Ovarian cancer remains one of the most lethal gynecological malignancies, largely due to late diagnosis and extensive heterogeneity across subtypes. Current diagnostic methods are limited in their ability to reveal underlying genomic variations essential for precision oncology. This study introduces a novel hybrid deep learning pipeline that integrates quantitative nuclear morphometry with deep convolutional image features to perform ovarian cancer subtype classification and gene mutation inference directly from Hematoxylin and Eosin (H&E) histopathological images. Using $\sim45,000$ image patches sourced from The Cancer Genome Atlas (TCGA) and public datasets, a fusion model combining a ResNet-50 Convolutional Neural Network (CNN) encoder and a Vision Transformer (ViT) was developed. This model successfully captured both local morphological texture and global tissue context. The pipeline achieved a robust overall subtype classification accuracy of $84.2\%$ (Macro AUC of $0.87 \pm 0.03$). Crucially, the model demonstrated the capacity for gene mutation inference with moderate-to-high accuracy: $AUC_{TP53} = 0.82 \pm 0.02$, $AUC_{BRCA1} = 0.76 \pm 0.04$, and $AUC_{ARID1A} = 0.73 \pm 0.05$. Feature importance analysis established direct quantitative links, revealing that nuclear solidity and eccentricity were the dominant predictors for TP53 mutation. These findings validate that quantifiable histological phenotypes encode measurable genomic signals, paving the way for cost-effective, precision histopathology in ovarian cancer triage and diagnosis.
Benchmarking Histopathology Foundation Models for Ovarian Cancer Bevacizumab Treatment Response Prediction from Whole Slide Images
Faculty of Science, University of British Columbia(不列颠哥伦比亚大学理学院);School of Biomedical Engineering, University of British Columbia(不列颠哥伦比亚大学生物医学工程学院);Department of Pathology and Laboratory Medicine, University of British Columbia(不列颠哥伦比亚大学病理学与实验医学系);Canada’s Michael Smith Genome Sciences Centre, BC Cancer Research Institute(加拿大迈克尔·史密斯基因组科学中心,BC癌症研究所)
A Comprehensive Evaluation of Histopathology Foundation Models for Ovarian Cancer Subtype Classification
University of Leeds(利兹大学);Leeds Institute of Medical Research at St James's(圣詹姆斯利兹医学研究所);Leeds Cancer Centre(利兹癌症中心);St James's University Hospital(圣詹姆斯大学医院);Leeds Teaching Hospitals NHS Trust(利兹教学医院国民保健信托基金);National Pathology Imaging Cooperative (NPIC)(国家病理影像合作组织)
Multi-Resolution Histopathology Patch Graphs for Ovarian Cancer Subtyping
Centre for Computational Imaging and Simulation Technologies in Biomedicine (CISTIB)(生物医学计算成像与模拟技术中心);School of Computing, University of Leeds(利兹大学计算机学院);Leeds Institute of Medical Research at St James’s, School of Medicine, University of Leeds(利兹大学医学院圣詹姆斯利兹医学研究所);Leeds Cancer Centre, St James’s University Hospital(圣詹姆斯大学医院利兹癌症中心)
Deep Interactive Learning-based ovarian cancer segmentation of H&E-stained whole slide images to study morphological patterns of BRCA mutation
Memorial Sloan Kettering Cancer Center(纪念斯隆凯特琳癌症中心);University of Ulsan College of Medicine(蔚山大学医学院);Asan Medical Center(峨山医学中心);Ajou University School of Medicine(亚洲大学医学院);Icahn School of Medicine at Mount Sinai(西奈山伊坎医学院)
A Morphology Focused Diffusion Probabilistic Model for Synthesis of Histopathology Images
University of British Columbia(不列颠哥伦比亚大学);Eindhoven University of Technology(埃因霍温理工大学);Massachusetts General Hospital(马萨诸塞州综合医院);Harvard Medical School(哈佛医学院);BC Cancer Agency(不列颠哥伦比亚癌症机构)
MB-DSMIL-CL-PL: Scalable Weakly Supervised Ovarian Cancer Subtype Classification and Localisation Using Contrastive and Prototype Learning with Frozen Patch Features
School of Computing Sciences, University of East Anglia(东安格利亚大学计算机科学学院);Norfolk and Norwich University Hospital(诺福克和诺里奇大学医院);University of East Anglia(东安格利亚大学)
Pan-Cancer Diagnostic Consensus Through Searching Archival Histopathology Images Using Artificial Intelligence
Huron Digital Pathology(休伦数字病理学公司);University of Waterloo(滑铁卢大学);Vector Institute(矢量研究所);McMaster University(麦克马斯特大学);University of Pittsburgh Medical Center(匹兹堡大学医学中心)
Learning latent progression states from spatial heterogeneity in uterine histopathology
Fuzhou University(福州大学);Fuzhou University Affiliated Provincial Hospital(福州大学附属省立医院);Interdisciplinary Institute for Medical Engineering, Fuzhou University(福州大学医学工程交叉研究院);Medical Optical Technology R&D Center, Research Institute of Tsinghua, Pearl River Delta(清华珠三角研究院医学光学技术研发中心);Peking University Health Science Center(北京大学医学部);Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center(北京大学医学部基础医学院第三医院);Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University(清华大学深圳国际研究生院生物医药与健康工程研究院);Tsinghua University(清华大学);Peng Cheng Laboratory(鹏城实验室);Jinfeng Laboratory(金凤实验室)
Hierarchical Prototype-based Domain Priors for Multiple Instance Learning in Multimodal Histopathology Analysis
College of Computer and Information Science, Fujian Agriculture and Forestry University(福建农林大学计算机与信息科学学院);College of Future Technology, Fujian Agriculture and Forestry University(福建农林大学未来技术学院);Digital Fujian Institute of Agricultural Big Data, Fujian Agriculture and Forestry University(福建农业大数据数字福建研究院);Department of Pathology, Clinical Oncology School of Fujian Medical University, and Fujian Cancer Hospital(福建医科大学临床肿瘤学院病理科及福建癌症医院)
Friedrich-Alexander-Universität Erlangen-Nürnberg(埃尔朗根-纽伦堡弗里德里希-亚历山大大学);Freie Universität Berlin(柏林自由大学);University of Veterinary Medicine, Vienna(维也纳兽医大学);University Medical Centre Utrecht(乌得勒支大学医学中心);Technische Hochschule Ingolstadt(因戈尔施塔特应用技术大学)
University of Technology, Ho Chi Minh City, Vietnam(越南胡志明市技术大学);Carnegie Mellon University, Pennsylvania, USA(卡内基梅隆大学);Posts and Telecommunications Institute of Technology, Ho Chi Minh City, Vietnam(越南邮电技术研究所);Purdue University, Indiana, USA(普渡大学);University of Alabama at Birmingham, Alabama, USA(阿拉巴马大学伯明翰分校)
Generalizable Hyperparameter Optimization for Federated Learning on Non-IID Cancer Images
Institute of Exact and Technological Sciences, Federal University of Viçosa - UFV, Rio Paranaíba-MG, Brazil(精确与技术科学研究所,弗拉维亚联邦大学-UFV,里奥帕拉纳伊巴-巴西);Department of Computing, Federal University of São Carlos, São Carlos-SP, Brazil(计算系,圣卡洛斯联邦大学,圣卡洛斯-巴西)
ConStruct: Structural Distillation of Foundation Models for Prototype-Based Weakly Supervised Histopathology Segmentation
Ho Chi Minh City University of Technology(胡志明市技术大学);University of Technology Sydney(悉尼技术大学);University of Houston(休斯顿大学);University of Information Technology(信息科技大学);College of Medical Science and Technology, Taipei Medical University(台北医学院医学科技学院);Department of Computer Science, Emory University(埃默里大学计算机科学系);Montefiore Medical Center, Albert Einstein College of Medicine(蒙特福伊医疗中心,阿尔伯特·爱因斯坦医学院);School of Computer Science, Carnegie Mellon University(卡内基梅隆大学计算机科学学院)
PAST: A multimodal single-cell foundation model for histopathology and spatial transcriptomics in cancer
King Abdullah University of Science and Technology (KAUST)(阿卜杜拉国王科技大学);Shanghai Academy of Artificial Intelligence for Science(上海科学智能研究院);Fudan University(复旦大学);Zhongshan Hospital, Fudan University(复旦大学附属中山医院)
A tissue and cell-level annotated H&E and PD-L1 histopathology image dataset in non-small cell lung cancer
Radboud University Medical Center(拉德堡德大学医学中心);University of Brescia(布雷西亚大学);Ospedale Sacro Cuore(圣十字医院);Provincial Hospital of Bolzano (SABES-ASDAA)(博尔扎诺省医院);University and Hospital Trust of Verona(威尼斯大学与医院信托);Karolinska University Hospital(卡罗林斯卡大学医院);Biopticka Laboratory, Ltd(Biopticka实验室)
CellPilot: A unified approach to automatic and interactive segmentation in histopathology
School of Computation and Information Technology, Technical University of Munich(慕尼黑工业大学计算与信息技术学院);Helmholtz Zentrum München - German Research Center for Environmental Health(亥姆霍兹慕尼黑中心——德国环境健康研究中心);School of Biomedical Engineering and Imaging Sciences, King’s College London(伦敦国王学院生物医学工程与影像科学学院)
Are nuclear masks all you need for improved out-of-domain generalisation? A closer look at cancer classification in histopathology
University of Oslo(奥斯陆大学);Otto-von-Guericke University Magdeburg(马格德堡奥托·冯·格里克大学);Singapore Institute of Technology(新加坡科技学院);Oslo University Hospital(奥斯陆大学医院);UiT The Arctic University of Norway(挪威北极大学)
Adaptive Multi-Scale Integration Unlocks Robust Cell Annotation in Histopathology Images
Department of Computer and Information Science, University of Pennsylvania(计算机与信息科学系,宾夕法尼亚大学);Department of Bioengineering, University of Pennsylvania(生物工程系,宾夕法尼亚大学);Department of Pathology and Laboratory Medicine, University of Pennsylvania(病理学与实验室医学系,宾夕法尼亚大学);Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania(生物统计学、流行病学与信息学系,宾夕法尼亚大学)
Faculty of Informatics and Data Science, University of Regensburg, Germany(信息学与数据科学学院,雷根萨大学);Indian Institute of Information Technology Bhopal, India(比哈尔信息学院)
Deep learning-based assessment of tumor-associated stroma for diagnosing breast cancer in histopathology images
Radboud University Medical Center(拉德堡德大学医学中心);Beth Israel Deaconess Medical Center(贝斯以色列女执事医疗中心);Harvard Medical School(哈佛医学院);National Cancer Institute(美国国家癌症研究所);The Harker School(哈克学校);Mayo Clinic(梅奥诊所)
Controllable Diffusion-Based Lesion Inpainting for Scalable Histopathology Data Augmentation
Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong(香港大学李嘉诚医学院诊断放射学系);Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong(香港大学李嘉诚医学院病理学系);Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong(香港中文大学威尔斯亲王医院解剖及细胞病理学系);Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong(香港城市大学赛马会动物医学及生命科学院传染病及公共卫生学系);CityU Veterinary Diagnostic Laboratory Co., Ltd., City University of Hong Kong(香港城市大学城市大学兽医诊断实验室有限公司)
Learning Disentangled Stain and Structural Representations for Semi-Supervised Histopathology Segmentation
University of Science, VNU-HCM(越南胡志明市科学大学);Ho Chi Minh University of Technology(胡志明技术大学);Vietnam National University(越南国家大学);Carnegie Mellon University(卡内基梅隆大学);Northwestern University(西北大学);College of Engineering & Computer Science, VinUniversity(Vin大学工程与计算机科学学院);VinUni-Illinois Smart Health Center, VinUniversity(Vin大学伊利诺伊智能健康中心)
DepViT-CAD: Deployable Vision Transformer-Based Cancer Diagnosis in Histopathology
University of Padova, Italy(意大利帕多瓦大学);Unit of Surgical Pathology and Cytopathology, Ospedale dell’Angelo, Italy(意大利奥斯佩达莱-安吉洛外科病理学与细胞病理学单位);Pathological Anatomy Unit, Padova University-Hospital, Italy(意大利帕多瓦大学医院病理学解剖单位);Department of Medicine, University of Padova, Italy(意大利帕多瓦大学医学系);Department of Integrated Diagnostics, Azienda Ospedale-Università Padova, Italy(意大利帕多瓦医院-大学整合诊断系)
Automatic and explainable grading of meningiomas from histopathology images
Technische Hochschule Ingolstadt(英戈尔施塔特工业大学);University Hospital Erlangen(埃尔朗根大学医院);University of Veterinary Medicine Vienna(维也纳兽医大学);Friedrich-Alexander-Universität Erlangen-Nürnberg(弗里德里希-亚历山大-埃尔朗根-纽伦堡大学)
Retrieval-Guided Generation for Safer Histopathology Image Captioning
Kimia Lab, Department of Artificial Intelligence \& Informatics, Mayo Clinic, Rochester, MN, USA;Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA;Lane Department of Computer Science;Electrical Engineering, West Virginia University, Morgantown, WV, USA;Department of Computer Science;Engineering, Princeton University, Princeton, NJ, USA;Department of Computer Sciences, University of Wisconsin--Madison, Madison, WI, USA