A significant research problem of recent interest is the localization of targets like vessels, surgical needles, and tumors in photoacoustic (PA) images. To achieve accurate localization, a high photoacoustic signal-to-noise ratio (SNR) is required. However, this is not guaranteed for deep targets, as optical scattering causes an exponential decay in optical fluence with respect to tissue depth. To address this, we develop a novel deep learning method designed to explicitly exhibit robustness to noise present in photoacoustic radio-frequency (RF) data. More precisely, we describe and evaluate a deep neural network architecture consisting of a shared encoder and two parallel decoders. One decoder extracts the target coordinates from the input RF data while the other boosts the SNR and estimates clean RF data. The joint optimization of the shared encoder and dual decoders lends significant noise robustness to the features extracted by the encoder, which in turn enables the network to contain detailed information about deep targets that may be obscured by noise. Additional custom layers and newly proposed regularizers in the training loss function (designed based on observed RF data signal and noise behavior) serve to increase the SNR in the cleaned RF output and improve model performance. To account for depth-dependent strong optical scattering, our network was trained with simulated photoacoustic datasets of targets embedded at different depths inside tissue media of different scattering levels. The network trained on this novel dataset accurately locates targets in experimental PA data that is clinically relevant with respect to the localization of vessels, needles, or brachytherapy seeds. We verify the merits of the proposed architecture by outperforming the state of the art on both simulated and experimental datasets.
Photoacoustic imaging is a new imaging technology in recent years, which combines the advantages of high resolution and rich contrast of optical imaging with the advantages of high penetration depth of acoustic imaging. Photoacoustic imaging has been widely used in biomedical fields, such as brain imaging, tumor detection and so on. The signal-to-noise ratio (SNR) of image signals in photoacoustic imaging is generally low due to the limitation of laser pulse energy, electromagnetic interference in the external environment and system noise. In order to solve the problem of low SNR of photoacous…
A new development in photoacoustic (PA) imaging has been the use of compact, portable and low-cost laser diodes (LDs), but LD-based PA imaging suffers from low signal intensity recorded by the conventional transducers. A common method to improve signal strength is temporal averaging, which reduces frame rate and increases laser exposure to patients. To tackle this problem, we propose a deep learning method that will denoise the PA images before beamforming with a very few frames, even one. We also present a deep learning method to automatically reconstruct point sources from noisy pre-beamform…
The quality of the reconstructed photoacoustic image largely depends on the amount of photoacoustic (PA) boundary data available, which in turn is proportional to the number of detectors employed. In case of limited data (owing to less number of detectors due to cost/instrumentation constraints), the reconstructed PA images suffer from artifacts and are often noisy. In this work, for the first time, a deep learning based model was developed to super resolve and denoise the photoacoustic sinogram data. The proposed method was compared with existing nearest neighbor interpolation and wavelet bas…
Photoacoustic (PA) imaging is an emerging hybrid imaging modality that combines rich optical spectroscopic contrast and high ultrasonic resolution and thus holds tremendous promise for a wide range of pre-clinical and clinical applications. Compact and affordable light sources such as light-emitting diodes (LEDs) and laser diodes (LDs) are promising alternatives to bulky and expensive solid-state laser systems that are commonly used as PA light sources. These could accelerate the clinical translation of PA technology. However, PA signals generated with these light sources are readily degraded …
Rensselaer Polytechnic Institute（伦斯勒理工学院）；Michigan State University（密歇根州立大学）
Photoacoustic tomography seeks to reconstruct an acoustic initial pressure distribution from the measurement of the ultrasound waveforms. Conventional methods assume a-prior knowledge of the sound speed distribution, which practically is unknown. One way to circumvent the issue is to simultaneously reconstruct both the acoustic initial pressure and speed. In this article, we develop a novel data-driven method that integrates an advanced deep neural network through model-based iteration. The image of the initial pressure is significantly improved in our numerical simulation.
University of California, San Diego（加利福尼亚大学圣迭戈分校）；Qualcomm Institute, University of California, San Diego（加利福尼亚大学圣迭戈分校高通研究所）
Low fluence illumination sources can facilitate clinical transition of photoacoustic imaging because they are rugged, portable, affordable, and safe. However, these sources also decrease image quality due to their low fluence. Here, we propose a denoising method using a multi-level wavelet-convolutional neural network to map low fluence illumination source images to its corresponding high fluence excitation map. Quantitative and qualitative results show a significant potential to remove the background noise and preserve the structures of target. Substantial improvements up to 2.20, 2.25, and 4…
Estimation of blood oxygenation with spectroscopic photoacoustic imaging is a promising tool for several biomedical applications. For this method to be quantitative, it relies on an accurate method of the light fluence in the tissue. This is difficult deep in heterogeneous tissue, where different wavelengths of light can experience significantly different attenuation. In this work, we developed a new deep neural network to simultaneously estimate the oxygen saturation in blood vessels and segment the vessels from the surrounding background tissue. The network was trained on estimated initial p…
The paper proposes a new high spatial resolution hyperspectral (HR-HS) image estimation method based on convex optimization. The method assumes a low spatial resolution HS (LR-HS) image and a guide image as observations, where both observations are contaminated by noise. Our method simultaneously estimates an HR-HS image and a noiseless guide image, so the method can utilize spatial information in a guide image even if it is contaminated by heavy noise. The proposed estimation problem adopts hybrid spatio-spectral total variation as regularization and evaluates the edge similarity between HR-H…
Gating is commonly used in PET imaging to reduce respiratory motion blurring and facilitate more sophisticated motion correction methods. In the applications of low dose PET, however, reducing injection dose causes increased noise and reduces signal-to-noise ratio (SNR), subsequently corrupting the motion estimation/correction steps, causing inferior image quality. To tackle these issues, we first propose a Siamese adversarial network (SAN) that can efficiently recover high dose gated image volume from low dose gated image volume. To ensure the appearance consistency between the recovered gate…
Denoising method for dynamic contrast-enhanced CT perfusion studies using three-dimensional deep image prior as a simultaneous spatial and temporal regularizer
Simultaneous Motion And Noise Estimation with Event Cameras
Keio University（庆应大学）；Woven by Toyota, Inc.（丰田公司）；Technische Universität Berlin（柏林技术大学）；Einstein Center Digital Future, Robotics Institute Germany, and Science of Intelligence Excellence Cluster, Germany（数字未来爱因斯坦中心、德国机器人研究所及智能科学卓越中心）
Xiamen University（厦门大学）；University of Science and Technology of China（中国科学技术大学）；Columbia University（哥伦比亚大学）
We propose a new framework called Noise2Blur (N2B) for training robust image denoising models without pre-collected paired noisy/clean images. The training of the model requires only some (or even one) noisy images, some random unpaired clean images, and noise-free but blurred labels obtained by predefined filtering of the noisy images. The N2B model consists of two parts: a denoising network and a noise extraction network. First, the noise extraction network learns to output a noise map using the noise information from the denoising network under the guidence of the blurred labels. Then, the …
Hyperspectral image (HSI) denoising is of crucial importance for many subsequent applications, such as HSI classification and interpretation. In this paper, we propose an attention-based deep residual network to directly learn a mapping from noisy HSI to the clean one. To jointly utilize the spatial-spectral information, the current band and its $K$ adjacent bands are simultaneously exploited as the input. Then, we adopt convolution layer with different filter sizes to fuse the multi-scale feature, and use shortcut connection to incorporate the multi-level information for better noise removal.…
Worcester Polytechnic Institute（伍斯特理工学院）；Colorado State University（科罗拉多州立大学）
In this paper, we demonstrate how deep autoencoders can be generalized to the case of inpainting and denoising, even when no clean training data is available. In particular, we show how neural networks can be trained to perform all of these tasks simultaneously. While, deep autoencoders implemented by way of neural networks have demonstrated potential for denoising and anomaly detection, standard autoencoders have the drawback that they require access to clean data for training. However, recent work in Robust Deep Autoencoders (RDAEs) shows how autoencoders can be trained to eliminate outliers…
Hybrid Convolutional and Attention Network for Hyperspectral Image Denoising
School of Computer Science and Technology, Ocean University of China（中国海洋大学计算机科学与技术学院）；Department of Electrical and Computer Engineering, Mississippi State University（密西西比州立大学电气与计算机工程系）
Low-light image sequences generally suffer from spatio-temporal incoherent noise, flicker and blurring of moving objects. These artefacts significantly reduce visual quality and, in most cases, post-processing is needed in order to generate acceptable quality. Most state-of-the-art enhancement methods based on machine learning require ground truth data but this is not usually available for naturally captured low light sequences. We tackle these problems with an unpaired-learning method that offers simultaneous colorization and denoising. Our approach is an adaptation of the CycleGAN structure.…
Deep Joint Denoising and Detection for Enhanced Intracellular Particle Analysis
Erasmus University Medical Center（伊拉斯姆斯大学医学中心）；Utrecht University（乌得勒支大学）；University of New South Wales (UNSW)（新南威尔士大学）；NVIDIA Corporation（英伟达公司）；SURFsara
Recently, convolutional neural networks (CNNs) and attention mechanisms have been widely used in image denoising and achieved satisfactory performance. However, the previous works mostly use a single head to receive the noisy image, limiting the richness of extracted features. Therefore, a novel CNN with multiple heads (MH) named MHCNN is proposed in this paper, whose heads will receive the input images rotated by different rotation angles. MH makes MHCNN simultaneously utilize features of rotated images to remove noise. To integrate these features effectively, we present a novel multi-path at…
Hyperspectral image (HSI) denoising aims to restore clean HSI from the noise-contaminated one. Noise contamination can often be caused during data acquisition and conversion. In this paper, we propose a novel spatial-spectral total variation (SSTV) regularized nonconvex local low-rank (LR) tensor approximation method to remove mixed noise in HSIs. From one aspect, the clean HSI data have its underlying local LR tensor property, even though the real HSI data may not be globally low-rank due to out-liers and non-Gaussian noise. According to this fact, we propose a novel tensor $L_γ$-norm to form…
With recent deep learning based approaches showing promising results in removing noise from images, the best denoising performance has been reported in a supervised learning setup that requires a large set of paired noisy images and ground truth for training. The strong data requirement can be mitigated by unsupervised learning techniques, however, accurate modelling of images or noise variance is still crucial for high-quality solutions. The learning problem is ill-posed for unknown noise distributions. This paper investigates the tasks of image denoising and noise variance estimation in a si…
Southwest University（西南大学）；China West Normal University（西华师范大学）
Mining structural priors in data is a widely recognized technique for hyperspectral image (HSI) denoising tasks, whose typical ways include model-based methods and data-based methods. The model-based methods have good generalization ability, while the runtime cannot meet the fast processing requirements of the practical situations due to the large size of an HSI data $ \mathbf{X} \in \mathbb{R}^{MN\times B}$. For the data-based methods, they perform very fast on new test data once they have been trained. However, their generalization ability is always insufficient. In this paper, we propose a …
University of Electronic Science and Technology of China（电子科技大学）；Shanghai Jiao Tong University（上海交通大学）
Hyperspectral image (HSI) has some advantages over natural image for various applications due to the extra spectral information. During the acquisition, it is often contaminated by severe noises including Gaussian noise, impulse noise, deadlines, and stripes. The image quality degeneration would badly effect some applications. In this paper, we present a HSI restoration method named smooth and robust low rank tensor recovery. Specifically, we propose a structural tensor decomposition in accordance with the linear spectral mixture model of HSI. It decomposes a tensor into sums of outer matrix v…
Sichuan University（四川大学）；Institute of High Performance Computing, A*STAR（A*STAR高性能计算研究所）
Multi-scale architectures have shown effectiveness in a variety of tasks thanks to appealing cross-scale complementarity. However, existing architectures treat different scale features equally without considering the scale-specific characteristics, \textit{i.e.}, the within-scale characteristics are ignored in the architecture design. In this paper, we reveal this missing piece for multi-scale architecture design and accordingly propose a novel Multi-Scale Adaptive Network (MSANet) for single image denoising. Specifically, MSANet simultaneously embraces the within-scale characteristics and the…
An important step of seismic data processing is removing noise, including interference due to simultaneous and blended sources, from the recorded data. Traditional methods are time-consuming to apply as they often require manual choosing of parameters to obtain good results. We use deep learning, with a U-net model incorporating a ResNet architecture pretrained on ImageNet and further trained on synthetic seismic data, to perform this task. The method is applied to common offset gathers, with adjacent offset gathers of the gather being denoised provided as additional input channels. Here we sh…
Hyperspectral image denoising is unique for the highly similar and correlated spectral information that should be properly considered. However, existing methods show limitations in exploring the spectral correlations across different bands and feature interactions within each band. Besides, the low- and high-level features usually exhibit different importance for different spatial-spectral regions, which is not fully explored for current algorithms as well. In this paper, we present a Mixed Attention Network (MAN) that simultaneously considers the inter- and intra-spectral correlations as well…
University of Notre Dame（圣母大学）；California Institute of Technology（加州理工学院）；Indiana University（印第安纳大学）
Fluorescence lifetime imaging microscopy (FLIM) systems are limited by their slow processing speed, low signal-to-noise ratio (SNR), and expensive and challenging hardware setups. In this work, we demonstrate applying a denoising convolutional network to improve FLIM SNR. The network will be integrated with an instant FLIM system with fast data acquisition based on analog signal processing, high SNR using high-efficiency pulse-modulation, and cost-effective implementation utilizing off-the-shelf radio-frequency components. Our instant FLIM system simultaneously provides the intensity, lifetime…
