用于金刚石量子传感器的生物相容表面功能化结构
Biocompatible surface functionalization architecture for a diamond quantum sensor
摘要：
量子精密测量使一些最精确的测量成为可能。在生命科学中，基于金刚石的量子传感已经成为一类新的生物物理传感器和诊断设备，正在研究作为癌症筛查和超灵敏免疫测定的平台。然而，基于纳米级核磁共振光谱学的生命科学中的更广泛的应用受到了阻碍，因为需要将高灵敏度的量子位（qubit）传感器与其生物目标进行接口。在这里，我们展示了一种新的方法，该方法将量子工程与单分子生物物理学相结合，将单个蛋白质和DNA分子固定在大块金刚石晶体的表面上，该晶体具有相干的氮空位量子比特传感器。我们的薄（低于5 nm）功能化架构提供了对蛋白质吸附密度的精确控制，并导致近表面量子位相干性接近100 μs。开发的架构在生理条件下保持化学稳定超过五天，使我们的技术与大多数生物物理和生物医学应用兼容。
英文摘要：
Quantum metrology enables some of the most precise measurements. In the life sciences, diamond-based quantum sensing has enabled a new class of biophysical sensors and diagnostic devices that are being investigated as a platform for cancer screening and ultra-sensitive immunoassays. However, a broader application in the life sciences based on nanoscale nuclear magnetic resonance spectroscopy has been hampered by the need to interface highly sensitive quantum bit (qubit) sensors with their biological targets. Here, we demonstrate a new approach that combines quantum engineering with single-molecule biophysics to immobilize individual proteins and DNA molecules on the surface of a bulk diamond crystal that hosts coherent nitrogen vacancy qubit sensors. Our thin (sub-5 nm) functionalization architecture provides precise control over protein adsorption density and results in near-surface qubit coherence approaching 100 μs. The developed architecture remains chemically stable under physiological conditions for over five days, making our technique compatible with most biophysical and biomedical applications.
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