人类有丝分裂染色体振荡的张力钟控制
Tension-clock control of human mitotic chromosome oscillations
摘要：
在细胞分裂过程中，成对的（姐妹）染色体被观察到在细胞中平面上进行近似的锯齿振荡。实验数据表明，这些振荡通过intersister张力调节。我们提出了一个依赖于时间的张力阈值模型，具有三个稳定的周期解和相图可以产生半解析。扩散噪声的引入再现了真实的振荡，具有真实的周期，振幅，并再现了对姐妹中的任何一个可以首先切换方向的观察。
英文摘要：
During cell division paired (sister) chromosomes are observed to perform approximate saw-tooth oscillations across the cell mid-plane. Experimental data suggests that these oscillations are regulated through intersister tension. We propose a time dependent tension threshold model that exhibits three stable periodic solutions and the phase diagram can be generated semi-analytically. Incorporation of diffusive noise reproduces realistic oscillations, with realistic periods, amplitudes and reproducing the observation that either sister of the pair can switch direction first.
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