鸟类 prestin 的膜厚度敏感性：推论
Membrane Thickness Sensitivity of Avian Prestin: Implications
AI总结：
本文提出鸟类 prestin 虽无膜面积变化，但可通过膜蛋白剪切变形的构象转变实现运动功能，从而解释其膜厚度敏感性。
摘要：
鸟类 prestin 对膜厚度的敏感性与哺乳动物 prestin 相当，后者在膜面积上发生构象转变，从而驱动外毛细胞圆柱形胞体的长度变化。哺乳动物 prestin 的膜厚度依赖性源于构象状态中疏水分布的变化，并伴随其膜面积的改变。尽管在鸟类 prestin 中未检测到此类面积变化，它仍能使鸟类短毛细胞的毛束发生弯曲。本文提出，鸟类 prestin 的运动功能可能基于涉及膜蛋白剪切变形的构象转变，这种转变同样导致膜厚度敏感性。
英文摘要：
Avian prestin is sensitive to membrane thickness as much as mammalian prestin, which undergoes conformational transitions in membrane area and thereby drives length changes of the cylindrical cell body of outer hair cells. The membrane thickness dependence of mammalian prestin stems from changes in hydrophobic profile in conformational states, accompanied by changes in their membrane area. Even though such area changes are not detected for avian prestin, it nonetheless bends hair bundles of avian short hair cells. Here it is suggested that the motile function of avian prestin can be based on conformational transitions involving shearing deformation of the membrane protein, which also leads to membrane thickness sensitivity.
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