and correctly classifies 98 out of 100 COVID-19 x-ray images in test set with more than 81% prediction probability under the condition of 95% conf…
Reliable COVID-19 Detection Using Chest X-ray Images
Faculty of Information Technology and Communication Sciences, Tampere University（坦佩雷大学信息技术与通信科学学院）；Department of Electrical Engineering, Qatar University（卡塔尔大学电气工程学院）
Christian Brothers University（基督教兄弟大学）；University of Dayton（代顿大学）
With a Coronavirus disease (COVID-19) case count exceeding 10 million worldwide, there is an increased need for a diagnostic capability. The main variables in increasing diagnostic capability are reduced cost, turnaround or diagnosis time, and upfront equipment cost and accessibility. Two candidates for machine learning COVID-19 diagnosis are Computed Tomography (CT) scans and plain chest X-rays. While CT scans score higher in sensitivity, they have a higher cost, maintenance requirement, and turnaround time as compared to plain chest X-rays. The use of portable chest X-radiograph (CXR) is rec…
University of Dhaka（达卡大学）；Qatar University（卡塔尔大学）；Qatar Foundation（卡塔尔基金会）；Universiti Kebangsaan Malaysia（马来西亚国民大学）；College of Medicine（医学院）；University of Engineering and Technology, Peshawar（白沙瓦工程技术大学）
The use of computer-aided diagnosis in the reliable and fast detection of coronavirus disease (COVID-19) has become a necessity to prevent the spread of the virus during the pandemic to ease the burden on the medical infrastructure. Chest X-ray (CXR) imaging has several advantages over other imaging techniques as it is cheap, easily accessible, fast and portable. This paper explores the effect of various popular image enhancement techniques and states the effect of each of them on the detection performance. We have compiled the largest X-ray dataset called COVQU-20, consisting of 18,479 normal…
Minia University（米尼亚大学）；Nahda University in Beni-Suef（贝尼苏韦夫复兴大学）；American University in the Emirates（阿联酋美国大学）
Despite the great efforts to find an effective way for COVID-19 prediction, the virus nature and mutation represent a critical challenge to diagnose the covered cases. However, developing a model to predict COVID-19 via Chest X-Ray (CXR) images with accurate performance is necessary to help in early diagnosis. In this paper, a hybrid quantum-classical convolutional Neural Networks (HQCNN) model used the random quantum circuits (RQCs) as a base to detect COVID-19 patients with CXR images. A collection of 6952 CXR images, including 1161 COVID-19, 1575 normal, and 5216 pneumonia images, were used…
Qatar University（卡塔尔大学）；Bangladesh University of Engineering and Technology（孟加拉国工程技术大学）；Reem Medical Center（Reem医疗中心）；Hamad General Hospital（哈马德综合医院）；Weill Cornell Medicine - Qatar（威尔康奈尔医学院卡塔尔分校）
Coronavirus disease 2019 (COVID-19) has been the main agenda of the whole world, since it came into sight in December 2019 as it has significantly affected the world economy and healthcare system. Given the effects of COVID-19 on pulmonary tissues, chest radiographic imaging has become a necessity for screening and monitoring the disease. Numerous studies have proposed Deep Learning approaches for the automatic diagnosis of COVID-19. Although these methods achieved astonishing performance in detection, they have used limited chest X-ray (CXR) repositories for evaluation, usually with a few hun…
International Institute of Information Technology, Bangalore（班加罗尔国际信息技术学院）；Infineon Technologies AG（英飞凌科技股份公司）
Background and Objective:Currently, the whole world is facing a pandemic disease, novel Coronavirus also known as COVID-19, which spread in more than 200 countries with around 3.3 million active cases and 4.4 lakh deaths approximately. Due to rapid increase in number of cases and limited supply of testing kits, availability of alternative diagnostic method is necessary for containing the spread of COVID-19 cases at an early stage and reducing the death count. For making available an alternative diagnostic method, we proposed a deep neural network based diagnostic method which can be easily int…
Multi-Scale Feature Fusion using Parallel-Attention Block for COVID-19 Chest X-ray Diagnosis
Rutgers Cancer Institute of New Jersey（罗格斯新泽西癌症研究所）；Rutgers Robert Wood Johnson Medical School（罗格斯罗伯特·伍德·约翰逊医学院）；The University of British Columbia（不列颠哥伦比亚大学）
CONNECT Centre, Trinity College Dublin（都柏林圣三一大学CONNECT中心）；University of Sindh（信德大学）；Signy Advanced Technologies（西格尼先进技术公司）；Indian Institute of Technology, Dehli（印度理工学院德里分校）；King Faisal University（费萨尔国王大学）
The current COVID-19 pandemic has motivated the researchers to use artificial intelligence techniques for a potential alternative to reverse transcription-polymerase chain reaction (RT-PCR) due to the limited scale of testing. The chest X-ray (CXR) is one of the alternatives to achieve fast diagnosis but the unavailability of large-scale annotated data makes the clinical implementation of machine learning-based COVID detection difficult. Another issue is the usage of ImageNet pre-trained networks which does not extract reliable feature representations from medical images. In this paper, we pro…
The novel coronavirus 2019 (COVID-19) is a respiratory syndrome that resembles pneumonia. The current diagnostic procedure of COVID-19 follows reverse-transcriptase polymerase chain reaction (RT-PCR) based approach which however is less sensitive to identify the virus at the initial stage. Hence, a more robust and alternate diagnosis technique is desirable. Recently, with the release of publicly available datasets of corona positive patients comprising of computed tomography (CT) and chest X-ray (CXR) imaging; scientists, researchers and healthcare experts are contributing for faster and autom…
One of the critical tools for early detection and subsequent evaluation of the incidence of lung diseases is chest radiography. This study presents a real-world implementation of a convolutional neural network (CNN) based Carebot Covid app to detect COVID-19 from chest X-ray (CXR) images. Our proposed model takes the form of a simple and intuitive application. Used CNN can be deployed as a STOW-RS prediction endpoint for direct implementation into DICOM viewers. The results of this study show that the deep learning model based on DenseNet and ResNet architecture can detect SARS-CoV-2 from CXR …
Massachusetts General Hospital（麻省总医院）；Harvard University（哈佛大学）；MGH & BWH Center for Clinical Data Science（麻省总医院与布列根和妇女医院临床数据科学中心）；Kyungpook National University（庆北大学）；Yeungnam University College of Medicine（岭南大学医学院）；Catholic University of Daegu School of Medicine（大邱天主教大学医学院）；Keimyung University School of Medicine（启明大学医学院）
In recent years, deep learning-based image analysis methods have been widely applied in computer-aided detection, diagnosis and prognosis, and has shown its value during the public health crisis of the novel coronavirus disease 2019 (COVID-19) pandemic. Chest radiograph (CXR) has been playing a crucial role in COVID-19 patient triaging, diagnosing and monitoring, particularly in the United States. Considering the mixed and unspecific signals in CXR, an image retrieval model of CXR that provides both similar images and associated clinical information can be more clinically meaningful than a dir…
Emory School of Medicine（埃默里医学院）；MentorGraphics Indian Pvt. Ltd.（MentorGraphics印度私人有限公司）；K. N. Toosi University of Technology（K.N.托西理工大学）；EMORY Hospital（埃默里医院）
Purpose: Since the recent COVID-19 outbreak, there has been an avalanche of research papers applying deep learning based image processing to chest radiographs for detection of the disease. To test the performance of the two top models for CXR COVID-19 diagnosis on external datasets to assess model generalizability. Methods: In this paper, we present our argument regarding the efficiency and applicability of existing deep learning models for COVID-19 diagnosis. We provide results from two popular models - COVID-Net and CoroNet evaluated on three publicly available datasets and an additional ins…
Early detection of COVID-19 is key in containing the pandemic. Disease detection and evaluation based on imaging is fast and cheap and therefore plays an important role in COVID-19 handling. COVID-19 is easier to detect in chest CT, however, it is expensive, non-portable, and difficult to disinfect, making it unfit as a point-of-care (POC) modality. On the other hand, chest X-ray (CXR) and lung ultrasound (LUS) are widely used, yet, COVID-19 findings in these modalities are not always very clear. Here we train deep neural networks to significantly enhance the capability to detect, grade and mo…
The infection of respiratory coronavirus disease 2019 (COVID-19) starts with the upper respiratory tract and as the virus grows, the infection can progress to lungs and develop pneumonia. The conventional way of COVID-19 diagnosis is reverse transcription polymerase chain reaction (RT-PCR), which is less sensitive during early stages; especially if the patient is asymptomatic, which may further cause more severe pneumonia. In this context, several deep learning models have been proposed to identify pulmonary infections using publicly available chest X-ray (CXR) image datasets for early diagnos…
Seoul National University Hospital（首尔大学医院）；Massachusetts General Hospital（麻省总医院）；Kyungpook National University（庆北国立大学）；Yeungnam University College of Medicine（岭南大学医学院）；Catholic University of Daegu School of Medicine（大邱加图立大学医学院）；Keimyung University School of Medicine（启明大学医学院）
Purpose. Imaging plays an important role in assessing severity of COVID 19 pneumonia. However, semantic interpretation of chest radiography (CXR) findings does not include quantitative description of radiographic opacities. Most current AI assisted CXR image analysis framework do not quantify for regional variations of disease. To address these, we proposed a four region lung segmentation method to assist accurate quantification of COVID 19 pneumonia. Methods. A segmentation model to separate left and right lung is firstly applied, and then a carina and left hilum detection network is used, wh…
Coronavirus disease (COVID-19) is a contagious infection caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) and it has infected and killed millions of people across the globe. In the absence of specific drugs or vaccines for the treatment of COVID-19 and the limitation of prevailing diagnostic techniques, there is a requirement for some alternate automatic screening systems that can be used by the physicians to quickly identify and isolate the infected patients. A chest X-ray (CXR) image can be used as an alternative modality to detect and diagnose the COVID-19. In this stu…
The novel 2019 Coronavirus (COVID-19) infection has spread world widely and is currently a major healthcare challenge around the world. Chest Computed Tomography (CT) and X-ray images have been well recognized to be two effective techniques for clinical COVID-19 disease diagnoses. Due to faster imaging time and considerably lower cost than CT, detecting COVID-19 in chest X-ray (CXR) images is preferred for efficient diagnosis, assessment and treatment. However, considering the similarity between COVID-19 and pneumonia, CXR samples with deep features distributed near category boundaries are eas…
Lister Hill National Center for Biomedical Communications, National Library of Medicine（美国国家医学图书馆利斯特·希尔国家生物医学通信中心）；Takeda Pharmaceuticals（武田制药）；Saint Louis University（圣路易斯大学）；National Institutes of Health（美国国立卫生研究院）；Walt Whitman High School（沃尔特·惠特曼高中）
We demonstrate use of iteratively pruned deep learning model ensembles for detecting pulmonary manifestation of COVID-19 with chest X-rays. This disease is caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, also known as the novel Coronavirus (2019-nCoV). A custom convolutional neural network and a selection of ImageNet pretrained models are trained and evaluated at patient-level on publicly available CXR collections to learn modality-specific feature representations. The learned knowledge is transferred and fine-tuned to improve performance and generalizat…
National Institute of Technology Karnataka（卡纳塔克邦国立理工学院）；Kasturba Medical College and Hospital, Manipal（马尼帕尔卡斯图巴医学院及医院）；Manipal Academy of Higher Education（马尼帕尔高等教育学院）；J.S.S. Medical College, Mysore（迈索尔J.S.S.医学院）；JSS Academy of Higher Education and Research（JSS高等教育与研究学院）
The world is going through a challenging phase due to the disastrous effect caused by the COVID-19 pandemic on the healthcare system and the economy. The rate of spreading, post-COVID-19 symptoms, and the occurrence of new strands of COVID-19 have put the healthcare systems in disruption across the globe. Due to this, the task of accurately screening COVID-19 cases has become of utmost priority. Since the virus infects the respiratory system, Chest X-Ray is an imaging modality that is adopted extensively for the initial screening. We have performed a comprehensive study that uses CXR images to…
