Frequency dependence of prestin: Intrinsic transition rates and viscoelastic relaxation
英文摘要：
Outer hair cells in the inner ear is important for the sensitivity, frequency selectivity, and dynamic range of the mammalian ear. Such a physiological role of outer hair cells is thought to be based an amplifying effect of those cells, which have mechanosensitive their hair bundles and motile cell body embedding prestin, a membrane protein with electromechanical coupling at high density. Mechanical power production by outer hair cells were previously evaluated based on an assumption that the intrinsic transition rates of this motile protein is faster than the operating frequency. This report generalizes the previous treatment by incorporating intrinsic transition rates of the motile membrane protein. It was found that the transition rates attenuates mechanical power production of an outer hair cell such that viscous drag cannot be counteracted beyond the characteristic frequency of gating.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
