Segmentation and accurate localization of nuclei in histopathological images is a very challenging problem, with most existing approaches adopting a supervised strategy. These methods usually rely on manual annotations that require a lot of time and effort from medical experts. In this study, we present a self-supervised approach for segmentation of nuclei for whole slide histopathology images. Our method works on the assumption that the size and texture of nuclei can determine the magnification at which a patch is extracted. We show that the identification of the magnification level for tiles can generate a preliminary self-supervision signal to locate nuclei. We further show that by appropriately constraining our model it is possible to retrieve meaningful segmentation maps as an auxiliary output to the primary magnification identification task. Our experiments show that with standard post-processing, our method can outperform other unsupervised nuclei segmentation approaches and report similar performance with supervised ones on the publicly available MoNuSeg dataset. Our code and models are available online to facilitate further research.
Histology method is vital in the diagnosis and prognosis of cancers and many other diseases. For the analysis of histopathological images, we need to detect and segment all gland structures. These images are very challenging, and the task of segmentation is even challenging for specialists. Segmentation of glands determines the grade of cancer such as colon, breast, and prostate. Given that deep neural networks have achieved high performance in medical images, we propose a method based on the LinkNet network for gland segmentation. We found the effects of using different loss functions. By usi…
Accurate segmentation of medical images is essential for diagnosis and treatment of diseases. These problems are solved by highly complex models, such as deep networks (DN), requiring a large amount of labeled data for training. Thereby, many DNs possess task- or imaging modality specific architectures with a decision-making process that is often hard to explain and interpret. Here, we propose a framework that embeds existing DNs into a low-dimensional subspace induced by the learnable explicit feature map (LEFM) layer. Compared to the existing DN, the framework adds one hyperparameter and onl…
In this paper, we develop a complete pipeline for stain normalization, segmentation, and classification of nuclei in hematoxylin and eosin (H&E) stained breast cancer histopathology images. In the first step, we use a CNN-based stain transfer technique to normalize the staining characteristics of (H&E) images. We then train a neural network to segment images of nuclei from the H&E images. Finally, we train an Information Maximizing Generative Adversarial Network (InfoGAN) to learn visual representations of different types of nuclei and classify them in an entirely unsupervised manner. The resu…
Xi’an Jiao tong University（西安交通大学）；The First Affiliated Hospital of Xi’an Jiaotong University（西安交通大学第一附属医院）
Nuclei segmentation is a fundamental task in digital pathology analysis and can be automated by deep learning-based methods. However, the development of such an automated method requires a large amount of data with precisely annotated masks which is hard to obtain. Training with weakly labeled data is a popular solution for reducing the workload of annotation. In this paper, we propose a novel meta-learning-based nuclei segmentation method which follows the label correction paradigm to leverage data with noisy masks. Specifically, we design a fully conventional meta-model that can correct nois…
Semantic segmentation of breast cancer metastases in histopathological slides is a challenging task. In fact, significant variation in data characteristics of histopathology images (domain shift) make generalization of deep learning to unseen data difficult. Our goal is to address this challenge by using a conditional Fully Convolutional Network (co-FCN) whose output can be conditioned at run time, and which can improve its performance when a properly selected set of reference slides are used to condition the output. We adapted to our task a co-FCN originally applied to organs segmentation in …
Indian Institute of Information Technology Allahabad（阿拉哈巴德印度信息技术学院）
The use of Deep Learning (DL) based methods in medical histopathology images have been one of the most sought after solutions to classify, segment, and detect diseased biopsy samples. However, given the complex nature of medical datasets due to the presence of intra-class variability and heterogeneity, the use of complex DL models might not give the optimal performance up to the level which is suitable for assisting pathologists. Therefore, ensemble DL methods with the scope of including domain agnostic handcrafted Features (HC-F) inspired this work. We have, through experiments, tried to high…
Purpose: We aimed to develop deep machine learning (DL) models to improve the detection and segmentation of intraprostatic lesions (IL) on bp-MRI by using whole amount prostatectomy specimen-based delineations. We also aimed to investigate whether transfer learning and self-training would improve results with small amount labelled data. Methods: 158 patients had suspicious lesions delineated on MRI based on bp-MRI, 64 patients had ILs delineated on MRI based on whole mount prostatectomy specimen sections, 40 patients were unlabelled. A non-local Mask R-CNN was proposed to improve the segmentat…
Histopathological Spectrum-Guided Prostate Stratification via Segmentation-Assisted Diagnostic Transformer
College of Artificial Intelligence, Nankai University（南开大学人工智能学院）；Tianjin First Central Hospital（天津市第一中心医院）；School of Electronics and Information Engineering, Tiangong University（天津工业大学电子与信息工程学院）；School of Artificial Intelligence, Hebei University of Technology（河北工业大学人工智能学院）；North China Digital Health Technology Co., Ltd.（华北数字健康科技有限公司）；School of Computing and Information Systems, Singapore Management University（新加坡管理大学计算与信息系统学院）
Modern histopathological image analysis relies on the segmentation of cell structures to derive quantitative metrics required in biomedical research and clinical diagnostics. State-of-the-art deep learning approaches predominantly apply convolutional layers in segmentation and are typically highly customized for a specific experimental configuration; often unable to generalize to unknown data. As the model capacity of classical convolutional layers is limited by a finite set of learned kernels, our approach uses a graph representation of the image and focuses on the node transitions in multipl…
Northeastern University（东北大学）；Stevens Institute of Technology（史蒂文斯理工学院）；Cancer Hospital of China Medical University（中国医科大学附属肿瘤医院）；Chengdu University of Information Technology（成都信息工程大学）
Breast cancer is one of the most common and deadliest cancers among women. Since histopathological images contain sufficient phenotypic information, they play an indispensable role in the diagnosis and treatment of breast cancers. To improve the accuracy and objectivity of Breast Histopathological Image Analysis (BHIA), Artificial Neural Network (ANN) approaches are widely used in the segmentation and classification tasks of breast histopathological images. In this review, we present a comprehensive overview of the BHIA techniques based on ANNs. First of all, we categorize the BHIA systems int…
St. Olavs hospital, Trondheim University Hospital（圣奥拉夫医院，特隆赫姆大学医院）；NTNU - Norwegian University of Science and Technology（挪威科技大学）；University of Helsinki（赫尔辛基大学）；SINTEF Digital
Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase commercial solutions. We present a code-free pipeline utilizing free-to-use, open-source software (QuPath, DeepMIB, and FastPathology) for creating and deploying deep learning-based segmentation models for computational pathology. We demonstrate the pipeline on a use case of separating epithelium from stroma in colonic mucosa. A dataset of 251 annotated WSIs, comprising 140 hem…
Sejong University（世宗大学）；Kangbuk Samsung Hospital（江北三星医院）；Sungkyunkwan University School of Medicine（成均馆大学医学院）；Korea University（高丽大学）
An automated segmentation and classification of nuclei is an essential task in digital pathology. The current deep learning-based approaches require a vast amount of annotated datasets by pathologists. However, the existing datasets are imbalanced among different types of nuclei in general, leading to a substantial performance degradation. In this paper, we propose a simple but effective data augmentation technique, termed GradMix, that is specifically designed for nuclei segmentation and classification. GradMix takes a pair of a major-class nucleus and a rare-class nucleus, creates a customiz…
AWGUNET: Attention-Aided Wavelet Guided U-Net for Nuclei Segmentation in Histopathology Images
Jadavpur University（jadavpur大学）；Artificial Intelligence Research Institute, China University of Mining and Technology（中国矿业大学人工智能研究院）；Saint Petersburg Electrotechnical University "LETI"（圣彼得堡国立电工技术大学"LETI"）
We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part computes a segmentation of cell bodies, while the second module identifies the centers of these cells. Our model is trained end-to-end from scratch on a mouse parotid salivary gland stem cell nuclei dataset comprising 107 image stacks from three independent cell preparations, each containing several hundred individual cell nuclei in 3D. In our experiments, we …
Emory University（埃默里大学）；Stony Brook University（石溪大学）；Georgia State University（佐治亚州立大学）
Liver steatosis is known as the abnormal accumulation of lipids within cells. An accurate quantification of steatosis area within the liver histopathological microscopy images plays an important role in liver disease diagnosis and trans-plantation assessment. Such a quantification analysis often requires a precise steatosis segmentation that is challenging due to abundant presence of highly overlapped steatosis droplets. In this paper, a deep learning model Mask-RCNN is used to segment the steatosis droplets in clumps. Extended from Faster R-CNN, Mask-RCNN can predict object masks in addition …
UN-SAM: Universal Prompt-Free Segmentation for Generalized Nuclei Images
Centre for Artificial Intelligence and Robotics (CAIR), Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences（中国科学院香港创新研究院人工智能与机器人中心）；Chinese University of Hong Kong（香港中文大学）
The Deep Convolutional Neural Network (DCNN) is one of the most powerful and successful deep learning approaches. DCNNs have already provided superior performance in different modalities of medical imaging including breast cancer classification, segmentation, and detection. Breast cancer is one of the most common and dangerous cancers impacting women worldwide. In this paper, we have proposed a method for breast cancer classification with the Inception Recurrent Residual Convolutional Neural Network (IRRCNN) model. The IRRCNN is a powerful DCNN model that combines the strength of the Inception…
Segmentation-free integration of nuclei morphology and spatial transcriptomics for retinal images
Dept. of Information Technology（信息技术系）；Dept. of Molecular, Cell and Developmental Biology（分子、细胞与发育生物学系）；University of California, Los Angeles（加利福尼亚大学洛杉矶分校）
CB-HVTNet: A channel-boosted hybrid vision transformer network for lymphocyte assessment in histopathological images
Pakistan Institute of Engineering & Applied Sciences（巴基斯坦工程与应用科学学院）；Air University（空军大学）；Universiti Teknologi PETRONAS（马来西亚国油科技大学）；Korea National University of Transportation（韩国交通大学）
The grade of clear cell renal cell carcinoma (ccRCC) is a critical prognostic factor, making ccRCC nuclei grading a crucial task in RCC pathology analysis. Computer-aided nuclei grading aims to improve pathologists' work efficiency while reducing their misdiagnosis rate by automatically identifying the grades of tumor nuclei within histopathological images. Such a task requires precisely segment and accurately classify the nuclei. However, most of the existing nuclei segmentation and classification methods can not handle the inter-class similarity property of nuclei grading, thus can not be di…
Isfahan University of Technology（伊斯法罕理工大学）；McMaster University（麦克马斯特大学）
Digital pathology is one of the most significant developments in modern medicine. Pathological examinations are the gold standard of medical protocols and play a fundamental role in diagnosis. Recently, with the advent of digital scanners, tissue histopathology slides can now be digitized and stored as digital images. As a result, digitized histopathological tissues can be used in computer-aided image analysis programs and machine learning techniques. Detection and segmentation of nuclei are some of the essential steps in the diagnosis of cancers. Recently, deep learning has been used for nucl…
Equivariant Imaging Biomarkers for Robust Unsupervised Segmentation of Histopathology
Department of Biomedical Engineering, Yale University（生物医学工程系，耶鲁大学）；Department of Radiology & Biomedical Imaging, Yale University（放射科与生物医学成像系，耶鲁大学）；Department of Urology, Yale University（泌尿外科系，耶鲁大学）；Medical Scientist Training Program, Yale University（医学科学家培训计划，耶鲁大学）
A Hierarchical Transformer Encoder to Improve Entire Neoplasm Segmentation on Whole Slide Image of Hepatocellular Carcinoma
Université Paris Cité（巴黎西岱大学）；University of Applied Sciences of Western Switzerland (HES-SO Valais)（瑞士西部应用科学大学（瓦莱州高等专业学院））；French University Institute (IUF)（法国大学研究院）
针对肝细胞癌 WSI 全肿瘤分割难题，提出分层 Transformer 架构 HiTrans，在 4096×4096 图像块上学习全局依赖并提升分割性能。
University of Stavanger（斯塔万格大学）；Erasmus MC Cancer Institute, University Medical Center（伊拉斯姆斯医学中心癌症研究所，大学医学中心）
Accurate segmentation of tissue in histopathological images can be very beneficial for defining regions of interest (ROI) for streamline of diagnostic and prognostic tasks. Still, adapting to different domains is essential for histopathology image analysis, as the visual characteristics of tissues can vary significantly across datasets. Yet, acquiring sufficient annotated data in the medical domain is cumbersome and time-consuming. The labeling effort can be significantly reduced by leveraging active learning, which enables the selective annotation of the most informative samples. Our proposed…
Northeastern University（东北大学）；Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute（中国医科大学附属肿瘤医院、辽宁省肿瘤医院暨研究所）
Background and Purpose: Colorectal cancer is a common fatal malignancy, the fourth most common cancer in men, and the third most common cancer in women worldwide. Timely detection of cancer in its early stages is essential for treating the disease. Currently, there is a lack of datasets for histopathological image segmentation of rectal cancer, which often hampers the assessment accuracy when computer technology is used to aid in diagnosis. Methods: This present study provided a new publicly available Enteroscope Biopsy Histopathological Hematoxylin and Eosin Image Dataset for Image Segmentati…
Nuclei segmentation is a fundamental task that is critical for various computational pathology applications including nuclei morphology analysis, cell type classification, and cancer grading. Conventional vision-based methods for nuclei segmentation struggle in challenging cases and deep learning approaches have proven to be more robust and generalizable. However, CNNs require large amounts of labeled histopathology data. Moreover, conventional CNN-based approaches lack structured prediction capabilities which are required to distinguish overlapping and clumped nuclei. Here, we present an appr…
Nuclei segmentation is one of the important tasks for whole slide image analysis in digital pathology. With the drastic advance of deep learning, recent deep networks have demonstrated successful performance of the nuclei segmentation task. However, a major bottleneck to achieving good performance is the cost for annotation. A large network requires a large number of segmentation masks, and this annotation task is given to pathologists, not the public. In this paper, we propose a weakly supervised nuclei segmentation method, which requires only point annotations for training. This method can s…
University of New South Wales（新南威尔士大学）；University of Luebeck（吕贝克大学）；Northeastern University（东北大学）；China Medical University（中国医科大学）
In the past ten years, the computing power of machine vision (MV) has been continuously improved, and image analysis algorithms have developed rapidly. At the same time, histopathological slices can be stored as digital images. Therefore, MV algorithms can provide doctors with diagnostic references. In particular, the continuous improvement of deep learning algorithms has further improved the accuracy of MV in disease detection and diagnosis. This paper reviews the applications of image processing technology based on MV in lymphoma histopathological images in recent years, including segmentati…
Berlin Institute of Health（柏林健康研究所）；Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association（亥姆霍兹协会马克斯·德尔布吕克分子医学中心）
Segmentation of cell nuclei in microscopy images is a prevalent necessity in cell biology. Especially for three-dimensional datasets, manual segmentation is prohibitively time-consuming, motivating the need for automated methods. Learning-based methods trained on pixel-wise ground-truth segmentations have been shown to yield state-of-the-art results on 2d benchmark image data of nuclei, yet a respective benchmark is missing for 3d image data. In this work, we perform a comparative evaluation of nuclei segmentation algorithms on a database of manually segmented 3d light microscopy volumes. We p…
University of Idaho（爱达荷大学）；Hunan University of Technology of Business（湖南工商大学）
Separating overlapped nuclei is a major challenge in histopathology image analysis. Recently published approaches have achieved promising overall performance on nuclei segmentation; however, their performance on separating overlapped nuclei is quite limited. To address the issue, we propose a novel multitask learning network with a bending loss regularizer to separate overlapped nuclei accurately. The newly proposed multitask learning architecture enhances the generalization by learning shared representation from three tasks: instance segmentation, nuclei distance map prediction, and overlappe…
Nucleus segmentation and classification are the prerequisites in the workflow of digital pathology processing. However, it is very challenging due to its high-level heterogeneity and wide variations. This work proposes a deep neural network to simultaneously achieve nuclear classification and segmentation, which is designed using a unified framework with three different branches, including segmentation, HoVer mapping, and classification. The segmentation branch aims to generate the boundaries of each nucleus. The HoVer branch calculates the horizontal and vertical distances of nuclear pixels t…
Histopathological image segmentation is a challenging and important topic in medical imaging with tremendous potential impact in clinical practice. State of the art methods rely on hand-crafted annotations which hinder clinical translation since histology suffers from significant variations between cancer phenotypes. In this paper, we propose a weakly supervised framework for whole slide imaging segmentation that relies on standard clinical annotations, available in most medical systems. In particular, we exploit a multiple instance learning scheme for training models. The proposed framework h…
Norwegian University of Science and Technology（挪威科技大学）；St. Olavs Hospital, Trondheim University Hospital（圣奥拉夫医院，特隆赫姆大学医院）；SINTEF Digital（挪威科技工业研究院数字研究所）
Histopathological cancer diagnostics has become more complex, and the increasing number of biopsies is a challenge for most pathology laboratories. Thus, development of automatic methods for evaluation of histopathological cancer sections would be of value. In this study, we used 624 whole slide images (WSIs) of breast cancer from a Norwegian cohort. We propose a cascaded convolutional neural network design, called H2G-Net, for semantic segmentation of gigapixel histopathological images. The design involves a detection stage using a patch-wise method, and a refinement stage using a convolution…
Deep cerebellar nuclei are a key structure of the cerebellum that are involved in processing motor and sensory information. It is thus a crucial step to accurately segment deep cerebellar nuclei for the understanding of the cerebellum system and its utility in deep brain stimulation treatment. However, it is challenging to clearly visualize such small nuclei under standard clinical magnetic resonance imaging (MRI) protocols and therefore precise segmentation is not feasible. Recent advances in 7 Tesla (T) MRI technology and great potential of deep neural networks facilitate automatic patient-s…
This paper presents a new regularization method to train a fully convolutional network for semantic tissue segmentation in histopathological images. This method relies on the benefit of unsupervised learning, in the form of image reconstruction, for network training. To this end, it puts forward an idea of defining a new embedding that allows uniting the main supervised task of semantic segmentation and an auxiliary unsupervised task of image reconstruction into a single one and proposes to learn this united task by a single generative model. This embedding generates an output image by superim…
The size of nuclei in histological preparations from excised breast tumors is predictive of patient outcome (large nuclei indicate poor outcome). Pathologists take into account nuclear size when performing breast cancer grading. In addition, the mean nuclear area (MNA) has been shown to have independent prognostic value. The straightforward approach to measuring nuclear size is by performing nuclei segmentation. We hypothesize that given an image of a tumor region with known nuclei locations, the area of the individual nuclei and region statistics such as the MNA can be reliably computed direc…
ADNP-15: An Open-Source Histopathological Dataset for Neuritic Plaque Segmentation in Human Brain Whole Slide Images with Frequency Domain Image Enhancement for Stain Normalization
School of Software Engineering, Beijing University of Technology（北京工业大学软件学院）；Sorbonne Université（索邦大学）；Institut du Cerveau - Paris Brain Institute - ICM（巴黎脑研究所-巴黎脑研究所-ICM）；Inserm（法国国家医学院）；CNRS（法国国家科学研究中心）；APHP（法国国家卫生与医学研究院）；Hôpital de la Pitié Salpêtrière（皮蒂埃萨尔佩特里医院）；DMU Neuroscience（DMU神经科学）；Inria（法国国家信息与自动化技术研究院）
Rutgers University（罗格斯大学）；SenseBrain Technology Limited LLC（SenseBrain科技有限公司）；Rutgers New Jersey Medical School（罗格斯大学新泽西医学院）；SenseTime Research（商汤科技研究院）；Rutgers Cancer Institute of New Jersey（罗格斯大学新泽西癌症研究所）
Nuclei segmentation is a fundamental task in histopathology image analysis. Typically, such segmentation tasks require significant effort to manually generate accurate pixel-wise annotations for fully supervised training. To alleviate such tedious and manual effort, in this paper we propose a novel weakly supervised segmentation framework based on partial points annotation, i.e., only a small portion of nuclei locations in each image are labeled. The framework consists of two learning stages. In the first stage, we design a semi-supervised strategy to learn a detection model from partially lab…
Emory University（埃默里大学）；University of Brasília（巴西利亚大学）；Northwestern University（西北大学）
Highly clumped nuclei clusters captured in fluorescence in situ hybridization microscopy images are common histology entities under investigations in a wide spectrum of tissue-related biomedical investigations. Due to their large scale in presence, computer based image analysis is used to facilitate such analysis with improved analysis efficiency and reproducibility. To ensure the quality of downstream biomedical analyses, it is essential to segment clustered nuclei with high quality. However, this presents a technical challenge commonly encountered in a large number of biomedical research, as…
Prompt-Free Lightweight SAM Adaptation for Histopathology Nuclei Segmentation with Strong Cross-Dataset Generalization
School of Information and Communication Technology, Griffith University, QLD, Australia（信息与通信技术学院，格里菲斯大学，昆士兰，澳大利亚）；School of MDP -- Clinical Medicine, Griffith University, QLD, Australia（MDP临床医学学院，格里菲斯大学，昆士兰，澳大利亚）
University College London（伦敦大学学院）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；MIT（麻省理工学院）；Technical University of Denmark（丹麦技术大学）
Segmentation of structural and diffusion MRI (sMRI/dMRI) is usually performed independently in neuroimaging pipelines. However, some brain structures (e.g., globus pallidus, thalamus and its nuclei) can be extracted more accurately by fusing the two modalities. Following the framework of Bayesian segmentation with probabilistic atlases and unsupervised appearance modeling, we present here a novel algorithm to jointly segment multi-modal sMRI/dMRI data. We propose a hierarchical likelihood term for the dMRI defined on the unit ball, which combines the Beta and Dimroth-Scheidegger-Watson distrib…
CellPilot: A unified approach to automatic and interactive segmentation in histopathology
School of Computation and Information Technology, Technical University of Munich（慕尼黑工业大学计算与信息技术学院）；Helmholtz Zentrum München - German Research Center for Environmental Health（亥姆霍兹慕尼黑中心——德国环境健康研究中心）；School of Biomedical Engineering and Imaging Sciences, King’s College London（伦敦国王学院生物医学工程与影像科学学院）
ACS-SegNet: An Attention-Based CNN-SegFormer Segmentation Network for Tissue Segmentation in Histopathology
Research Center for Medical Image Analysis（医学图像分析研究中心）；Artificial Intelligence, Department of Medicine, Faculty of Medicine（人工智能，医学系，医学学院）；Dentistry, Danube Private University Department of Pathophysiology（牙科，丹ube私立大学病理学系）；Allergy Research, Center of Pathophysiology, Infectiology（过敏研究，病理学中心，感染学）；Immunology, Medical University of Vienna Comprehensive Center for AI in Medicine (CAIM), Medical University of Vienna（免疫学，维也纳医学大学人工智能医学中心（CAIM），维也纳医学大学）
Johns Hopkins University（约翰斯·霍普金斯大学）；Max Planck Institute for Informatics（马克斯·普朗克信息学研究所）
The field of computational pathology has witnessed great advancements since deep neural networks have been widely applied. These networks usually require large numbers of annotated data to train vast parameters. However, it takes significant effort to annotate a large histopathology dataset. We introduce a light-weight and interpretable model for nuclei detection and weakly-supervised segmentation. It only requires annotations on isolated nucleus, rather than on all nuclei in the dataset. Besides, it is a generative compositional model that first locates parts of nucleus, then learns the spati…
GDBA-Net: A Gated Dual-Branch Adaptation of SAM2 for Robust Cross-Domain Nuclei Segmentation
University of Missouri（密苏里大学）；Lander University（兰德大学）；Sagarmatha Engineering College, Tribhuvan University（萨加玛塔工程学院，特里布万大学）；Morsani College of Medicine, University of South Florida（莫尔萨尼医学院，南佛罗里达大学）
King’s College London（伦敦国王学院）；Indian Institute of Technology Bombay（印度理工学院孟买分校）；Tianjin Medical University Cancer Institute & Hospital（天津医科大学肿瘤医院）
Although the U-Net architecture has been extensively used for segmentation of medical images, we address two of its shortcomings in this work. Firstly, the accuracy of vanilla U-Net degrades when the target regions for segmentation exhibit significant variations in shape and size. Even though the U-Net already possesses some capability to analyze features at various scales, we propose to explicitly add multi-scale feature maps in each convolutional module of the U-Net encoder to improve segmentation of histology images. Secondly, the accuracy of a U-Net model also suffers when the annotations …
Due to the increasing availability of whole slide scanners facilitating digitization of histopathological tissue, there is a strong demand for the development of computer based image analysis systems. In this work, the focus is on the segmentation of the glomeruli constituting a highly relevant structure in renal histopathology, which has not been investigated before in combination with CNNs. We propose two different CNN cascades for segmentation applications with sparse objects. These approaches are applied to the problem of glomerulus segmentation and compared with conventional fully-convolu…
