Background: The clinical utility of late gadolinium enhancement (LGE) cardiac MRI is limited by the lack of standardization, and time-consuming postprocessing. In this work, we tested the hypothesis that a cascaded deep learning pipeline trained with augmentation by synthetically generated data would improve model accuracy and robustness for automated scar quantification.
Methods: A cascaded pipeline consisting of three consecutive neural networks is proposed, starting with a bounding box regression network to identify a region of interest around the left ventricular (LV) myocardium. Two further nnU-Net models are then used to segment the myocardium and, if present, scar. The models were trained on the data from the EMIDEC challenge, supplemented with an extensive synthetic dataset generated with a conditional GAN.
Results: The cascaded pipeline significantly outperformed a single nnU-Net directly segmenting both the myocardium (mean Dice similarity coefficient (DSC) (standard deviation (SD)): 0.84 (0.09) vs 0.63 (0.20), p < 0.01) and scar (DSC: 0.72 (0.34) vs 0.46 (0.39), p < 0.01) on a per-slice level. The inclusion of the synthetic data as data augmentation during training improved the scar segmentation DSC by 0.06 (p < 0.01). The mean DSC per-subject on the challenge test set, for the cascaded pipeline augmented by synthetic generated data, was 0.86 (0.03) and 0.67 (0.29) for myocardium and scar, respectively.
Conclusion: A cascaded deep learning-based pipeline trained with augmentation by synthetically generated data leads to myocardium and scar segmentations that are similar to the manual operator, and outperforms direct segmentation without the synthetic images.
Universitat de Barcelona（巴塞罗那大学）；Barts Health NHS Trust（巴特兹健康国民保健服务信托基金）；Queen Mary University of London（伦敦玛丽女王大学）；Universitat Pompeu Fabra（庞培法布拉大学）；ICREA（加泰罗尼亚研究与高级研究院）
Accurate segmentation of the cardiac boundaries in late gadolinium enhancement magnetic resonance images (LGE-MRI) is a fundamental step for accurate quantification of scar tissue. However, while there are many solutions for automatic cardiac segmentation of cine images, the presence of scar tissue can make the correct delineation of the myocardium in LGE-MRI challenging even for human experts. As part of the Multi-Sequence Cardiac MR Segmentation Challenge, we propose a solution for LGE-MRI segmentation based on two components. First, a generative adversarial network is trained for the task o…
TAI-GAN: A Temporally and Anatomically Informed Generative Adversarial Network for early-to-late frame conversion in dynamic cardiac PET inter-frame motion correction
Yale University（耶鲁大学）；IBM Research（IBM研究院）；Yale New Haven Hospital（耶鲁-纽黑文医院）；Yale School of Medicine（耶鲁医学院）
Synthesis of Late Gadolinium Enhancement Images via Implicit Neural Representations for Cardiac Scar Segmentation
Amsterdam UMC, The Netherlands（阿姆斯特丹大学医学中心，荷兰）；University of Amsterdam, The Netherlands（阿姆斯特丹大学，荷兰）；Informatics Institute, University of Amsterdam, The Netherlands（阿姆斯特丹大学信息学院，荷兰）；Amsterdam Cardiovascular Sciences, Amsterdam UMC, The Netherlands（阿姆斯特丹心血管科学，阿姆斯特丹大学医学中心，荷兰）；Amsterdam Machine Learning Lab, University of Amsterdam, The Netherlands（阿姆斯特丹机器学习实验室，阿姆斯特丹大学，荷兰）；Department of Biomedical Engineering and Physics, Amsterdam UMC, The Netherlands（生物医学工程与物理系，阿姆斯特丹大学医学中心，荷兰）；Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC, The Netherlands（实验心脏病学系，阿姆斯特丹心血管科学，心力衰竭与心律失常，阿姆斯特丹大学医学中心，荷兰）；Department of Cardiology, Amsterdam UMC, The Netherlands（心脏病学系，阿姆斯特丹大学医学中心，荷兰）；Department of Radiology and Nuclear Medicine, Amsterdam UMC, The Netherlands（放射学与核医学系，阿姆斯特丹大学医学中心，荷兰）；Department of Radiology, Mayo Clinic, Rochester, United States of America（放射学系，梅奥诊所，罗切斯特，美国）
Temporally Consistent and Controllable Video Generation of 2D Cine CMR via Latent Space Motion Modeling
Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences（苏州生物医学工程与技术研究所，中国科学院）；SyCoIA, IMT Mines Ales（SyCoIA，IMT Mines Ales）
Friedrich-Alexander-University Erlangen-Nuremberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）；University of Leeds（利兹大学）
Quantitative assessment of cardiac left ventricle (LV) morphology is essential to assess cardiac function and improve the diagnosis of different cardiovascular diseases. In current clinical practice, LV quantification depends on the measurement of myocardial shape indices, which is usually achieved by manual contouring of the endo- and epicardial. However, this process subjected to inter and intra-observer variability, and it is a time-consuming and tedious task. In this paper, we propose a spatio-temporal multi-task learning approach to obtain a complete set of measurements quantifying cardia…
3D Cardiac Anatomy Generation Using Mesh Latent Diffusion Models
Department of Computer Science, University of Oxford（计算机科学系，牛津大学）；Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford（生物医学工程研究所，工程科学系，牛津大学）；Visual Geometry Group, Department of Engineering Science, University of Oxford（视觉几何组，工程科学系，牛津大学）；Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford（心血管医学部，拉德克利夫医学系，牛津大学）
Cardiac left ventricle (LV) quantification provides a tool for diagnosing cardiac diseases. Automatic calculation of all relevant LV indices from cardiac MR images is an intricate task due to large variations among patients and deformation during the cardiac cycle. Typical methods are based on segmentation of the myocardium or direct regression from MR images. To consider cardiac motion and deformation, recurrent neural networks and spatio-temporal convolutional neural networks (CNNs) have been proposed. We study an approach combining state-of-the-art models and emphasizing transfer learning t…
Uncertainty Quantification for Cardiac Shape Reconstruction with Deep Signed Distance Functions via MCMC methods
Department of Mathematics and Scientific Computing, University of Graz, Austria（格拉茨大学数学与科学计算系，奥地利）；PRIN-PNRR project no. P2022N5ZNP（PRIN-PNRR项目编号P2022N5ZNP）；INdAM-GNCS
Sun Yat-sen University（中山大学）；Royal Brompton Hospital（皇家布朗普顿医院）；Imperial College London（帝国理工学院）
Automated and accurate segmentations of left atrium (LA) and atrial scars from late gadolinium-enhanced cardiac magnetic resonance (LGE CMR) images are in high demand for quantifying atrial scars. The previous quantification of atrial scars relies on a two-phase segmentation for LA and atrial scars due to their large volume difference (unbalanced atrial targets). In this paper, we propose an inter-cascade generative adversarial network, namely JAS-GAN, to segment the unbalanced atrial targets from LGE CMR images automatically and accurately in an end-to-end way. Firstly, JAS-GAN investigates a…
University of Virginia（弗吉尼亚大学）；University of Virginia Health System（弗吉尼亚大学卫生系统）
Automated identification of myocardial scar from late gadolinium enhancement cardiac magnetic resonance images (LGE-CMR) is limited by image noise and artifacts such as those related to motion and partial volume effect. This paper presents a novel joint deep learning (JDL) framework that improves such tasks by utilizing simultaneously learned myocardium segmentations to eliminate negative effects from non-region-of-interest areas. In contrast to previous approaches treating scar detection and myocardium segmentation as separate or parallel tasks, our proposed method introduces a message passin…
Imperial College London（帝国理工学院）；Royal Brompton Hospital（皇家布朗普顿医院）
Segmentation of cardiac fibrosis and scar are essential for clinical diagnosis and can provide invaluable guidance for the treatment of cardiac diseases. Late Gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) has been successful for its efficacy in guiding the clinical diagnosis and treatment reliably. For LGE CMR, many methods have demonstrated success in accurately segmenting scarring regions. Co-registration with other non-contrast-agent (non-CA) modalities, balanced steady-state free precession (bSSFP) and cine magnetic resonance imaging (MRI) for example, can further en…
Johns Hopkins University School of Medicine（约翰斯·霍普金斯大学医学院）；Johns Hopkins University（约翰斯·霍普金斯大学）；Johns Hopkins Hospital（约翰斯·霍普金斯医院）
Visualizing disease-induced scarring and fibrosis in the heart on cardiac magnetic resonance (CMR) imaging with contrast enhancement (LGE) is paramount in characterizing disease progression and quantifying pathophysiological substrates of arrhythmias. However, segmentation and scar/fibrosis identification from LGE-CMR is an intensive manual process prone to large inter-observer variability. Here, we present a novel fully-automated anatomically-informed deep learning solution for left ventricle (LV) and scar/fibrosis segmentation and clinical feature extraction from LGE-CMR. The technology invo…
Universidade Federal Fluminense (UFF)（弗鲁米嫩塞联邦大学）；Universidade Federal do Rio de Janeiro (UFRJ)（里约热内卢联邦大学）；Universidade Federal do Espírito Santo (UFES)（圣埃斯皮里图联邦大学）
The deposits of fat on the surroundings of the heart are correlated to several health risk factors such as atherosclerosis, carotid stiffness, coronary artery calcification, atrial fibrillation and many others. These deposits vary unrelated to obesity, which reinforces its direct segmentation for further quantification. However, manual segmentation of these fats has not been widely deployed in clinical practice due to the required human workload and consequential high cost of physicians and technicians. In this work, we propose a unified method for an autonomous segmentation and quantification…
National Heart and Lung Institute, Imperial College London（帝国理工学院国家心肺研究所）；Royal Brompton Hospital（皇家布朗普顿医院）；University of the Basque Country UPV/EHU（巴斯克大学）；TECNALIA, Basque Research and Technology Alliance（巴斯克研究与技术联盟TECNALIA）；Beihang University（北京航空航天大学）；Shenzhen Second People’s Hospital（深圳市第二人民医院）
Synthetic digital twins based on medical data accelerate the acquisition, labelling and decision making procedure in digital healthcare. A core part of digital healthcare twins is model-based data synthesis, which permits the generation of realistic medical signals without requiring to cope with the modelling complexity of anatomical and biochemical phenomena producing them in reality. Unfortunately, algorithms for cardiac data synthesis have been so far scarcely studied in the literature. An important imaging modality in the cardiac examination is three-directional CINE multi-slice myocardial…
Balancing Fidelity, Utility, and Privacy in Synthetic Cardiac MRI Generation: A Comparative Study
University of Peradeniya, Sri Lanka（斯里兰卡大学）；University of Maryland, College Park, USA（美国马里兰大学 College Park 分校）；Tulane University School of Medicine, USA（美国 Tulane 大学医学院）；Simula Research Laboratory, Norway（挪威 Simula 研究实验室）；SimulaMet, Norway（挪威 SimulaMet）
Can Diffusion Models Bridge the Domain Gap in Cardiac MR Imaging?
Centre for Doctoral Training in AI for Medical Diagnosis and Care（人工智能医学诊断与护理博士培训中心）；School of Computing, University of Leeds（莱斯特大学计算机学院）；Leeds Cancer Centre, St James’s University Hospital, Leeds, UK（利兹癌症中心，圣詹姆斯大学医院，利兹，英国）
Fairness-Aware Data Augmentation for Cardiac MRI using Text-Conditioned Diffusion Models
Barcelona Artificial Intelligence in Medicine Lab (BCN-AIM)（巴塞罗那人工智能在医学实验室（BCN-AIM））；Departament de Matemàtiques i Informàtica, Universitat de Barcelona, Spain（数学与计算机科学系，巴塞罗那大学，西班牙）；Helmholtz Center Munich（海德堡研究中心慕尼黑）；Technical University of Munich（慕尼黑技术大学）；William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, Charterhouse Square, London, UK（威廉·哈维研究所，英国国家健康研究院巴特研究所，伦敦女王玛丽大学，查尔斯广场，伦敦，英国）；Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London, UK（巴特心脏中心，圣巴塞洛缪医院，巴特健康国家卫生信托，西史密斯菲尔德，伦敦，英国）；Institució Catalana de Recerca i Estudis Avançats (ICREA)（加泰罗尼亚高级研究与教育研究所（ICREA））
Synthetic Cardiac MRI Image Generation using Deep Generative Models
Department of Computer Engineering（计算机工程系）；University of Peradeniya（珀德尼亚大学）；University of Maryland（马里兰大学）；Department of Holistic Systems（整体系统系）；SimulaMet；Oslo, Norway（挪威奥斯陆）
CONICET（阿根廷国家科学与技术研究理事会）；The Bariloche Atomic Center（巴里洛切原子中心）；Instituto Balseiro（巴尔塞罗研究所）；Universidad Nacional de Cuyo（库约国立大学）；Sanatorio San Carlos（圣卡洛斯疗养院）；National Atomic Energy Commission (Comisión Nacional de Energía Atómica, CNEA)（国家原子能委员会（CNEA））
Background: Artificial intelligence techniques have shown great potential in cardiology, especially in quantifying cardiac biventricular function, volume, mass, and ejection fraction (EF). However, its use in clinical practice is not straightforward due to its poor reproducibility with cases from daily practice, among other reasons. Objectives: To validate a new artificial intelligence tool in order to quantify the cardiac biventricular function (volume, mass, and EF). To analyze its robustness in the clinical area, and the computational times compared with conventional methods. Methods: A tot…
DECADE: A Temporally-Consistent Unsupervised Diffusion Model for Enhanced Rb-82 Dynamic Cardiac PET Image Denoising
Yale University（耶鲁大学）；Yale School of Medicine（耶鲁医学院）；Siemens Medical Solutions USA, Inc.（西门子医疗解决方案美国公司）；Inselspital, Bern University Hospital（伯尔尼大学医院Inselspital）；University of Bern（伯尔尼大学）；Department of Biomedical Engineering（生物医学工程系）；Department of Radiology and Biomedical Imaging（放射科和生物医学成像系）；Department of Medicine (Cardiology)（医学系（心脏病学））
Contrast-Free Myocardial Scar Segmentation in Cine MRI using Motion and Texture Fusion
University of Oxford（牛津大学）；University of Southampton（南安普顿大学）；National University of Singapore（新加坡国立大学）；Fudan University（复旦大学）；Zhongshan Hospital, Fudan University（复旦大学附属中山医院）
National University of Singapore（新加坡国立大学）；National University Heart Centre（国立大学心脏中心）；National University Hospital（国立大学医院）
Late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) can directly visualize nonviable myocardium with hyperenhanced intensities with respect to normal myocardium. For heart attack patients, it is crucial to facilitate the decision of appropriate therapy by analyzing and quantifying their LGE CMR images. To achieve accurate quantification, LGE CMR images need to be processed in two steps: segmentation of the myocardium followed by classification of infarcts within the segmented myocardium. However, automatic segmentation is difficult usually due to the intensity heterogeneity of the …
In real-time (RT) cardiac cine imaging, a stack of 2D slices is collected sequentially under free-breathing conditions. A complete heartbeat from each slice is then used for cardiac function quantification. The inter-slice respiratory mismatch can compromise accurate quantification of cardiac function. Methods based on principal components analysis (PCA) have been proposed to extract the respiratory signal from RT cardiac cine, but these methods cannot resolve the inter-slice sign ambiguity of the respiratory signal. In this work, we propose a fully automatic sign correction procedure based on…
Fudan University（复旦大学）；Shanghai Jiao Tong University（上海交通大学）；King’s College London（伦敦国王学院）；Technical University Munich（慕尼黑工业大学）；Helmholtz Center Munich（慕尼黑亥姆霍兹中心）
Left atrial (LA) and atrial scar segmentation from late gadolinium enhanced magnetic resonance imaging (LGE MRI) is an important task in clinical practice. %, to guide ablation therapy and predict treatment results for atrial fibrillation (AF) patients. The automatic segmentation is however still challenging, due to the poor image quality, the various LA shapes, the thin wall, and the surrounding enhanced regions. Previous methods normally solved the two tasks independently and ignored the intrinsic spatial relationship between LA and scars. In this work, we develop a new framework, namely Atr…
We propose an end-to-end deep neural network (DNN) which can simultaneously segment the left atrial (LA) cavity and quantify LA scars. The framework incorporates the continuous spatial information of the target by introducing a spatially encoded (SE) loss based on the distance transform map. Compared to conventional binary label based loss, the proposed SE loss can reduce noisy patches in the resulting segmentation, which is commonly seen for deep learning-based methods. To fully utilize the inherent spatial relationship between LA and LA scars, we further propose a shape attention (SA) mechan…
ScarNet: A Novel Foundation Model for Automated Myocardial Scar Quantification from LGE in Cardiac MRI
Northwestern University（西北大学）；Feinberg School of Medicine（费林伯格医学院）；University of Miami Miller School of Medicine（迈阿密大学米勒医学院）；Cedars-Sinai Medical Center（西达赛奈医疗中心）
ProDM: Synthetic Reality-driven Property-aware Progressive Diffusion Model for Coronary Calcium Motion Correction in Non-gated Chest CT
Department of Radiology, Northwestern University, Chicago, IL, USA；College of Computing, Georgia Institute of Technology, Atlanta, GA, USA；Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA；Department of Cardiology, Northwestern University, Chicago, IL, USA；Department of Preventive Medicine, Northwestern University, Chicago, IL, USA
Southeast University（东南大学）；Shenzhen University（深圳大学）；Fudan University（复旦大学）；Shanghai Jiao Tong University（上海交通大学）；Kings College London（伦敦国王学院）；Affiliated Drum Tower Hospital of Nanjing University Medical School（南京大学医学院附属鼓楼医院）
Multi-sequence cardiac magnetic resonance (CMR) provides essential pathology information (scar and edema) to diagnose myocardial infarction. However, automatic pathology segmentation can be challenging due to the difficulty of effectively exploring the underlying information from the multi-sequence CMR data. This paper aims to tackle the scar and edema segmentation from multi-sequence CMR with a novel auto-weighted supervision framework, where the interactions among different supervised layers are explored under a task-specific objective using reinforcement learning. Furthermore, we design a c…
Background: Increased pericardial adipose tissue (PAT) is associated with many types of cardiovascular disease (CVD). Although cardiac magnetic resonance images (CMRI) are often acquired in patients with CVD, there are currently no tools to automatically identify and quantify PAT from CMRI. The aim of this study was to create a neural network to segment PAT from T2-weighted CMRI and explore the correlations between PAT volumes (PATV) and CVD outcomes and mortality. Methods: We trained and tested a deep learning model, PAT-CNN, to segment PAT on T2-weighted cardiac MR images. Using the segmenta…
King's College London（伦敦国王学院）；Eindhoven University of Technology（埃因霍温理工大学）
Cine cardiac magnetic resonance (CMR) has become the gold standard for the non-invasive evaluation of cardiac function. In particular, it allows the accurate quantification of functional parameters including the chamber volumes and ejection fraction. Deep learning has shown the potential to automate the requisite cardiac structure segmentation. However, the lack of robustness of deep learning models has hindered their widespread clinical adoption. Due to differences in the data characteristics, neural networks trained on data from a specific scanner are not guaranteed to generalise well to dat…
LA-CaRe-CNN: Cascading Refinement CNN for Left Atrial Scar Segmentation
Gottfried Schatz Research Center: Medical Physics and Biophysics（戈特弗里德·施蔡茨研究所以及生物物理学）；Medical University of Graz（格拉茨医科大学）；Institute of Computer Graphics and Vision（计算机图形学与视觉研究所）；Graz University of Technology（格拉茨理工大学）；AVL List GmbH；Institute for Medical Informatics, Statistics and Documentation（医学信息学、统计学与文档研究所）
University of Virginia（弗吉尼亚大学）；University of Virginia Health System（弗吉尼亚大学卫生系统）
The selection of an optimal pacing site, which is ideally scar-free and late activated, is critical to the response of cardiac resynchronization therapy (CRT). Despite the success of current approaches formulating the detection of such late mechanical activation (LMA) regions as a problem of activation time regression, their accuracy remains unsatisfactory, particularly in cases where myocardial scar exists. To address this issue, this paper introduces a multi-task deep learning framework that simultaneously estimates LMA amount and classify the scar-free LMA regions based on cine displacement…
Institute of Computing, Universidade Federal Fluminense (UFF)（弗鲁米嫩塞联邦大学计算研究所）；School of Medicine, Universidade Federal do Rio de Janeiro (UFRJ)（里约热内卢联邦大学医学院）
The quantification of fat depots on the surroundings of the heart is an accurate procedure for evaluating health risk factors correlated with several diseases. However, this type of evaluation is not widely employed in clinical practice due to the required human workload. This work proposes a novel technique for the automatic segmentation of cardiac fat pads. The technique is based on applying classification algorithms to the segmentation of cardiac CT images. Furthermore, we extensively evaluate the performance of several algorithms on this task and discuss which provided better predictive mo…
National Heart & Lung Institute, Imperial College London（伦敦帝国理工学院国家心肺研究所）；Royal Brompton Hospital（皇家布朗普顿医院）
Four-dimensional (4D) left ventricular myocardial velocity mapping (MVM) is a cardiac magnetic resonance (CMR) technique that allows assessment of cardiac motion in three orthogonal directions. Accurate and reproducible delineation of the myocardium is crucial for accurate analysis of peak systolic and diastolic myocardial velocities. In addition to the conventionally available magnitude CMR data, 4D MVM also acquires three velocity-encoded phase datasets which are used to generate velocity maps. These can be used to facilitate and improve myocardial delineation. Based on the success of deep l…
University of Alberta（阿尔伯塔大学）；Mazankowski Alberta Heart Institute（马赞科夫斯基阿尔伯塔心脏研究所）
Myocardial characterization is essential for patients with myocardial infarction and other myocardial diseases, and the assessment is often performed using cardiac magnetic resonance (CMR) sequences. In this study, we propose a fully automated approach using deep convolutional neural networks (CNN) for cardiac pathology segmentation, including left ventricular (LV) blood pool, right ventricular blood pool, LV normal myocardium, LV myocardial edema (ME) and LV myocardial scars (MS). The input to the network consists of three CMR sequences, namely, late gadolinium enhancement (LGE), T2 and balan…
Spatial-temporal V-Net for automatic segmentation and quantification of right ventricles in gated myocardial perfusion SPECT images
Michigan Technological University（密歇根理工大学）；Hai’an People’s Hospital（海安市人民医院）；Rush Medical College（拉什医学院）；Cook County Health（库克县医疗系统）；The First Affiliated Hospital of Nanjing Medical University（南京医科大学第一附属医院）；Xi’an University of Posts and Telecommunications（西安邮电大学）
BAAI Cardiac Agent: An intelligent multimodal agent for automated reasoning and diagnosis of cardiovascular diseases from cardiac magnetic resonance imaging
Beijing Academy of Artificial Intelligence（北京智源人工智能研究院）；Department of Radiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung & Vascular Diseases, Capital Medical University（首都医科大学附属北京安贞医院放射科，北京市心肺血管疾病研究所）；Department of MR, the First Affiliated Hospital, Henan Medical University（河南医科大学第一附属医院磁共振科）；Department of Cardiology, Clinical Center for Coronary Heart Disease, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing Anzhen Hospital, Capital Medical University（首都医科大学附属北京安贞医院心内科，冠心病临床中心，北京市心肺血管疾病研究所）；Department of Cardiac Surgery, Beijing Anzhen Hospital, Institute of Heart, Lung and Vascular Diseases, Capital Medical University（首都医科大学附属北京安贞医院心脏外科，心肺血管疾病研究所）
The Chinese University of Hong Kong（香港中文大学）；Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Stanford University（斯坦福大学）
Annotation scarcity is a long-standing problem in medical image analysis area. To efficiently leverage limited annotations, abundant unlabeled data are additionally exploited in semi-supervised learning, while well-established cross-modality data are investigated in domain adaptation. In this paper, we aim to explore the feasibility of concurrently leveraging both unlabeled data and cross-modality data for annotation-efficient cardiac segmentation. To this end, we propose a cutting-edge semi-supervised domain adaptation framework, namely Dual-Teacher++. Besides directly learning from limited l…
UltraTwin: Towards Cardiac Anatomical Twin Generation from Multi-view 2D Ultrasound
National-Regional Key Technology Engineering Laboratory for Medical Ultrasound（医学超声关键技术研发实验室）；School of Biomedical Engineering, Medical School, Shenzhen University（生物医学工程学院）；Faculty of Applied Sciences, Macao Polytechnic University（应用科学学院）；Centre for CIMIM, Manchester University（CIMIM研究中心）；Center for Cardiovascular Disease（心血管疾病中心）；The Affiliated Suzhou Hospital of Nanjing Medical University（南京医科大学附属苏州医院）；Suzhou Municipal Hospital, Gusu School, Suzhou, China（苏州 municipal 医院）；The First Affiliated Hospital of Kunming Medical University（昆明医科大学第一附属医院）；The First Affiliated Hospital of Anhui Medical University North（安徽医科大学北院）；The Second People’s Hospital（第二人民医院）；The First Affiliated Hospital of Anhui Medical University（安徽医科大学第一附属医院）；The People's Hospital of Tongren City（铜仁市人民医院）；The First People's Hospital of Taicang City（太仓市第一人民医院）；Guangdong Provincial People’s Hospital（广东省人民医院）
University of Iowa（爱荷华大学）；Philips HealthCare（飞利浦医疗）；University of Wisconsin（威斯康星大学）；GE HealthCare（通用电气医疗）
Free-breathing cardiac MRI schemes are emerging as competitive alternatives to breath-held cine MRI protocols, enabling applicability to pediatric and other population groups that cannot hold their breath. Because the data from the slices are acquired sequentially, the cardiac/respiratory motion patterns may be different for each slice; current free-breathing approaches perform independent recovery of each slice. In addition to not being able to exploit the inter-slice redundancies, manual intervention or sophisticated post-processing methods are needed to align the images post-recovery for qu…
King’s College London（伦敦国王学院）；Guy’s and St Thomas’ NHS Foundation Trust（盖伊和圣托马斯国民保健服务基金会信托）；ETH Zürich（苏黎世联邦理工学院）；Imperial College London（伦敦帝国理工学院）
Tissue characterisation with CMR parametric mapping has the potential to detect and quantify both focal and diffuse alterations in myocardial structure not assessable by late gadolinium enhancement. Native T1 mapping in particular has shown promise as a useful biomarker to support diagnostic, therapeutic and prognostic decision-making in ischaemic and non-ischaemic cardiomyopathies. Convolutional neural networks with Bayesian inference are a category of artificial neural networks which model the uncertainty of the network output. This study presents an automated framework for tissue characteri…
Echocardiography (echo) is a common means of evaluating cardiac conditions. Due to the label scarcity, semi-supervised paradigms in automated echo analysis are getting traction. One of the most sought-after problems in echo is the segmentation of cardiac structures (e.g. chambers). Accordingly, we propose an echocardiogram generation approach using generative adversarial networks with a conditional patch-based discriminator. In this work, we validate the feasibility of GAN-enhanced echo generation with different conditions (segmentation masks), namely, the left ventricle, ventricular myocardiu…
Scientific Computing and Imaging Institute（科学计算与成像研究所）；University of Utah（犹他大学）；School of Computing（计算学院）
Clinical investigations of anatomy's structural changes over time could greatly benefit from population-level quantification of shape, or spatiotemporal statistic shape modeling (SSM). Such a tool enables characterizing patient organ cycles or disease progression in relation to a cohort of interest. Constructing shape models requires establishing a quantitative shape representation (e.g., corresponding landmarks). Particle-based shape modeling (PSM) is a data-driven SSM approach that captures population-level shape variations by optimizing landmark placement. However, it assumes cross-sectiona…
University of Auckland（奥克兰大学）；Johns Hopkins Medical Center（约翰斯·霍普金斯医疗中心）；University of Wisconsin School of Medicine and Public Health（威斯康星大学医学与公共卫生学院）；Aalborg University（奥尔堡大学）；Auckland Bioengineering Institute（奥克兰生物工程研究所）；Eindhoven University of Technology（埃因霍温理工大学）
The shape and motion of the heart provide essential clues to understanding the mechanisms of cardiovascular disease. With the advent of large-scale cardiac imaging data, statistical atlases become a powerful tool to provide automated and precise quantification of the status of patient-specific heart geometry with respect to reference populations. The Multi-Ethnic Study of Atherosclerosis (MESA), begun in 2000, was the first large cohort study to incorporate cardiovascular MRI in over 5000 participants, and there is now a wealth of follow-up data over 20 years. Building a machine learning based…
Mannheim University of Applied Science（曼海姆应用科技大学）；UT Southwestern Medical Center（德克萨斯大学西南医学中心）；DZHK (German Centre for Cardiovascular Research)（德国心血管研究中心）；German Heart Centre Munich（慕尼黑德国心脏中心）；Hannover Medical School（汉诺威医学院）；Heidelberg University Hospital（海德堡大学医院）
Planning the optimal time of intervention for pulmonary valve replacement surgery in patients with the congenital heart disease Tetralogy of Fallot (TOF) is mainly based on ventricular volume and function according to current guidelines. Both of these two biomarkers are most reliably assessed by segmentation of 3D cardiac magnetic resonance (CMR) images. In several grand challenges in the last years, U-Net architectures have shown impressive results on the provided data. However, in clinical practice, data sets are more diverse considering individual pathologies and image properties derived fr…
Friedrich-Alexander University（弗里德里希-亚历山大大学）；Siemens Healthineers（西门子医疗）；Johns Hopkins University School of Medicine（约翰·霍普金斯大学医学院）
Electroanatomic mapping as routinely acquired in ablation therapy of ventricular tachycardia is the gold standard method to identify the arrhythmogenic substrate. To reduce the acquisition time and still provide maps with high spatial resolution, we propose a novel deep learning method based on graph convolutional neural networks to estimate the depolarization time in the myocardium, given sparse catheter data on the left ventricular endocardium, ECG, and magnetic resonance images. The training set consists of data produced by a computational model of cardiac electrophysiology on a large cohor…
