并非如此presto？外毛细胞中迟缓的prestin的结果
Not so presto? Outcomes of sluggish prestin in outer hair cells
AI总结：
本文通过简单压电模型，检验prestin蛋白转变率低及外毛细胞运动振幅下降等新观察结果是否与其生理功能相容，以重新评估其是否支持匹配哺乳动物听觉范围的快速运动。
摘要：
Prestin（SLC26A5）是哺乳动物耳朵灵敏度所必需的蛋白质，其名称源自presto。该假设认为这种膜蛋白支持外毛细胞的快速运动，以匹配哺乳动物的听觉范围，通常高达20 kHz甚至更高，具体取决于物种。来自分离OHCs的体外数据似乎与这些频率一致。然而，最近的一些报告对该假设提出质疑，表明该蛋白质的内在转变率要低得多，豚鼠约为3 kHz，未覆盖该动物的听觉频率范围。最近的体内数据也显示，OHC运动的振幅在该位置最佳频率以下显著下降。本报告通过使用简单的压电模型，检验这些近期观察结果是否与OHCs的生理功能相容。
英文摘要：
Prestin (SLC26A5), a protein essential for the sensitivity of the mammalian ear, was so named from \emph{presto}. The assumption was that this membrane protein supports fast movement of outer hair cells (OHCs) that matches the mammalian hearing range, up to 20 kHz in general and beyond, depending on the species. \emph{In vitro} data from isolated OHCs appeared to be consistent with such frequencies. However, some recent reports cast doubts on this assumption, suggesting that the intrinsic transition rates of this protein are much lower, about 3 kHz for guinea pigs, not covering the auditory frequency range of the animal. Recent \emph{in vivo} data also show that the amplitude of OHC motion rolls off well below the best frequency of the location. The present report examines whether or not these resent observations are compatible with the physiological function of OHCs by using simple piezoelectric models.
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