Tensor-based Multimodal Learning for Prediction of Pulmonary Arterial Wedge Pressure from Cardiac MRI
University of Sheffield（谢菲尔德大学）；Sheffield Teaching Hospitals（谢菲尔德教学医院）；INSIGNEO, Institute for in Silico Medicine, University of Sheffield（谢菲尔德大学INSIGNEO计算机模拟医学研究所）；Centre for Machine Intelligence, University of Sheffield（谢菲尔德大学机器智能中心）
Prasun C. Tripathi, Mohammod N. I. Suvon, Lawrence Schobs, Shuo Zhou, Samer Alabed, Andrew J. Swift, Haiping Lu
Heart failure is a serious and life-threatening condition that can lead to elevated pressure in the left ventricle. Pulmonary Arterial Wedge Pressure (PAWP) is an important surrogate marker indicating high pressure in the left ventricle. PAWP is determined by Right Heart Catheterization (RHC) but it is an invasive procedure. A non-invasive method is useful in quickly identifying high-risk patients from a large population. In this work, we develop a tensor learning-based pipeline for identifying PAWP from multimodal cardiac Magnetic Resonance Imaging (MRI). This pipeline extracts spatial and temporal features from high-dimensional scans. For quality control, we incorporate an epistemic uncertainty-based binning strategy to identify poor-quality training samples. To improve the performance, we learn complementary information by integrating features from multimodal data: cardiac MRI with short-axis and four-chamber views, and Electronic Health Records. The experimental analysis on a large cohort of $1346$ subjects who underwent the RHC procedure for PAWP estimation indicates that the proposed pipeline has a diagnostic value and can produce promising performance with significant improvement over the baseline in clinical practice (i.e., $Δ$AUC $=0.10$, $Δ$Accuracy $=0.06$, and $Δ$MCC $=0.39$). The decision curve analysis further confirms the clinical utility of our method.
Image2Flow: A hybrid image and graph convolutional neural network for rapid patient-specific pulmonary artery segmentation and CFD flow field calculation from 3D cardiac MRI data
Institute of Cardiovascular Science, University College London（伦敦大学学院心血管科学研究所）
Explainable Cross-Disease Reasoning for Cardiovascular Risk Assessment from Low-Dose Computed Tomography
Department of Computer Science, Emory University（埃默里大学计算机科学系）；Department of Computer Science, Johns Hopkins University（约翰霍普金斯大学计算机科学系）；Department of Radiation Oncology（放射肿瘤学部）；Winship Cancer Institute, Emory University（埃默里大学Winship癌症研究所）
UNSW（新南威尔士大学）；Victor Chang Cardiac Research Institute（维克多·张心脏研究所）
Heart failure (HF) is one of the most prevalent life-threatening cardiovascular diseases in which 6.5 million people are suffering in the USA and more than 23 million worldwide. Mechanical circulatory support of HF patients can be achieved by implanting a left ventricular assist device (LVAD) into HF patients as a bridge to transplant, recovery or destination therapy and can be controlled by measurement of normal and abnormal pulmonary arterial wedge pressure (PAWP). While there are no commercial long-term implantable pressure sensors to measure PAWP, real-time non-invasive estimation of abnor…
Center for Research in Computer Vision (CRCV), University of Central Florida（中佛罗里达大学计算机视觉研究中心）；Diagnostic Radiology Department, Florida Hospital（佛罗里达医院放射诊断科）
Non-invasive detection of cardiovascular disorders from radiology scans requires quantitative image analysis of the heart and its substructures. There are well-established measurements that radiologists use for diseases assessment such as ejection fraction, volume of four chambers, and myocardium mass. These measurements are derived as outcomes of precise segmentation of the heart and its substructures. The aim of this paper is to provide such measurements through an accurate image segmentation algorithm that automatically delineates seven substructures of the heart from MRI and/or CT scans. O…
ETH Zürich（苏黎世联邦理工学院）；University Children’s Hospital Regensburg (KUNO)（雷根斯堡大学儿童医院（KUNO））
Pulmonary hypertension (PH) in newborns and infants is a complex condition associated with several pulmonary, cardiac, and systemic diseases contributing to morbidity and mortality. Therefore, accurate and early detection of PH is crucial for successful management. Using echocardiography, the primary diagnostic tool in pediatrics, human assessment is both time-consuming and expertise-demanding, raising the need for an automated approach. In this work, we present an interpretable multi-view video-based deep learning approach to predict PH for a cohort of 194 newborns using echocardiograms. We u…
Markov Chain Monte Carlo with Gaussian Process Emulation for a 1D Hemodynamics Model of CTEPH
Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center, Department of Biomedical Engineering, University of California, Irvine（加州大学尔湾分校生物医学工程系爱德华兹生命科学基金会心血管创新与研究中心）
Pulmonary embolisms (PE) are known to be one of the leading causes for cardiac-related mortality. Due to inherent variabilities in how PE manifests and the cumbersome nature of manual diagnosis, there is growing interest in leveraging AI tools for detecting PE. In this paper, we build a two-stage detection pipeline that is accurate, computationally efficient, robust to variations in PE types and kernels used for CT reconstruction, and most importantly, does not require dense annotations. Given the challenges in acquiring expert annotations in large-scale datasets, our approach produces state-o…
At-Admission Prediction of Mortality and Pulmonary Embolism in COVID-19 Patients Using Statistical and Machine Learning Methods: An International Cohort Study
University of Oxford（牛津大学）；Institute for Clinical Research, National Institutes of Health (NIH), Malaysia（马来西亚国立卫生研究院临床研究所）；Amsterdam University Medical Center（阿姆斯特丹大学医学中心）
Mannheim University of Applied Science（曼海姆应用科技大学）；UT Southwestern Medical Center（德克萨斯大学西南医学中心）；DZHK (German Centre for Cardiovascular Research)（德国心血管研究中心）；German Heart Centre Munich（慕尼黑德国心脏中心）；Hannover Medical School（汉诺威医学院）；Heidelberg University Hospital（海德堡大学医院）
Planning the optimal time of intervention for pulmonary valve replacement surgery in patients with the congenital heart disease Tetralogy of Fallot (TOF) is mainly based on ventricular volume and function according to current guidelines. Both of these two biomarkers are most reliably assessed by segmentation of 3D cardiac magnetic resonance (CMR) images. In several grand challenges in the last years, U-Net architectures have shown impressive results on the provided data. However, in clinical practice, data sets are more diverse considering individual pathologies and image properties derived fr…
University of Amsterdam（阿姆斯特丹大学）；University Medical Center Utrecht（乌得勒支大学医学中心）
Deep learning-based whole-heart segmentation in coronary CT angiography (CCTA) allows the extraction of quantitative imaging measures for cardiovascular risk prediction. Automatic extraction of these measures in patients undergoing only non-contrast-enhanced CT (NCCT) scanning would be valuable. In this work, we leverage information provided by a dual-layer detector CT scanner to obtain a reference standard in virtual non-contrast (VNC) CT images mimicking NCCT images, and train a 3D convolutional neural network (CNN) for the segmentation of VNC as well as NCCT images. Contrast-enhanced acquis…
Real-Time Surrogate Modeling for Personalized Blood Flow Prediction and Hemodynamic Analysis
Laboratory of Hemodynamics and Cardiovascular Technology, EPFL（EPFL血液动力学与心血管技术实验室）；Stanford DBDS and HAI, Stanford University（斯坦福大学DBDS与HAI）；Medical School, National and Kapodistrian University of Athens（雅典大学医学院）
Evaluation of state-of-the-art deep learning models in the segmentation of the heart ventricles in parasternal short-axis echocardiograms
Southern Illinois University Edwardsville（南伊利诺伊大学爱德华兹维尔分校）；The Johns Hopkins University School of Medicine（约翰霍普金斯大学医学院）；Columbus Regional Hospital（哥伦布地区医院）；St. Louis Community College（圣路易斯社区学院）
