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arXiv 2406.04576physics.opticsphysics.app-phphysics.bio-phphysics.med-ph
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用于红外多模态显微成像的超表面:相衬与明场

Metasurfaces for infrared multi-modal microscopy: phase contrast and bright field

Shaban B. Sulejman, Lukas Wesemann, Mikkaela McCormack, Jiajun Meng, James A. Hutchison, Niken Priscilla, Gawain McColl, Katrina Read, Wilson Sim, Andrey A. Suk… 展开作者

Shaban B. Sulejman, Lukas Wesemann, Mikkaela McCormack, Jiajun Meng, James A. Hutchison, Niken Priscilla, Gawain McColl, Katrina Read, Wilson Sim, Andrey A. Sukhorukov, Kenneth B. Crozier, Ann Roberts

AI总结:

本研究提出一种支持米氏共振的硅基超表面,可通过照明偏振调谐实现近红外相衬与明场多模态显微成像,经多种半透明样本实验验证了其在无标记即时检测中的应用潜力。

摘要:

不同成像模态用于提取光场携带的多样信息,其中两种重要模态为明场显微与相衬显微,可分别可视化样本的振幅与相位特征。然而,在同一相机上捕获这两种图像通常需要更换光学组件。超表面是可将这两种功能整合到单个微型器件中的超薄纳米结构。本研究展示了一种支持米氏共振的硅基超表面,可实现近红外相衬与明场多模态显微成像,且可通过改变照明偏振进行调谐。我们利用由空间光调制器合成、经半透明样本(包括秀丽隐杆线虫、未染色的人前列腺癌细胞和乳腺组织)传播引入相位变化的光场开展实验,结果证明了超表面在无标记即时检测中的应用潜力。

英文摘要:

Different imaging modalities are used to extract the diverse information carried in an optical field. Two prominent modalities include bright field and phase contrast microscopy that can visualize the amplitude and phase features of a sample, respectively. However, capturing both of these images on the same camera typically requires interchanging optical components. Metasurfaces are ultra-thin nanostructures that can merge both of these operations into a single miniaturized device. Here, a silicon-based metasurface that supports a Mie resonance is demonstrated to perform near-infrared phase contrast and bright field multi-modal microscopy that can be tuned by changing the polarization of the illumination. We performed experiments using optical fields with phase variations synthesized by a spatial light modulator and introduced by propagation through semi-transparent samples, including C. elegans, unstained human prostate cancer cells and breast tissue. The results demonstrate the potential of metasurfaces for label-free point-of-care testing.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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