细胞微砌块：单细胞精密生物织物
Cellular Micromasonry: Biofabrication with Single Cell Precision
摘要：
在许多组织中，细胞类型在单细胞长度尺度上变化，从而产生对生理功能至关重要的详细空间异质性。为了理解组织功能和详细结构之间的关系，并有朝一日在结构和生理上精确地设计组织，我们需要能够组装具有活组织中发现的细节水平的3D细胞结构。在这里，我们介绍了一种3D细胞组装的方法，它具有比单细胞尺度更精细的精度水平。通过这种方法，我们创建了许多具有明确定义的空间模式的结构，证明细胞类型可以在单个细胞的规模上变化，并在组装后显示功能。这项技术提供了无数的机会，研究细胞行为在定义的背景下，包括复杂的相互作用，在胚胎发生过程中操作。
英文摘要：
In many tissues, cell type varies over single-cell length-scales, creating detailed spatial heterogeneities fundamental to physiological function. To gain understanding of this relationship between tissue function and detailed structure, and to one day engineer structurally and physiologically accurate tissues, we need the ability to assemble 3D cellular structures having the level of detail found in living tissue. Here we introduce a method of 3D cell assembly that has a level of precision finer than the single-cell scale. With this method we create numerous structures having well-defined spatial patterns, demonstrating that cell type can be varied over the scale of individual cells and showing function after their assembly. This technique provides innumerable opportunities to study cellular behavior in defined contexts including complex interactions operating during embryogenesis.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
