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arXiv 2107.08158physics.opticseess.IVphysics.bio-ph
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使用波动随机照明通过散射层的大视场非侵入成像

Large field-of-view non-invasive imaging through scattering layers using fluctuating random illumination

Lei Zhu, Fernando Soldevila, Claudio Moretti, Alexandra d'Arco, Antoine Boniface, Xiaopeng Shao, Hilton B. de Aguiar, Sylvain Gigan

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8 pages, 11 figures
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摘要：

无创光学成像技术在许多领域是必不可少的诊断工具。尽管已经提出了各种最近的方法来利用和控制多个散射介质中的光，但是由于光学记忆效应所设定的物理限制，特别是在没有波前成形技术的情况下，穿过大视场的散射层和散射层内部的非侵入式光学成像仍然是难以实现的。在这里，我们展示了一种方法，使非侵入性的荧光成像散射层后面的视野延伸远远超出了光学记忆效应。该方法包括在分层的散斑图案由荧光物体发出的变量未知的随机照明下，使用矩阵分解和一种新的基于指纹的重建。实验验证表明，该方法的效率和鲁棒性与各种荧光样品，覆盖的视野高达三倍的光学记忆效应范围。我们的非侵入性成像技术是简单的，既不需要空间光调制器，也不需要引导星，并且可以推广到广泛的非相干对比机制和照明方案。

英文摘要：

On-invasive optical imaging techniques are essential diagnostic tools in many fields. Although various recent methods have been proposed to utilize and control light in multiple scattering media, non-invasive optical imaging through and inside scattering layers across a large field of view remains elusive due to the physical limits set by the optical memory effect, especially without wavefront shaping techniques. Here, we demonstrate an approach that enables non-invasive fluorescence imaging behind scattering layers with field-of-views extending well beyond the optical memory effect. The method consists in demixing the speckle patterns emitted by a fluorescent object under variable unknown random illumination, using matrix factorization and a novel fingerprint-based reconstruction. Experimental validation shows the efficiency and robustness of the method with various fluorescent samples, covering a field of view up to three times the optical memory effect range. Our non-invasive imaging technique is simple, neither requires a spatial light modulator nor a guide star, and can be generalized to a wide range of incoherent contrast mechanisms and illumination schemes.

机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。

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