The mechanical properties of tissues play an essential role for all tissue properties such as cell division, and differentiation or morphogenesis. Here, we study theoretically the rheology of 2-dimensional epithelial tissues described by a discrete vertex-like model, using an analytical coarsegrained continuum formulation. We show that epithelial tissues are most often shear-thinning under constant shear rate, and in certain circumstances cross over from shear thickening at low shear rates to shear thinning at high shear rates. We give an analytical expression of the tissue response in an oscillating strain experiment in the linear regime, and calculate it numerically in the non-linear regime. When the tissue is supported by an oscillating substrate, it reorients depending on frequency and substrate's Poisson's ratio. Reorientation could be gradual or abrupt, depending on tissue and substrate parameters, and the configuration phase space exhibits a tricritical point.
Cell bulging and extrusion in a three-dimensional bubbly vertex model for curved epithelial sheets
Institute for Theoretical Physics, Heidelberg University(海德堡大学理论物理研究所);BioQuant, Heidelberg University(海德堡大学生物定量研究中心);Max Planck School Matter to Life, Heidelberg University(海德堡大学马克斯·普朗克生命物质学院);Institute of Science and Technology Austria(奥地利科学技术研究所);Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ)(德国癌症研究中心信号与功能基因组学部);Department of Molecular Human Genetics, Medical Faculty Heidelberg, Heidelberg University(海德堡大学医学院分子人类遗传学系)
Non-linear visco-elasto-plastic rheology of a viscous vertex model
Aix Marseille Univ, Université de Toulon, CNRS, CPT (UMR 7332), Turing Centre for Living systems(艾克斯-马赛大学,土伦大学,法国国家科学研究中心,理论物理与粒子物理中心(UMR 7332),图灵生命系统中心);Institut für Theoretische Physik, Universität Innsbruck(因斯布鲁克大学理论物理研究所)
Discontinuous buckling from cytoplasmic mechanics in vertex models of epithelia
Max Planck Institute for the Physics of Complex Systems(马克斯·普朗克复杂系统物理研究所);Max Planck Institute of Molecular Cell Biology and Genetics(马克斯·普朗克分子细胞生物学与遗传学研究所);Center for Systems Biology Dresden(德累斯顿系统生物学中心)
Noninvasive rheological inference from stable flows in confined tissues
Aix Marseille Univ, Université de Toulon, CNRS, CPT (UMR 7332), Turing Centre for Living Systems(艾克斯马赛大学,土伦大学,法国国家科学研究中心,CPT(UMR 7332),图灵生命系统中心);Université Paris Cité, CNRS, Institut Jacques Monod(巴黎西岱大学,法国国家科学研究中心,雅克·莫诺研究所);Friedrich-Alexander Universität Erlangen-Nürnberg(埃尔朗根-纽伦堡弗里德里希·亚历山大大学);Max-Planck-Zentrum für Physik und Medizin(马克斯·普朗克物理与医学中心);Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices, School of Physics, Sun Yat-sen University(广东磁电物理与器件重点实验室,中山大学物理学院);Centre for Physical Mechanics and Biophysics, School of Physics, Sun Yat-sen University(物理力学与生物物理中心,中山大学物理学院);Aix Marseille Univ, IBDM (UMR 7288), Turing Centre for Living Systems(艾克斯马赛大学,IBDM(UMR 7288),图灵生命系统中心);Aix Marseille Univ, Université de Toulon, CNRS, LAI (UMR 7333), Turing Centre for Living Systems(艾克斯马赛大学,土伦大学,法国国家科学研究中心,LAI(UMR 7333),图灵生命系统中心)
Shape-tension coupling produces nematic order in an epithelium vertex model
Rudolf Peierls Centre For Theoretical Physics, University of Oxford(鲁道夫·派尔斯理论物理中心,牛津大学);School of Science and Engineering, University of Dundee(邓迪大学科学与工程学部);School of Life Sciences, University of Dundee(邓迪大学生命科学学部)
Adhesion differentials control the rheology of biomimetic emulsions
Sorbonne Université(索邦大学);CNRS(法国国家科学研究中心);Laboratoire Jean Perrin(让·佩兰实验室);Inserm(法国国家健康与医学研究院);Institut de Biologie Paris-Seine(巴黎塞纳生物学研究所);Aix Marseille Univ(艾克斯-马赛大学);Université de Toulon(土伦大学);CPT (UMR 7332)(复杂系统物理中心(UMR 7332));Turing Center for Living Systems(图灵生命系统中心)