用显微拉曼光谱读出辐射变色薄膜的高空间分辨率剂量测量及其不确定度分析
High spatial resolution dosimetry with uncertainty analysis using Raman micro-spectroscopy readout of radiochromic films
摘要：
目的：本工作的目的是发展一种基于拉曼显微光谱扫描辐射变色薄膜（RCF）的高空间分辨率剂量学新方法。我们在0-50 Gy的扩展剂量范围内生成剂量校准曲线，并提高了对低剂量（<2 Gy）的灵敏度，此外还评估了不确定性。方法：采用0.03 ~ 50 Gy宽剂量范围照射RCF（EBT 3）。拉曼光谱是用定制的拉曼显微光谱装置获得的，该装置包括500 mW、多模785 nm激光器。34 μ m的焦深使得能够同时从RCF活性层和聚酯层压板收集拉曼光谱。将预处理的拉曼光谱归一化为来自未被辐射改变的聚酯层压材料的1614 cm-1拉曼峰的强度。在整个剂量范围内确定了拉曼显微光谱和RCF剂量测量系统的实验、拟合和总剂量不确定度。结果：在本研究中，获得了RCF剂量响应的高分辨率，甚至低至0.03 Gy。基于RCF中的所有三个拉曼峰的校准曲线的动态范围扩展到50 Gy，没有饱和。在30 × 30 μ m^2的空间分辨率下，对于所有三条拉曼校准曲线，在0.5 Gy至50 Gy剂量范围内估算剂量的总不确定度为[6 - 9]%。这包括[5 - 8]%的实验不确定度和[2.5 - 4.5]%的拟合不确定度。结论：高空间分辨率的实验剂量测定技术的基础上拉曼显微光谱和RCF这里提出的，可以成为有用的应用程序，以及应用程序的基础上小场剂量测定。
英文摘要：
Purpose: The purpose of this work is to develop a new approach for high spatial resolution dosimetry based on Raman micro-spectroscopy scanning of radiochromic film (RCF). We generate dose calibration curves over an extended dose range from 0-50 Gy and with improved sensitivity to low (<2 Gy) doses, in addition to evaluating uncertainties. Methods: Samples of RCF (EBT3) were irradiated at a broad dose-range of 0.03 Gy-50 Gy. Raman spectra were acquired with a custom-built Raman micro-spectroscopy setup involving a 500 mW, multimode 785 nm laser. The depth of focus of 34 um enabled the concurrent collection of Raman spectra from the RCF active layer and the polyester laminate. The pre-processed Raman spectra were normalized to the intensity of the 1614 cm-1 Raman peak from the polyester laminate that was unaltered by radiation. The experimental, fitting and total dose uncertainty was determined across the entire dose range for the dosimetry system of Raman micro-spectroscopy and RCF. Results: High resolution in the dose response of the RCF, even down to 0.03 Gy, was obtained in this study. The dynamic range of the calibration curves based on all three Raman peaks in the RCF extended up to 50 Gy with no saturation. At a spatial resolution of 30X30 um^2, the total uncertainty in estimating dose in the 0.5 Gy to 50 Gy dose range was [6 - 9]% for all three Raman calibration curves. This consisted of the experimental uncertainty of [5 - 8]%, and the fitting uncertainty of [2.5 - 4.5]%. Conclusions: The high spatial resolution experimental dosimetry technique based on Raman micro-spectroscopy and RCF presented here, could become useful for applications in, as well as for applications based on small field dosimetry.
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