发表机构
Indian Institute of Technology Bombay（印度理工学院孟买分校）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
该综述展望了量子光学传感从固态自旋缺陷平台向生物集成系统的转变，介绍了相关技术进展、生物相容性改进及应用挑战，为生物医学量子传感发展提供视角。
AI 中文摘要
量子光学传感已从孤立的固态自旋缺陷平台发展为日益面向生物医学应用的生物集成系统。本综述对这一转变进行了展望，涵盖了金刚石中的氮空位（NV）中心到新兴的基于荧光蛋白的自旋量子比特。金刚石制备技术的进步已实现了光子腔、纳米机械谐振器和微结构器件，这些器件增强了自旋-光子相互作用和室温灵敏度。对替代材料中自旋缺陷的探索进一步拓展了传感领域。在生物相容性方面的平行进展包括用于体外和体内研究的基于芯片的架构、微流控集成，以及能够进行细胞内纳米测温与纳米流变测量的微创纳米金刚石探针。表面功能化的改进提升了复杂环境中的相干性和传感可靠性。总体而言，这些进展凸显了面向生命科学的应用型量子传感所取得的进展及尚存的挑战。
英文摘要
Quantum optical sensing has evolved from isolated solid state spin defect platforms to increasingly bio-integrated systems designed for biomedical applications. This review presents a perspective on this transition, spanning nitrogen vacancy centers in diamond to emerging fluorescent protein based spin qubits. Advances in diamond fabrication have enabled photonic cavities, nanomechanical resonators, and microstructured devices that enhance spin photon interactions and room temperature sensitivity. Exploration of spin defects in alternative materials further expands the sensing landscape. Parallel progress toward biological compatibility includes chip based architectures for in vitro and in vivo studies, microfluidic integration, and minimally invasive nanodiamond probes capable of intracellular nanothermometry and nanorheometry. Improvements in surface functionalization have enhanced coherence and sensing reliability in complex environments. Collectively, these advances highlight the progress and remaining challenges toward application oriented quantum sensing for the life sciences.
