Pneumonia, a respiratory infection brought on by bacteria or viruses, affects a large number of people, especially in developing and impoverished countries where high levels of pollution, unclean living conditions, and overcrowding are frequently observed, along with insufficient medical infrastructure. Pleural effusion, a condition in which fluids fill the lung and complicate breathing, is brought on by pneumonia. Early detection of pneumonia is essential for ensuring curative care and boosting survival rates. The approach most usually used to diagnose pneumonia is chest X-ray imaging. The purpose of this work is to develop a method for the automatic diagnosis of bacterial and viral pneumonia in digital x-ray pictures. This article first presents the authors' technique, and then gives a comprehensive report on recent developments in the field of reliable diagnosis of pneumonia. In this study, here tuned a state-of-the-art deep convolutional neural network to classify plant diseases based on images and tested its performance. Deep learning architecture is compared empirically. VGG19, ResNet with 152v2, Resnext101, Seresnet152, Mobilenettv2, and DenseNet with 201 layers are among the architectures tested. Experiment data consists of two groups, sick and healthy X-ray pictures. To take appropriate action against plant diseases as soon as possible, rapid disease identification models are preferred. DenseNet201 has shown no overfitting or performance degradation in our experiments, and its accuracy tends to increase as the number of epochs increases. Further, DenseNet201 achieves state-of-the-art performance with a significantly a smaller number of parameters and within a reasonable computing time. This architecture outperforms the competition in terms of testing accuracy, scoring 95%. Each architecture was trained using Keras, using Theano as the backend.
University of Dhaka(达卡大学);Qatar University(卡塔尔大学);Bangabandhu Sheikh Mujib Medical University(邦班杜·谢赫·穆吉布医科大学);North South University(北南大学);Qatar Armed Forces-Academic Bridge Program(卡塔尔武装部队-学术桥梁计划);Qatar Foundation(卡塔尔基金会)
Pneumonia is a life-threatening disease, which occurs in the lungs caused by either bacterial or viral infection. It can be life-endangering if not acted upon in the right time and thus an early diagnosis of pneumonia is vital. The aim of this paper is to automatically detect bacterial and viral pneumonia using digital x-ray images. It provides a detailed report on advances made in making accurate detection of pneumonia and then presents the methodology adopted by the authors. Four different pre-trained deep Convolutional Neural Network (CNN)- AlexNet, ResNet18, DenseNet201, and SqueezeNet wer…
Pneumonia App: a mobile application for efficient pediatric pneumonia diagnosis using explainable convolutional neural networks (CNN)
Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, The Fifth Affiliated Hospital of Wenzhou Medical University(温州医科大学附属第五医院);Tsinghua-Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University(清华大学深圳国际研究生院清华-伯克利深圳学院);Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University(清华大学深圳国际研究生院生物医药与健康工程研究院);Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University(清华大学化学工程系工业生物催化教育部重点实验室);State Key Laboratory of Urban Water Resources and Environment, School of Civil & Environmental Engineering, Harbin Institute of Technology (Shenzhen)(哈尔滨工业大学(深圳)土木与环境工程学院城市水资源与水环境国家重点实验室);Department of Radiology, The University of Hong Kong - Shenzhen Hospital(香港大学深圳医院放射科)
School of Electrical and Computer Engineering, University of Oklahoma(俄克拉荷马大学电气与计算机工程学院);University of California Santa Cruz(加州大学圣克鲁兹分校)
As the rapid spread of coronavirus disease (COVID-19) worldwide, chest X-ray radiography has also been used to detect COVID-19 infected pneumonia and assess its severity or monitor its prognosis in the hospitals due to its low cost, low radiation dose, and wide accessibility. However, how to more accurately and efficiently detect COVID-19 infected pneumonia and distinguish it from other community-acquired pneumonia remains a challenge. In order to address this challenge, we in this study develop and test a new computer-aided diagnosis (CAD) scheme. It includes several image pre-processing algo…
Automatic Chest Radiograph X-ray (CXR) interpretation by machines is an important research topic of Artificial Intelligence. As part of my journey through the California Science Fair, I have developed an algorithm that can detect pneumonia from a CXR image to compensate for human fallibility. My algorithm, PneumoXttention, is an ensemble of two 13 layer convolutional neural network trained on the RSNA dataset, a dataset provided by the Radiological Society of North America, containing 26,684 frontal X-ray images split into the categories of pneumonia and no pneumonia. The dataset was annotated…
Indian Institute of Technology, Jammu(印度理工学院贾姆姆分校);University of Pennsylvania(宾夕法尼亚大学)
We propose a two-stage Convolutional Neural Network (CNN) based classification framework for detecting COVID-19 and Community-Acquired Pneumonia (CAP) using the chest Computed Tomography (CT) scan images. In the first stage, an infection - COVID-19 or CAP, is detected using a pre-trained DenseNet architecture. Then, in the second stage, a fine-grained three-way classification is done using EfficientNet architecture. The proposed COVID+CAP-CNN framework achieved a slice-level classification accuracy of over 94% at identifying COVID-19 and CAP. Further, the proposed framework has the potential t…
Dedan Kimathi University of Technology(德丹·基马蒂理工大学)
Chest X-rays remains to be the most common imaging modality used to diagnose lung diseases. However, they necessitate the interpretation of experts (radiologists and pulmonologists), who are few. This review paper investigates the use of deep transfer learning techniques to detect COVID-19, pneumonia, and tuberculosis in chest X-ray (CXR) images. It provides an overview of current state-of-the-art CXR image classification techniques and discusses the challenges and opportunities in applying transfer learning to this domain. The paper provides a thorough examination of recent research studies t…
Iran University of Science and Technology(伊朗科技大学);Sharif University of Technology(谢里夫理工大学)
In this paper, we have trained several deep convolutional networks with introduced training techniques for classifying X-ray images into three classes: normal, pneumonia, and COVID-19, based on two open-source datasets. Our data contains 180 X-ray images that belong to persons infected with COVID-19, and we attempted to apply methods to achieve the best possible results. In this research, we introduce some training techniques that help the network learn better when we have an unbalanced dataset (fewer cases of COVID-19 along with more cases from other classes). We also propose a neural network…
Institute of Medical Science, University of Toronto(多伦多大学医学科学研究所);The Hospital for Sick Children(病童医院);University Health Network(大学健康网络);Department of Mechanical and Industrial Engineering, University of Toronto(多伦多大学机械与工业工程系)
Successful training of convolutional neural networks (CNNs) requires a substantial amount of data. With small datasets networks generalize poorly. Data Augmentation techniques improve the generalizability of neural networks by using existing training data more effectively. Standard data augmentation methods, however, produce limited plausible alternative data. Generative Adversarial Networks (GANs) have been utilized to generate new data and improve the performance of CNNs. Nevertheless, data augmentation techniques for training GANs are under-explored compared to CNNs. In this work, we propos…
Pneumonia is one of the most acute respiratory diseases having remarkably high prevalence and mortality rate. Chest X-ray (CXR) has been widely utilized for the diagnosis of this disease owing to its availability, diagnostic speed and accuracy. However, even for an expert radiologist, it is quite challenging to readily determine pneumonia opacity by examining CXRs. Therefore, this study has been structured to automate the pneumonia detection process by introducing a robust deep learning framework. The proposed network comprises of Process Convolution (Pro_Conv) blocks for feature accumulation …
University of Saskatchewan(萨斯喀彻温大学);International Road Dynamics(国际道路动力学公司);National Institute of Technology, Trichy(特里奇国家理工学院)
One of the primary clinical observations for screening the infectious by the novel coronavirus is capturing a chest x-ray image. In most of the patients, a chest x-ray contains abnormalities, such as consolidation, which are the results of COVID-19 viral pneumonia. In this study, research is conducted on efficiently detecting imaging features of this type of pneumonia using deep convolutional neural networks in a large dataset. It is demonstrated that simple models, alongside the majority of pretrained networks in the literature, focus on irrelevant features for decision-making. In this paper,…
Deep Learning-Based Pneumonia Detection from Chest X-ray Images: A CNN Approach with Performance Analysis and Clinical Implications
Amity Institute of Bio Technology, Amity University Kolkata(阿米蒂大学加尔各答分校阿米蒂生物技术学院);Dept of Computer Science, Heritage Institute of Technology, Kolkata(加尔各答遗产技术学院计算机科学系);School of Engineering and Technology, Amity University Kolkata(阿米蒂大学加尔各答分校工程与技术学院)
The world is still overwhelmed by the spread of the COVID-19 virus. With over 250 Million infected cases as of November 2021 and affecting 219 countries and territories, the world remains in the pandemic period. Detecting COVID-19 using the deep learning method on CT scan images can play a vital role in assisting medical professionals and decision authorities in controlling the spread of the disease and providing essential support for patients. The convolution neural network is widely used in the field of large-scale image recognition. The current method of RT-PCR to diagnose COVID-19 is time-…
The worldwide spread of pneumonia caused by a novel coronavirus poses an unprecedented challenge to the world's medical resources and prevention and control measures. Covid-19 attacks not only the lungs, making it difficult to breathe and life-threatening, but also the heart, kidneys, brain and other vital organs of the body, with possible sequela. At present, the detection of COVID-19 needs to be realized by the reverse transcription-polymerase Chain Reaction (RT-PCR). However, many countries are in the outbreak period of the epidemic, and the medical resources are very limited. They cannot p…
Koya University(科亚大学);Oxford Drug Design(牛津药物设计公司);Salahaddin University-Erbil(埃尔比勒萨拉赫丁大学);University of Wolverhampton(伍尔弗汉普顿大学);King Saud University(沙特国王大学)
COVID-19 (also known as 2019 Novel Coronavirus) first emerged in Wuhan, China and spread across the globe with unprecedented effect and has now become the greatest crisis of the modern era. The COVID-19 has proved much more pervasive demands for diagnosis that has driven researchers to develop more intelligent, highly responsive and efficient detection methods. In this work, we focus on proposing AI tools that can be used by radiologists or healthcare professionals to diagnose COVID-19 cases in a quick and accurate manner. However, the lack of a publicly available dataset of X-ray and CT image…
With the advancement in AI, deep learning techniques are widely used to design robust classification models in several areas such as medical diagnosis tasks in which it achieves good performance. In this paper, we have proposed the CNN model (Convolutional Neural Network) for the classification of Chest X-ray images for Radiological Society of North America Pneumonia (RSNA) datasets. The study also tries to achieve the same RSNA benchmark results using the limited computational resources by trying out various approaches to the methodologies that have been implemented in recent years. The propo…
Pneumonia is a lung infection that causes 15% of childhood mortality, over 800,000 children under five every year, all over the world. This pathology is mainly caused by viruses or bacteria. X-rays imaging analysis is one of the most used methods for pneumonia diagnosis. These clinical images can be analyzed using machine learning methods such as convolutional neural networks (CNN), which learn to extract critical features for the classification. However, the usability of these systems is limited in medicine due to the lack of interpretability, because of these models cannot be used to generat…
Mohammed VI Polytechnic University(穆罕默德六世理工大学);Moulay Ismail University(穆莱·伊斯梅尔大学);University Mohammed V in Rabat(拉巴特穆罕默德五世大学);ENSIAS(国立统计与应用经济学院)
Recently, researchers, specialists, and companies around the world are rolling out deep learning and image processing-based systems that can fastly process hundreds of X-Ray and computed tomography (CT) images to accelerate the diagnosis of pneumonia such as SARS, COVID-19, and aid in its containment. Medical images analysis is one of the most promising research areas, it provides facilities for diagnosis and making decisions of a number of diseases such as MERS, COVID-19. In this paper, we present a comparison of recent Deep Convolutional Neural Network (DCNN) architectures for automatic bina…
Fudan University(复旦大学);Inception Institute of Artificial Intelligence(人工智能 inception 研究所);Shanghai Public Health Clinical Center, Fudan University(复旦大学附属上海公共卫生临床中心)
To counter the outbreak of COVID-19, the accurate diagnosis of suspected cases plays a crucial role in timely quarantine, medical treatment, and preventing the spread of the pandemic. Considering the limited training cases and resources (e.g, time and budget), we propose a Multi-task Multi-slice Deep Learning System (M3Lung-Sys) for multi-class lung pneumonia screening from CT imaging, which only consists of two 2D CNN networks, i.e., slice- and patient-level classification networks. The former aims to seek the feature representations from abundant CT slices instead of limited CT volumes, and …
Maulana Azad National Institute of Technology(毛拉纳·阿扎德国家理工学院)
Automatic and rapid screening of COVID-19 from the chest X-ray images has become an urgent need in this pandemic situation of SARS-CoV-2 worldwide in 2020. However, accurate and reliable screening of patients is a massive challenge due to the discrepancy between COVID-19 and other viral pneumonia in X-ray images. In this paper, we design a new stacked convolutional neural network model for the automatic diagnosis of COVID-19 disease from the chest X-ray images. We obtain different sub-models from the VGG19 and developed a 30-layered CNN model (named as CovNet30) during the training, and obtain…
IQVIA(艾昆纬);University of Illinois at Urbana-Champaign(伊利诺伊大学厄巴纳-香槟分校)
To test the possibility of differentiating chest x-ray images of COVID-19 against other pneumonia and healthy patients using deep neural networks. We construct the X-ray imaging data from two publicly available sources, which include 5508 chest x-ray images across 2874 patients with four classes: normal, bacterial pneumonia, non-COVID-19 viral pneumonia, and COVID-19. To identify COVID-19, we propose a Focal Loss Based Neural Ensemble Network (FLANNEL), a flexible module to ensemble several convolutional neural network (CNN) models and fuse with a focal loss for accurate COVID-19 detection on …
NVIDIA(英伟达);National Institute of Health Clinical Center(美国国立卫生研究院临床中心)
Detecting clinically relevant objects in medical images is a challenge despite large datasets due to the lack of detailed labels. To address the label issue, we utilize the scene-level labels with a detection architecture that incorporates natural language information. We present a challenging new set of radiologist paired bounding box and natural language annotations on the publicly available MIMIC-CXR dataset especially focussed on pneumonia and pneumothorax. Along with the dataset, we present a joint vision language weakly supervised transformer layer-selected one-stage dual head detection …
Cupertino High School(库比蒂诺高中);Stanford University(斯坦福大学)
Coronavirus disease 2019 (COVID-19) is the highly contagious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The standard diagnostic testing procedure for COVID-19 is testing a nasopharyngeal swab for SARS-CoV-2 nucleic acid using a real-time polymerase chain reaction (PCR), which can take multiple days to provide a diagnosis. Another widespread form of testing is rapid antigen testing, which has a low sensitivity compared to PCR, but is favored for its quick diagnosis time of usually 15-30 minutes. Patients who test positive for COVID-19 demonstrate diffuse alv…
Around 450 million people are affected by pneumonia every year which results in 2.5 million deaths. Covid-19 has also affected 181 million people which has lead to 3.92 million casualties. The chances of death in both of these diseases can be significantly reduced if they are diagnosed early. However, the current methods of diagnosing pneumonia (complaints + chest X-ray) and covid-19 (RT-PCR) require the presence of expert radiologists and time, respectively. With the help of Deep Learning models, pneumonia and covid-19 can be detected instantly from Chest X-rays or CT scans. This way, the pro…
In 2019, the entire world is facing a situation of health emergency due to a newly emerged coronavirus (COVID-19). Almost 196 countries are affected by covid-19, while USA, Italy, China, Spain, Iran, and France have the maximum active cases of COVID-19. The issues, medical and healthcare departments are facing in delay of detecting the COVID-19. Several artificial intelligence based system are designed for the automatic detection of COVID-19 using chest x-rays. In this article we will discuss the different approaches used for the detection of COVID-19 and the challenges we are facing. It is ma…
Early and accurate diagnosis of COVID-19 is essential to control the rapid spread of the pandemic and mitigate sequelae in the population. Current diagnostic methods, such as RT-PCR, are effective but require time to provide results and can quickly overwhelm clinics, requiring individual laboratory analysis. Automatic detection methods have the potential to significantly reduce diagnostic time. To this end, learning-based methods using lung imaging have been explored. Although they require specialized hardware, automatic evaluation methods can be performed simultaneously, making diagnosis fast…
University of L’Aquila(拉奎拉大学);Sapienza University(罗马大学)
OVID-19 is a world-wide disease that has been declared as a pandemic by the World Health Organization. Computer Tomography (CT) imaging of the chest seems to be a valid diagnosis tool to detect COVID-19 promptly and to control the spread of the disease. Deep Learning has been extensively used in medical imaging and convolutional neural networks (CNNs) have been also used for classification of CT images. We propose a light CNN design based on the model of the SqueezeNet, for the efficient discrimination of COVID-19 CT images with other CT images (community-acquired pneumonia and/or healthy imag…
Advancing Diagnostic Precision: Leveraging Machine Learning Techniques for Accurate Detection of Covid-19, Pneumonia, and Tuberculosis in Chest X-Ray Images
University of Maryland School of Medicine(马里兰大学医学院);Johns Hopkins University(约翰斯·霍普金斯大学)
Chest X-ray (CXR) datasets hosted on Kaggle, though useful from a data science competition standpoint, have limited utility in clinical use because of their narrow focus on diagnosing one specific disease. In real-world clinical use, multiple diseases need to be considered since they can co-exist in the same patient. In this work, we demonstrate how federated learning (FL) can be used to make these toy CXR datasets from Kaggle clinically useful. Specifically, we train a single FL classification model (`global`) using two separate CXR datasets -- one annotated for presence of pneumonia and the …
Shanghai Jiao Tong University(上海交通大学);Shanghai United Imaging Intelligence Co.(上海联影智能有限公司);Huazhong University of Science and Technology(华中科技大学);Tongji Hospital(同济医院);Fudan University(复旦大学);Shanghai Public Health Clinical Center(上海市公共卫生临床中心);Central South University(中南大学);The Second Xiangya Hospital(湘雅二医院);Jilin University(吉林大学);China-Japan Union Hospital of Jilin University(吉林大学中日联谊医院)
The coronavirus disease (COVID-19) is rapidly spreading all over the world, and has infected more than 1,436,000 people in more than 200 countries and territories as of April 9, 2020. Detecting COVID-19 at early stage is essential to deliver proper healthcare to the patients and also to protect the uninfected population. To this end, we develop a dual-sampling attention network to automatically diagnose COVID- 19 from the community acquired pneumonia (CAP) in chest computed tomography (CT). In particular, we propose a novel online attention module with a 3D convolutional network (CNN) to focus…
Elsevier Science Publishers B.V.(爱思唯尔科学出版公司);University of Winchester(温彻斯特大学);Universidad de Granada(格拉纳达大学);Universidad de Malaga(马拉加大学);University of Leicester(莱斯特大学)
Respiratory diseases kill million of people each year. Diagnosis of these pathologies is a manual, time-consuming process that has inter and intra-observer variability, delaying diagnosis and treatment. The recent COVID-19 pandemic has demonstrated the need of developing systems to automatize the diagnosis of pneumonia, whilst Convolutional Neural Network (CNNs) have proved to be an excellent option for the automatic classification of medical images. However, given the need of providing a confidence classification in this context it is crucial to quantify the reliability of the model's predict…
National Cheng Kung University(台湾成功大学);Kun Shan University(昆山科技大学);National Cheng Kung University Hospital(台湾成功大学医院)
In recent years, convolutional neural networks (CNNs) have been successfully implemented to various image recognition applications, such as medical image analysis, object detection, and image segmentation. Many studies and applications have been working on improving the performance of CNN algorithms and models. The strategies that aim to improve the performance of CNNs can be grouped into three major approaches: (1) deeper and wider network architecture, (2) automatic architecture search, and (3) convolutional attention block. Unlike approaches (1) and (2), the convolutional attention block ap…
Universidade Estadual de Maringá(马里兰州立大学);Instituto Federal do Paraná(巴拉那联邦学院);Universidade Tecnológica Federal do Paraná(巴拉那联邦理工大学);Universidade Federal do Paraná(巴拉那联邦大学);Università Degli Studi di Padova(帕多瓦大学);Universidade Federal de Pernambuco(伯南布哥联邦大学)
COVID-19 frequently provokes pneumonia, which can be diagnosed using imaging exams. Chest X-ray (CXR) is often useful because it is cheap, fast, widespread, and uses less radiation. Here, we demonstrate the impact of lung segmentation in COVID-19 identification using CXR images and evaluate which contents of the image influenced the most. Semantic segmentation was performed using a U-Net CNN architecture, and the classification using three CNN architectures (VGG, ResNet, and Inception). Explainable Artificial Intelligence techniques were employed to estimate the impact of segmentation. A three…
Intelligent Medical Image Computing Systems (IMICS) Lab(智能医学影像计算系统实验室);The Hospital for Sick Children(病童医院);University of Toronto(多伦多大学)
COVID-19 spread across the globe at an immense rate has left healthcare systems incapacitated to diagnose and test patients at the needed rate. Studies have shown promising results for detection of COVID-19 from viral bacterial pneumonia in chest X-rays. Automation of COVID-19 testing using medical images can speed up the testing process of patients where health care systems lack sufficient numbers of the reverse-transcription polymerase chain reaction (RT-PCR) tests. Supervised deep learning models such as convolutional neural networks (CNN) need enough labeled data for all classes to correct…
Guilin University of Electronic Technology(桂林电子科技大学);Ecole de technologie Superieure(高等技术学院)
This paper proposes to encode the distribution of features learned from a convolutional neural network using a Gaussian Mixture Model. These parametric features, called GMM-CNN, are derived from chest computed tomography and X-ray scans of patients with Coronavirus Disease 2019. We use the proposed GMM-CNN features as input to a robust classifier based on random forests to differentiate between COVID-19 and other pneumonia cases. Our experiments assess the advantage of GMM-CNN features compared to standard CNN classification on test images. Using a random forest classifier (80\% samples for tr…
University of Manouba(马努巴大学);Taibah University(塔伊巴大学)
By the start of 2020, the novel coronavirus disease (COVID-19) has been declared a worldwide pandemic. Because of the severity of this infectious disease, several kinds of research have focused on combatting its ongoing spread. One potential solution to detect COVID-19 is by analyzing the chest X-ray images using Deep Learning (DL) models. In this context, Convolutional Neural Networks (CNNs) are presented as efficient techniques for early diagnosis. In this study, we propose a novel randomly initialized CNN architecture for the recognition of COVID-19. This network consists of a set of differ…
Institute of Information and Communication Technology, Bangladesh University of Engineering and Technology(孟加拉国工程技术大学信息与通信技术研究所)
Lung disease is common throughout the world. These include chronic obstructive pulmonary disease, pneumonia, asthma, tuberculosis, fibrosis, etc. Timely diagnosis of lung disease is essential. Many image processing and machine learning models have been developed for this purpose. Different forms of existing deep learning techniques including convolutional neural network (CNN), vanilla neural network, visual geometry group based neural network (VGG), and capsule network are applied for lung disease prediction.The basic CNN has poor performance for rotated, tilted, or other abnormal image orient…
Spreading of COVID-19 virus has increased the efforts to provide testing kits. Not only the preparation of these kits had been hard, rare, and expensive but also using them is another issue. Results have shown that these kits take some crucial time to recognize the virus, in addition to the fact that they encounter with 30% loss. In this paper, we have studied the usage of x-ray pictures which are ubiquitous, for the classification of COVID-19 chest Xray images, by the existing convolutional neural networks (CNNs). We intend to train chest x-rays of infected and not infected ones with differen…
Carnegie Mellon University(卡内基梅隆大学);University of Illinois at Urbana-Champaign(伊利诺伊大学厄巴纳-香槟分校);Petuum Inc.(Petuum 公司)
Due to the shortage of COVID-19 viral testing kits and the long waiting time, radiology imaging is used to complement the screening process and triage patients into different risk levels. Deep learning based methods have taken an active role in automatically detecting COVID-19 disease in chest x-ray images, as witnessed in many recent works in early 2020. Most of these works first train a Convolutional Neural Network (CNN) on an existing large-scale chest x-ray image dataset and then fine-tune it with a COVID-19 dataset at a much smaller scale. However, direct transfer across datasets from dif…
Encouraged by the success of deep learning in a variety of domains, we investigate a novel application of its methods on the effectiveness of detecting user confusion in eye-tracking data. We introduce an architecture that uses RNN and CNN sub-models in parallel to take advantage of the temporal and visuospatial aspects of our data. Experiments with a dataset of user interactions with the ValueChart visualization tool show that our model outperforms an existing model based on Random Forests resulting in a 22% improvement in combined sensitivity & specificity.