Blockwise missing data occurs frequently when we integrate multisource or multimodality data where different sources or modalities contain complementary information. In this paper, we consider a high-dimensional linear regression model with blockwise missing covariates and a partially observed response variable. Under this framework, we propose a computationally efficient estimator for the regression coefficient vector based on carefully constructed unbiased estimating equations and a blockwise imputation procedure, and obtain its rate of convergence. Furthermore, building upon an innovative projected estimating equation technique that intrinsically achieves bias-correction of the initial estimator, we propose a nearly unbiased estimator for each individual regression coefficient, which is asymptotically normally distributed under mild conditions. Based on these debiased estimators, asymptotically valid confidence intervals and statistical tests about each regression coefficient are constructed. Numerical studies and application analysis of the Alzheimer's Disease Neuroimaging Initiative data show that the proposed method performs better and benefits more from unsupervised samples than existing methods.
Missing data are present in most real world problems and need careful handling to preserve the prediction accuracy and statistical consistency in the downstream analysis. As the gold standard of handling missing data, multiple imputation (MI) methods are proposed to account for the imputation uncertainty and provide proper statistical inference. In this work, we propose Multiple Imputation via Generative Adversarial Network (MI-GAN), a deep learning-based (in specific, a GAN-based) multiple imputation method, that can work under missing at random (MAR) mechanism with theoretical support. MI-GA…
We consider high-dimensional multivariate linear regression models, where the joint distribution of covariates and response variables is a multivariate normal distribution with a bandable covariance matrix. The main goal of this paper is to estimate the regression coefficient matrix, which is a function of the bandable covariance matrix. Although the tapering estimator of covariance has the minimax optimal convergence rate for the class of bandable covariances, we show that it has a sub-optimal convergence rate for the regression coefficient; that is, a minimax estimator for the class of banda…
Doubly robust target inference for generalized linear regression with completely missing covariates
School of Mathematics and Statistics, Huazhong University of Science and Technology（华中科技大学数学与统计学院）；Department of Statistics and Data Science, Tsinghua University（清华大学统计与数据科学系）
kNN estimation in semi-functional partial linear regression with missing responses at random
Universidade da Coruña（拉科鲁尼亚大学）；Centro de Investigación en Tecnologías de la Información y las Comunicaciones (CITIC)（信息与通信技术研究中心）；Universidad Carlos III de Madrid（马德里卡洛斯三世大学）
In this paper, we are interested in nonparametric kernel estimation of a generalized regression function, including conditional cumulative distribution and conditional quantile functions, based on an incomplete sample $(X_t, Y_t, ζ_t)_{t\in \mathbb{ R}^+}$ copies of a continuous-time stationary ergodic process $(X, Y, ζ)$. The predictor $X$ is valued in some infinite-dimensional space, whereas the real-valued process $Y$ is observed when $ζ= 1$ and missing whenever $ζ= 0$. Pointwise and uniform consistency (with rates) of these estimators as well as a central limit theorem are established. Con…
We study high-dimensional regression with missing entries in the covariates. A common strategy in practice is to \emph{impute} the missing entries with an appropriate substitute and then implement a standard statistical procedure acting as if the covariates were fully observed. Recent literature on this subject proposes instead to design a specific, often complicated or non-convex, algorithm tailored to the case of missing covariates. We investigate a simpler approach where we fill-in the missing entries with their conditional mean given the observed covariates. We show that this imputation sc…
In this paper, we propose an empirical likelihood-based weighted estimator of regression parameter in quantile regression model with nonignorable missing covariates. The proposed estimator is computationally simple and achieves semiparametric efficiency if the probability of missingness on the fully observed variables is correctly specified. The efficiency gain of the proposed estimator over the complete-case-analysis estimator is quantified theoretically and illustrated via simulation and a real data application.
Wisconsin Institutes for Discovery（威斯康星发现研究院）；University of Wisconsin-Madison（威斯康星大学麦迪逊分校）
This paper proposes a fast and accurate method for sparse regression in the presence of missing data. The underlying statistical model encapsulates the low-dimensional structure of the incomplete data matrix and the sparsity of the regression coefficients, and the proposed algorithm jointly learns the low-dimensional structure of the data and a linear regressor with sparse coefficients. The proposed stochastic optimization method, Sparse Linear Regression with Missing Data (SLRM), performs an alternating minimization procedure and scales well with the problem size. Large deviation inequalities…
For nonparametric regression with one-sided errors and a boundary curve model for Poisson point processes we consider the problem of efficient estimation for linear functionals. The minimax optimal rate is obtained by an unbiased estimation method which nevertheless depends on a Hölder condition or monotonicity assumption for the underlying regression or boundary function. We first construct a simple blockwise estimator and then build up a nonparametric maximum-likelihood approach for exponential noise variables and the point process model. In that approach also non-asymptotic efficiency is ob…
In this paper, we consider a weighted local linear estimator based on the inverse selection probability for nonparametric regression with missing covariates at random. The asymptotic distribution of the maximal deviation between the estimator and the true regression function is derived and an asymptotically accurate simultaneous confidence band is constructed. The estimator for the regression function is shown to be oracally efficient in the sense that it is uniformly indistinguishable from that when the selection probabilities are known. Finite sample performance is examined via simulation st…
Estimation of the density of regression errors is a fundamental issue in regression analysis and it is typically explored via a parametric approach. This article uses a nonparametric approach with the mean integrated squared error (MISE) criterion. It solves a long-standing problem, formulated two decades ago by Mark Pinsker, about estimation of a nonparametric error density in a nonparametric regression setting with the accuracy of an oracle that knows the underlying regression errors. The solution implies that, under a mild assumption on the differentiability of the design density and regres…
The standard quantile regression model assumes a linear relationship at the quantile of interest and that all variables are observed. We relax these assumptions by considering a partial linear model while allowing for missing linear covariates. To handle the potential bias caused by missing data we propose a weighted objective function using inverse probability weighting. Our work examines estimators using parametric and nonparametric estimates of the missing probability. For variable selection of the linear terms in the presence of missing data we consider a penalized and weighted objective f…
Georgia State University（佐治亚州立大学）；University of Waterloo（滑铁卢大学）
We present a robust framework to perform linear regression with missing entries in the features. By considering an elliptical data distribution, and specifically a multivariate normal model, we are able to conditionally formulate a distribution for the missing entries and present a robust framework, which minimizes the worst case error caused by the uncertainty about the missing data. We show that the proposed formulation, which naturally takes into account the dependency between different variables, ultimately reduces to a convex program, for which a customized and scalable solver can be deli…
This article considers nonparametric regression models with multivariate covariates and with responses missing at random. We estimate the regression function with a local polynomial smoother. The residual-based empirical distribution function that only uses complete cases, i.e. residuals that can actually be constructed from the data, is shown to be efficient in the sense of Hájek and Le Cam. In the proofs we derive, more generally, the efficient influence function for estimating an arbitrary linear functional of the error distribution; this covers the distribution function as a special case. …
Carnegie Mellon University（卡内基梅隆大学）；University of Chicago（芝加哥大学）
Although a majority of the theoretical literature in high-dimensional statistics has focused on settings which involve fully-observed data, settings with missing values and corruptions are common in practice. We consider the problems of estimation and of constructing component-wise confidence intervals in a sparse high-dimensional linear regression model when some covariates of the design matrix are missing completely at random. We analyze a variant of the Dantzig selector [9] for estimating the regression model and we use a de-biasing argument to construct component-wise confidence intervals.…
Logistic regression is a common classification method in supervised learning. Surprisingly, there are very few solutions for performing logistic regression with missing values in the covariates. We suggest a complete approach based on a stochastic approximation version of the EM algorithm to do statistical inference with missing values including the estimation of the parameters and their variance, derivation of confidence intervals and a model selection procedure. We also tackle the problem of prediction for new observations (on a test set) with missing covariate data. The methodology is compu…
In a missing-data setting, we have a sample in which a vector of explanatory variables x_i is observed for every subject i, while scalar outcomes y_i are missing by happenstance on some individuals. In this work we propose robust estimates of the distribution of the responses assuming missing at random (MAR) data, under a semiparametric regression model. Our approach allows the consistent estimation of any weakly continuous functional of the response's distribution. In particular, strongly consistent estimates of any continuous location functional, such as the median or MM functionals, are pro…
In this article, we consider an imputation method to handle missing response values based on semiparametric quantile regression estimation. In the proposed method, the missing response values are generated using the estimated conditional quantile regression function at given values of covariates. We adopt the generalized method of moments for estimation of parameters defined through a general estimation equation. We demonstrate that the proposed estimator, which combines both semiparametric quantile regression imputation and generalized method of moments, has competitive edge against some of t…
Data loss is a critical problem in structural health monitoring (SHM). Probability distributions play a highly important role in many applications. Improving the quality of distribution estimations made using incomplete samples is highly important. Missing samples can be compensated for by applying conventional missing data restoration methods; however, ensuring that restored samples roughly follow underlying distributions of true missing data remains a challenge. Another strategy involves directly restoring the probability density function (PDF) for a sensor when samples are missing by levera…
Missing covariates in regression or classification problems can prohibit the direct use of advanced tools for further analysis. Recent research has realized an increasing trend towards the usage of modern Machine Learning algorithms for imputation. It originates from their capability of showing favourable prediction accuracy in different learning problems. In this work, we analyze through simulation the interaction between imputation accuracy and prediction accuracy in regression learning problems with missing covariates when Machine Learning based methods for both, imputation and prediction a…
Linear quantile regression models aim at providing a detailed and robust picture of the (conditional) response distribution as function of a set of observed covariates. Longitudinal data represent an interesting field of application of such models; due to their peculiar features, they represent a substantial challenge, in that the standard, cross-sectional, model representation needs to be extended for dealing with such kind of data. In fact, repeated observations from the same statistical unit poses a problem of dependence; in a conditional perspective, this dependence could be ascribed to so…
Imputation is a popular technique for handling missing data. We consider a nonparametric approach to imputation using the kernel ridge regression technique and propose consistent variance estimation. The proposed variance estimator is based on a linearization approach which employs the entropy method to estimate the density ratio. The root-n consistency of the imputation estimator is established when a Sobolev space is utilized in the kernel ridge regression imputation, which enables us to develop the proposed variance estimator. Synthetic data experiments are presented to confirm our theory.
Multiple matrix sampling is a survey methodology technique that randomly chooses a relatively small subset of items to be presented to survey respondents for the purpose of reducing respondent burden. The data produced are missing completely at random (MCAR), and special missing data techniques should be used in linear regression and other multivariate statistical analysis. We derive asymptotic variances of regression parameter estimates that allow us to conduct power analysis for linear regression models fit to the data obtained via a multiple matrix sampling design. The ideas are demonstrate…
Longitudinal data are characterized by the dependence between observations coming from the same individual. In a regression perspective, such a dependence can be usefully ascribed to unobserved features (covariates) specific to each individual. On these grounds, random parameter models with time-constant or time-varying structure are well established in the generalized linear model context. In the quantile regression framework, specifications based on random parameters have only recently known a flowering interest. We start from the recent proposal by Farcomeni (2012) on longitudinal quantile …
This paper considers an empirical likelihood inference for parameters defined by general estimating equations, when data are missing at random. The efficiency of existing estimators depends critically on correctly specifying the conditional expectation of the estimating function given the observed components of the random observations. When the conditional expectation is not correctly specified, the efficiency of estimation can be severely compromised even if the propensity function (of missingness) is correctly specified. We propose an efficient estimator which enjoys the double-robustness pr…
We study problems with multiple missing covariates and partially observed responses. We develop a new framework to handle complex missing covariate scenarios via inverse probability weighting, regression adjustment, and a multiply-robust procedure. We apply our framework to three classical problems: the Cox model from survival analysis, missing response, and binary treatment from causal inference. We also discuss how to handle missing covariates in these scenarios, and develop associated identifying theories and asymptotic theories. We apply our procedure to simulations and an Alzheimer's dise…
The proposed smooth blockwise iterative thresholding estimator (SBITE) is a model selection technique defined as a fixed point reached by iterating a likelihood gradient-based thresholding function. The smooth James-Stein thresholding function has two regularization parameters $λ$ and $ν$, and a smoothness parameter $s$. It enjoys smoothness like ridge regression and selects variables like lasso. Focusing on Gaussian regression, we show that SBITE is uniquely defined, and that its Stein unbiased risk estimate is a smooth function of $λ$ and $ν$, for better selection of the two regularization p…
We consider the estimation problem in a regression setting where the outcome variable is subject to nonignorable missingness and identifiability is ensured by the shadow variable approach. We propose a versatile estimation procedure where modeling of missingness mechanism is completely bypassed. We show that our estimator is easy to implement and we derive the asymptotic theory of the proposed estimator. We also investigate some alternative estimators under different scenarios. Comprehensive simulation studies are conducted to demonstrate the finite sample performance of the method. We apply t…
Electricité De France R&D（法国电力公司研发部）；INRIA（法国国家信息与自动化研究所）；CNRS（法国国家科学研究中心）；École polytechnique（巴黎综合理工学院）；Institut Polytechnique de Paris（巴黎理工学院）；Technion - Israel Institute of Technology（以色列理工学院）
Augmented transfer regression learning for completely missing covariates
School of Mathematics and Statistics, Huazhong University of Science and Technology（华中科技大学数学与统计学院）；Department of Statistics, Colorado State University（科罗拉多州立大学统计学系）
A residual-based empirical distribution function is proposed to estimate the distribution function of the errors of a heteroskedastic nonparametric regression with responses missing at random based on completely observed data, and this estimator is shown to be asymptotically most precise.
We investigate methods for penalized regression in the presence of missing observations. This paper introduces a method for estimating the parameters which compensates for the missing observations. We first, derive an unbiased estimator of the objective function with respect to the missing data and then, modify the criterion to ensure convexity. Finally, we extend our approach to a family of models that embraces the mean imputation method. These approaches are compared to the mean imputation method, one of the simplest methods for dealing with missing observations problem, via simulations. We …
We consider the situation of estimating Cox regression in which some covariates are subject to missing, and there exists additional information (including observed event time, censoring indicator and fully observed covariates) which may be predictive of the missing covariates. We propose to use two working regression models: one for predicting the missing covariates and the other for predicting the missing probabilities. For each missing covariate observation, these two working models are used to define a nearest neighbor imputing set. This set is then used to nonparametrically impute covariat…
