An efficient dual-branch framework via implicit self-texture enhancement for arbitrary-scale histopathology image super-resolution
Digital Medical Research Center, School of Basic Medical Sciences, Fudan University（复旦大学基础医学院数字医学研究中心）；Academy for Engineering and Technology, Fudan University（复旦大学工程技术研究院）
High-quality whole-slide scanning is expensive, complex, and time-consuming, thus limiting the acquisition and utilization of high-resolution histopathology images in daily clinical work. Deep learning-based single-image super-resolution (SISR) techniques provide an effective way to solve this problem. However, the existing SISR models applied in histopathology images can only work in fixed integer scaling factors, decreasing their applicability. Though methods based on implicit neural representation (INR) have shown promising results in arbitrary-scale super-resolution (SR) of natural images, applying them directly to histopathology images is inadequate because they have unique fine-grained image textures different from natural images. Thus, we propose an Implicit Self-Texture Enhancement-based dual-branch framework (ISTE) for arbitrary-scale SR of histopathology images to address this challenge. The proposed ISTE contains a feature aggregation branch and a texture learning branch. We employ the feature aggregation branch to enhance the learning of the local details for SR images while utilizing the texture learning branch to enhance the learning of high-frequency texture details. Then, we design a two-stage texture enhancement strategy to fuse the features from the two branches to obtain the SR images. Experiments on publicly available datasets, including TMA, HistoSR, and the TCGA lung cancer datasets, demonstrate that ISTE outperforms existing fixed-scale and arbitrary-scale SR algorithms across various scaling factors. Additionally, extensive experiments have shown that the histopathology images reconstructed by the proposed ISTE are applicable to downstream pathology image analysis tasks.
University of Waterloo（滑铁卢大学）；University of Toronto（多伦多大学）；Vector Institute（矢量研究院）
Recent advances in digital pathology have led to the need for Histopathology Image Retrieval (HIR) systems that search through databases of biopsy images to find similar cases to a given query image. These HIR systems allow pathologists to effortlessly and efficiently access thousands of previously diagnosed cases in order to exploit the knowledge in the corresponding pathology reports. Since HIR systems may have to deal with millions of gigapixel images, the extraction of compact and expressive image features must be available to allow for efficient and accurate retrieval. In this paper, we p…
Shandong Normal University（山东师范大学）；Nanjing University of Science and Technology（南京理工大学）
Low-light image enhancement is a classical computer vision problem aiming to recover normal-exposure images from low-light images. However, convolutional neural networks commonly used in this field are good at sampling low-frequency local structural features in the spatial domain, which leads to unclear texture details of the reconstructed images. To alleviate this problem, we propose a novel module using the Fourier coefficients, which can recover high-quality texture details under the constraint of semantics in the frequency phase and supplement the spatial domain. In addition, we design a s…
College of Information Science and Engineering, Xinjiang University（新疆大学信息科学与工程学院）
Image super-resolution reconstruction achieves better results than traditional methods with the help of the powerful nonlinear representation ability of convolution neural network. However, some existing algorithms also have some problems, such as insufficient utilization of phased features, ignoring the importance of early phased feature fusion to improve network performance, and the inability of the network to pay more attention to high-frequency information in the reconstruction process. To solve these problems, we propose a multi-branch feature multiplexing fusion network with mixed multi-…
University of Warwick（华威大学）；Tissue Image Analytics (TIA) Centre, University of Warwick（华威大学组织图像分析中心）
The problem of recognizing various types of tissues present in multi-gigapixel histology images is an important fundamental pre-requisite for downstream analysis of the tumor microenvironment in a bottom-up analysis paradigm for computational pathology. In this paper, we propose a deep dictionary learning approach to solve the problem of tissue phenotyping in histology images. We propose deep Multi-Resolution Dictionary Learning (deepMRDL) in order to benefit from deep texture descriptors at multiple different spatial resolutions. We show the efficacy of the proposed approach through extensive…
Artifacts, blur and noise are the common distortions degrading MRI images during the acquisition process, and deep neural networks have been demonstrated to help in improving image quality. To well exploit global structural information and texture details, we propose a novel biomedical image enhancement network, named Feedback Graph Attention Convolutional Network (FB-GACN). As a key innovation, we consider the global structure of an image by building a graph network from image sub-regions that we consider to be node features, linking them non-locally according to their similarity. The propose…
Existing deep neural networks for histopathology image synthesis cannot generate image styles that align with different organs, and cannot produce accurate boundaries of clustered nuclei. To address these issues, we propose a style-guided instance-adaptive normalization (SIAN) approach to synthesize realistic color distributions and textures for histopathology images from different organs. SIAN contains four phases, semantization, stylization, instantiation, and modulation. The first two phases synthesize image semantics and styles by using semantic maps and learned image style vectors. The in…
Radboud University Medical Center（拉德堡德大学医学中心）；Institute of Experimental Immunology, University of Zurich（苏黎世大学实验免疫学研究所）；Center for Medical Image Science and Visualization, Linköping University（林雪平大学医学影像科学与可视化中心）
We propose HookNet, a semantic segmentation model for histopathology whole-slide images, which combines context and details via multiple branches of encoder-decoder convolutional neural networks. Concentricpatches at multiple resolutions with different fields of view are used to feed different branches of HookNet, and intermediate representations are combined via a hooking mechanism. We describe a framework to design and train HookNet for achieving high-resolution semantic segmentation and introduce constraints to guarantee pixel-wise alignment in feature maps during hooking. We show the advan…
University of Toronto（多伦多大学）；University of Alberta（阿尔伯塔大学）
Computational histopathology image diagnosis becomes increasingly popular and important, where images are segmented or classified for disease diagnosis by computers. While pathologists do not struggle with color variations in slides, computational solutions usually suffer from this critical issue. To address the issue of color variations in histopathology images, this study proposes two stain style transfer models, SSIM-GAN and DSCSI-GAN, based on the generative adversarial networks. By cooperating structural preservation metrics and feedback of an auxiliary diagnosis net in learning, medical-…
EvTexture: Event-driven Texture Enhancement for Video Super-Resolution
University of Science and Technology of China（中国科学技术大学）；Institute of Artificial Intelligence, Hefei Comprehensive National Science Center（合肥综合性国家科学中心人工智能研究院）
Tsinghua Shenzhen International Graduate School, Tsinghua University（清华大学深圳国际研究生院）；University College London（伦敦大学学院）
Image quality assessment (IQA) algorithm aims to quantify the human perception of image quality. Unfortunately, there is a performance drop when assessing the distortion images generated by generative adversarial network (GAN) with seemingly realistic texture. In this work, we conjecture that this maladaptation lies in the backbone of IQA models, where patch-level prediction methods use independent image patches as input to calculate their scores separately, but lack spatial relationship modeling among image patches. Therefore, we propose an Attention-based Hybrid Image Quality Assessment Netw…
The diagnosis of cancer is mainly performed by visual analysis of the pathologists, through examining the morphology of the tissue slices and the spatial arrangement of the cells. If the microscopic image of a specimen is not stained, it will look colorless and textured. Therefore, chemical staining is required to create contrast and help identify specific tissue components. During tissue preparation due to differences in chemicals, scanners, cutting thicknesses, and laboratory protocols, similar tissues are usually varied significantly in appearance. This diversity in staining, in addition to…
Among the major remaining challenges for single image super resolution (SISR) is the capacity to recover coherent images with global shapes and local details conforming to human vision system. Recent generative adversarial network (GAN) based SISR methods have yielded overall realistic SR images, however, there are always unpleasant textures accompanied with structural distortions in local regions. To target these issues, we introduce the gradient branch into the generator to preserve structural information by restoring high-resolution gradient maps in SR process. In addition, we utilize a U-n…
Histopathology relies on the analysis of microscopic tissue images to diagnose disease. A crucial part of tissue preparation is staining whereby a dye is used to make the salient tissue components more distinguishable. However, differences in laboratory protocols and scanning devices result in significant confounding appearance variation in the corresponding images. This variation increases both human error and the inter-rater variability, as well as hinders the performance of automatic or semi-automatic methods. In the present paper we introduce an unsupervised adversarial network to translat…
EvTexture++: Event-Driven Texture Enhancement for Video Super-Resolution
MOE Key Laboratory of Brain-Inspired Intelligent Perception and Cognition, University of Science and Technology of China（中国科学技术大学，脑启发智能感知与认知教育部重点实验室）；Midea Group（美的集团）
University of Science and Technology of China（中国科学技术大学）；Huawei Technologies（华为技术有限公司）；Huawei Cloud BU（华为云业务单元）
When smartphone cameras are used to take photos of digital screens, usually moire patterns result, severely degrading photo quality. In this paper, we design a wavelet-based dual-branch network (WDNet) with a spatial attention mechanism for image demoireing. Existing image restoration methods working in the RGB domain have difficulty in distinguishing moire patterns from true scene texture. Unlike these methods, our network removes moire patterns in the wavelet domain to separate the frequencies of moire patterns from the image content. The network combines dense convolution modules and dilate…
Wavelet-based Decoupling Framework for low-light Stereo Image Enhancement
Shaanxi Key Laboratory for Network Computing and Security Technology（陕西网络计算与安全技术重点实验室）；School of Computer Science and Engineering（计算机科学与工程学院）；Xi'an University of Technology（西安理工大学）
School of Mathematics, Sichuan University（四川大学数学学院）
Deep learning based methods have achieved the state-of-the-art performance in image denoising. In this paper, a deep learning based denoising method is proposed and a module called fusion block is introduced in the convolutional neural network. For this so-called Noise Fusion Convolutional Neural Network (NFCNN), there are two branches in its multi-stage architecture. One branch aims to predict the latent clean image, while the other one predicts the residual image. A fusion block is contained between every two stages by taking the predicted clean image and the predicted residual image as a pa…
TextOVSR: Text-Guided Real-World Opera Video Super-Resolution
School of Computer Science and Technology, Wuhan University of Science and Technology（武汉科技大学计算机科学与技术学院）；Hubei Province Key Laboratory of Intelligent Information Processing and Real-time Industrial System（湖北省智能信息处理与实时工业系统重点实验室）；Harbin Institute of Technology Zhengzhou Research Institute（哈尔滨工业大学郑州研究所）；Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ)（广东省人工智能与数字经济实验室（深圳））；Huawei Technologies Ltd（华为技术有限公司）
DAF-Net: A Dual-Branch Feature Decomposition Fusion Network with Domain Adaptive for Infrared and Visible Image Fusion
University of Electronic Science and Technology of China（电子科技大学）；School of Information and Communication Engineering（信息与通信工程学院）；School of Resources and Environment（资源与环境学院）
MoE Key Lab of Artificial Intelligence, Shanghai Jiao Tong University（上海交通大学人工智能教育部重点实验室）；INTSIG
Superimposing visible watermarks on images provides a powerful weapon to cope with the copyright issue. Watermark removal techniques, which can strengthen the robustness of visible watermarks in an adversarial way, have attracted increasing research interest. Modern watermark removal methods perform watermark localization and background restoration simultaneously, which could be viewed as a multi-task learning problem. However, existing approaches suffer from incomplete detected watermark and degraded texture quality of restored background. Therefore, we design a two-stage multi-task network t…
Université Paris-Saclay（巴黎萨克雷大学）；CentraleSupélec（中央理工-高等电力学院）；Inria Saclay（法国国家信息与自动化研究所萨克雷分校）；Institut Gustave Roussy（古斯塔夫·鲁西研究所）；Peter MacCallum Cancer Centre（彼得·麦卡伦癌症中心）；GZA-ZNA Hospitals（GZA-ZNA医院）；Therapanacea（Therapanacea公司）
Segmentation and accurate localization of nuclei in histopathological images is a very challenging problem, with most existing approaches adopting a supervised strategy. These methods usually rely on manual annotations that require a lot of time and effort from medical experts. In this study, we present a self-supervised approach for segmentation of nuclei for whole slide histopathology images. Our method works on the assumption that the size and texture of nuclei can determine the magnification at which a patch is extracted. We show that the identification of the magnification level for tiles…
Dual-branch Graph Feature Learning for NLOS Imaging
Zhejiang University（浙江大学）；China Mobile Research Institute（中国移动研究院）；Westlake University（西湖大学）；Shanghai Jiao Tong University（上海交通大学）；University of Science and Technology of China（中国科学技术大学）
Hazy images are often subject to color distortion, blurring, and other visible quality degradation. Some existing CNN-based methods have great performance on removing homogeneous haze, but they are not robust in non-homogeneous case. The reasons are mainly in two folds. Firstly, due to the complicated haze distribution, texture details are easy to be lost during the dehazing process. Secondly, since the training pairs are hard to be collected, training on limited data can easily lead to over-fitting problem. To tackle these two issues, we introduce a novel dehazing network using 2D discrete wa…
