arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2201.03669eess.IVcs.CVq-bio.QM
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用于组织病理学图像中细胞核分割的神经可塑图注意网络

Neuroplastic graph attention networks for nuclei segmentation in histopathology images

University of Leicester(莱斯特大学)

Yoav Alon, Huiyu Zhou

摘要:

现代组织病理学图像分析依赖于细胞结构的分割,以获得生物医学研究和临床诊断所需的定量指标。最先进的深度学习方法主要在分割中应用卷积层,并且通常针对特定的实验配置进行高度定制;通常无法推广到未知数据。由于经典卷积层的模型容量受到有限的学习内核集的限制,我们的方法使用图像的图形表示,并专注于多个放大倍数的节点转换。我们提出了一种新的架构,细胞核的语义分割强大的实验配置,如染色和细胞类型的变化的差异。该架构是由一个新的神经可塑性图形注意网络的基础上残留的图形注意层和并发优化的图形结构表示多个放大级别的组织病理学图像。图结构的修改,即通过投影生成节点特征,对于图神经网络本身的架构同样重要。它确定了可能的消息流和关键属性,以优化注意力,图形结构和平衡放大损失的节点更新。在实验评估中,我们的框架优于最先进的神经网络,通常需要一小部分神经元,并为新的细胞核数据集的分割设定了新的标准。

英文摘要:

Modern histopathological image analysis relies on the segmentation of cell structures to derive quantitative metrics required in biomedical research and clinical diagnostics. State-of-the-art deep learning approaches predominantly apply convolutional layers in segmentation and are typically highly customized for a specific experimental configuration; often unable to generalize to unknown data. As the model capacity of classical convolutional layers is limited by a finite set of learned kernels, our approach uses a graph representation of the image and focuses on the node transitions in multiple magnifications. We propose a novel architecture for semantic segmentation of cell nuclei robust to differences in experimental configuration such as staining and variation of cell types. The architecture is comprised of a novel neuroplastic graph attention network based on residual graph attention layers and concurrent optimization of the graph structure representing multiple magnification levels of the histopathological image. The modification of graph structure, which generates the node features by projection, is as important to the architecture as the graph neural network itself. It determines the possible message flow and critical properties to optimize attention, graph structure, and node updates in a balanced magnification loss. In experimental evaluation, our framework outperforms ensembles of state-of-the-art neural networks, with a fraction of the neurons typically required, and sets new standards for the segmentation of new nuclei datasets.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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