网格状微流控器件堵塞的多尺度模型
Multiscale Model of Clogging in Microfluidic Devices with Grid-Like Geometries
摘要：
我们提出了一个粗粒度的理论模型来捕捉不同条件下，包括恒定的施加流量和恒定的施加压力梯度的微流控器件的老化。通过细胞的变形性对细胞进行分类的微流体装置在医学应用中具有重要的前景。然而，这些微流体系统中的堵塞导致它们的性质随时间变化，并潜在地限制了它们的可靠性。我们比较粗粒度模型的随机模拟和现有的理论研究的结果。最后，我们将该模型应用于实验数据的镰状红细胞堵塞，并讨论其更广泛的适用性。
英文摘要：
We propose a coarse-grained theoretical model to capture the aging of microfluidic devices under different conditions including constant applied flow rate and constant applied pressure gradient. Microfluidic devices that sort cells by their deformability hold significant promise for medical applications. However, clogging in these microfluidic systems causes their properties to change over time and potentially limits their reliability. We compare the results of the coarse-grained model to those of stochastic simulations and to existing theoretical studies. Lastly, we apply the model to experimental data on the clogging of sickle red blood cells and discuss its wider applicability.
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